INT73490

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Context Info
Confidence 0.42
First Reported 1997
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 0.36
Pain Relevance 1.80

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
hypothalamus 1
respiratory 1
INTU (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 4 95.36 Very High Very High Very High
mu opioid receptor 2 94.88 High High
Kappa opioid receptor 2 88.72 High High
agonist 6 86.84 High High
Delta opioid receptors 2 81.68 Quite High
medulla 10 80.20 Quite High
anesthesia 2 79.52 Quite High
Opioid 8 75.00 Quite High
Pain 6 71.08 Quite High
Spinal cord 4 69.20 Quite High
Disease Link Frequency Relevance Heat
Body Weight 2 89.76 High High
Nociception 3 75.32 Quite High
Pain 4 66.48 Quite High
Respiratory Failure 2 55.24 Quite High
Subarachnoid Hemorrhage 63 50.00 Quite Low
Stress 18 50.00 Quite Low
INFLAMMATION 17 49.16 Quite Low
Disease 3 17.76 Low Low
Increased Venous Pressure Under Development 23 5.00 Very Low Very Low Very Low
Demyelinating Disease 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
During Trial 1, licking duration was longer in the INT-FF group than in GDX-FF; during Trial 2, there was no difference between the two groups due to the decrease in INT-FF alone. c-Fos expression, determined in the arcuate nucleus of the hypothalamus in the same animals 1 week after the last formalin test, was higher in GDX than INT animals; moreover, while in INT rats, c-Fos was higher in the formalin-injected animals (SF and FF) than in HC, in GDX, it did not differ among groups.
Negative_regulation (decrease) of INT in hypothalamus
1) Confidence 0.42 Published 2006 Journal Brain Res. Section Abstract Doc Link 16854390 Disease Relevance 0.22 Pain Relevance 0.20
The CBF and int-PmO2 was reduced following the injection of each of the three doses of Pri-Fely.
Negative_regulation (reduced) of int
2) Confidence 0.18 Published 2003 Journal Eur. J. Oral Sci. Section Abstract Doc Link 12887400 Disease Relevance 0.09 Pain Relevance 0.08
By consuming financial resources health technologies will impede public health promotion and preventive activities" (Int #13).
Negative_regulation (impede) of Int
3) Confidence 0.18 Published 2010 Journal Health Res Policy Syst Section Body Doc Link PMC2907640 Disease Relevance 0 Pain Relevance 0
DAGO reduced fR and Ti in a concentration-dependent manner and caused a reduction of Int(C4) at high concentrations (10 microM).
Negative_regulation (reduction) of Int
4) Confidence 0.13 Published 1997 Journal Brain Res. Section Abstract Doc Link 9462896 Disease Relevance 0.06 Pain Relevance 0.85
DPDPE had no effect on respiratory activities whereas U50,488, like DAGO, reduced fR and Int(C4) in a concentration-dependent manner.
Neg (no) Negative_regulation (reduced) of Int in respiratory
5) Confidence 0.11 Published 1997 Journal Brain Res. Section Abstract Doc Link 9462896 Disease Relevance 0 Pain Relevance 0.68
One unit of SOD is that which causes a 50% inhibition of the rate of reduction of INT under the conditions of the assay.
Negative_regulation (reduction) of INT
6) Confidence 0.02 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2821769 Disease Relevance 0 Pain Relevance 0

General Comments

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