INT73553

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Context Info
Confidence 0.67
First Reported 1998
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 23
Total Number 23
Disease Relevance 4.65
Pain Relevance 1.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transmembrane transporter activity (Aqp1) plasma membrane (Aqp1) nucleus (Aqp1)
cytoplasm (Aqp1)
Anatomy Link Frequency
taste receptor cells 3
epithelial cells 2
renal tubules 1
choroid plexus 1
oocytes 1
Aqp1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
hyperexcitability 4 97.32 Very High Very High Very High
addiction 20 97.00 Very High Very High Very High
Central nervous system 119 94.48 High High
sodium channel 17 89.24 High High
cINOD 2 84.72 Quite High
agonist 86 83.84 Quite High
ischemia 50 78.80 Quite High
Calcium channel 7 76.80 Quite High
Neurotransmitter 15 74.16 Quite High
fibrosis 34 69.24 Quite High
Disease Link Frequency Relevance Heat
Aging 4 100.00 Very High Very High Very High
Apoptosis 1018 99.12 Very High Very High Very High
Stress 91 98.88 Very High Very High Very High
Ganglion Cysts 33 98.52 Very High Very High Very High
Infection 4 96.64 Very High Very High Very High
Toxicity 14 92.04 High High
Neurodegenerative Disease 94 85.28 High High
INFLAMMATION 65 84.32 Quite High
Necrosis 60 81.56 Quite High
Cv Unclassified Under Development 36 78.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The virus used directed the synthesis of human aquaporin-1, a water channel protein, and is termed AdhAQP1.
Gene_expression (synthesis) of aquaporin-1
1) Confidence 0.67 Published 1998 Journal J. Oral Pathol. Med. Section Abstract Doc Link 9466733 Disease Relevance 0.22 Pain Relevance 0.11
The virus used directed the synthesis of human aquaporin-1, a water channel protein, and is termed AdhAQP1.
Gene_expression (synthesis) of AdhAQP1
2) Confidence 0.66 Published 1998 Journal J. Oral Pathol. Med. Section Abstract Doc Link 9466733 Disease Relevance 0.24 Pain Relevance 0.11
While AQP1 is expressed by cornea endothelium, ciliary and lens epithelia, trabecular meshwork [15], pigment epithelial cells [16], rodent amacrine cells [17,18], and photoreceptor cells [19], AQP3 is detected in conjunctiva [20].
Gene_expression (expressed) of AQP1 in epithelial cells
3) Confidence 0.63 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2831780 Disease Relevance 0.46 Pain Relevance 0.03
Although AQP1 and 9 are common to both the efferent ductules and epididymis, regulation of their expression shows significant divergence, as AQP1 appears to be constitutively expressed, while AQP9 responds to both estrogen and androgen [16].
Gene_expression (expressed) of AQP1 in ductules
4) Confidence 0.58 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1615873 Disease Relevance 0 Pain Relevance 0
Several types of aquaporins are expressed by taste receptor cells including AQP5, which is expressed on the apical membrane, and AQP1 and AQP2 which are expressed on the basolateral membrane (Gilbertson et al., 2006).
Gene_expression (expressed) of AQP1 in taste receptor cells
5) Confidence 0.52 Published 2010 Journal Frontiers in Neuroscience Section Body Doc Link PMC2967336 Disease Relevance 0 Pain Relevance 0.11
As shown in Figure 7, renal tubules of TT/IR group displaying cystic dilatations exhibited immunostaining for AQP1 (panel A) but not AQP2 (panel B).
Gene_expression (immunostaining) of AQP1 in renal tubules
6) Confidence 0.49 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2994366 Disease Relevance 0.48 Pain Relevance 0.04
Several types of aquaporins are expressed by taste receptor cells including AQP5, which is expressed on the apical membrane, and AQP1 and AQP2 which are expressed on the basolateral membrane (Gilbertson et al., 2006).
Gene_expression (expressed) of AQP1 in taste receptor cells
7) Confidence 0.45 Published 2010 Journal Frontiers in Neuroscience Section Body Doc Link PMC2967336 Disease Relevance 0 Pain Relevance 0.11
Several types of aquaporins are expressed by taste receptor cells including AQP5, which is expressed on the apical membrane, and AQP1 and AQP2 which are expressed on the basolateral membrane (Gilbertson et al., 2006).
Gene_expression (expressed) of AQP1 in taste receptor cells
8) Confidence 0.45 Published 2010 Journal Frontiers in Neuroscience Section Body Doc Link PMC2967336 Disease Relevance 0 Pain Relevance 0.11
Reduced expression of AQP1 and its recovery after space flight was reported, suggesting the regulation of the AQP1 expression by gravity [80].
Gene_expression (expression) of AQP1
9) Confidence 0.41 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2647147 Disease Relevance 0 Pain Relevance 0.07
Expression of AQP1 is restricted to the apical microvilli of the villous like processes of the epithelial cells of the rat choroids plexus [40].
Gene_expression (Expression) of AQP1 in epithelial cells
10) Confidence 0.41 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2647147 Disease Relevance 0 Pain Relevance 0.09
Although whether the increased AQP1 expression observed during hypertonic stress is an effect of direct water loss or a compensatory mechanism is not clear, the importance of AQP in cellular volume exchange is evident.
Gene_expression (expression) of AQP1 associated with stress
11) Confidence 0.41 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2647147 Disease Relevance 0.47 Pain Relevance 0
Employing real-time PCR technique, our data demonstrated that cortical neurons induced to undergo apoptosis via lactacystin treatment showed increased AQP1 expression at 6 h (Fig. 1).
Gene_expression (expression) of AQP1 in neurons associated with apoptosis
12) Confidence 0.41 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2647147 Disease Relevance 0.65 Pain Relevance 0
Reduced expression of AQP1 and its recovery after space flight was reported, suggesting the regulation of the AQP1 expression by gravity [80].
Gene_expression (expression) of AQP1
13) Confidence 0.41 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2647147 Disease Relevance 0 Pain Relevance 0.07
In fact the group showed that the reduction in ubiquitination occurred in parallel with an increase in total AQP1 protein expression.
Gene_expression (expression) of AQP1
14) Confidence 0.41 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2647147 Disease Relevance 0.60 Pain Relevance 0
In addition, the expression of several aquaporins including AQP1, AQP2, AQP3, and AQP5 decrease with aging [49–51], and therefore AQP4 expression may also decrease with aging.
Gene_expression (expression) of AQP1 associated with aging
15) Confidence 0.39 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2559817 Disease Relevance 0.20 Pain Relevance 0.05
In addition, the expression of several aquaporins including AQP1, AQP2, AQP3, and AQP5 decrease with aging [49–51], and therefore AQP4 expression may also decrease with aging.
Gene_expression (expression) of AQP1 associated with aging
16) Confidence 0.39 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2559817 Disease Relevance 0.19 Pain Relevance 0.05
AQP1 is expressed in microvascular endothelium, while AQP3 and AQP4 are expressed in large airways.
Gene_expression (expressed) of AQP1 in endothelium
17) Confidence 0.37 Published 2004 Journal Crit Care Section Body Doc Link PMC522843 Disease Relevance 0.52 Pain Relevance 0.27
These studies were then extended to AQP1 expressed in rat choroid plexus epithelial cells [104].
Gene_expression (expressed) of AQP1 in choroid plexus epithelial cells
18) Confidence 0.29 Published 2007 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC2072944 Disease Relevance 0 Pain Relevance 0.03
AQP1 was already known to be expressed at high concentrations in the apical membrane of the mammalian choroid plexus, and is thought to play an important role in water transport by the choroid plexus [105,106].
Gene_expression (expressed) of AQP1 in choroid plexus
19) Confidence 0.29 Published 2007 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC2072944 Disease Relevance 0 Pain Relevance 0
The AQP1 currents were inhibited by 200?
Gene_expression (currents) of AQP1
20) Confidence 0.25 Published 2007 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC2072944 Disease Relevance 0 Pain Relevance 0.05

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