INT73557

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Context Info
Confidence 0.46
First Reported 1996
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 57
Total Number 57
Disease Relevance 8.70
Pain Relevance 3.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (RELA) nucleoplasm (RELA) aging (RELA)
nucleus (RELA) DNA binding (RELA) transcription factor binding (RELA)
Anatomy Link Frequency
mere 4
B-cell 2
macrophages 1
dentate gyrus 1
bone marrow 1
RELA (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 179 99.72 Very High Very High Very High
fluoxetine 8 99.58 Very High Very High Very High
Arthritis 118 99.40 Very High Very High Very High
Hippocampus 35 97.04 Very High Very High Very High
Glutamate receptor 5 96.52 Very High Very High Very High
Inflammation 292 94.32 High High
Glutamate 5 92.76 High High
Neurotransmitter 6 92.36 High High
Inflammatory mediators 14 91.88 High High
aspirin 172 90.68 High High
Disease Link Frequency Relevance Heat
Death 46 99.96 Very High Very High Very High
Disease 80 99.72 Very High Very High Very High
Convulsion 25 99.68 Very High Very High Very High
Rheumatoid Arthritis 107 99.40 Very High Very High Very High
Leukemia 9 99.40 Very High Very High Very High
Adhesions 267 96.08 Very High Very High Very High
Skin Cancer 2 96.00 Very High Very High Very High
Hyperglycemia 39 95.76 Very High Very High Very High
Melanoma 1 94.76 High High
INFLAMMATION 354 94.32 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Selective addition of mere antisense RelA p65 had a moderate inhibitory effect, no effect was documented after selective adding of antisense NF-?
Positive_regulation (antisense) of p65 in mere
1) Confidence 0.46 Published 2001 Journal BMC Mol Biol Section Body Doc Link PMC48145 Disease Relevance 0.08 Pain Relevance 0
B1 p50 oligonucleotides had no effect. 3) Simultaneous incubation with antisense RelA p65 and NF-?
Positive_regulation (antisense) of p65
2) Confidence 0.46 Published 2001 Journal BMC Mol Biol Section Body Doc Link PMC48145 Disease Relevance 0 Pain Relevance 0
Incubation of HUVEC with antisense RelA p65 oligonucleotide caused a moderate reduction of the expression of ICAM-1 (Fig. 4A).
Positive_regulation (antisense) of RelA
3) Confidence 0.46 Published 2001 Journal BMC Mol Biol Section Body Doc Link PMC48145 Disease Relevance 0 Pain Relevance 0
Expression of ICAM-1 was 90, 80, 63, and 49% after incubation with antisense RelA p65 and NF-?
Positive_regulation (antisense) of RelA
4) Confidence 0.46 Published 2001 Journal BMC Mol Biol Section Body Doc Link PMC48145 Disease Relevance 0 Pain Relevance 0
The expression of ICAM-1 was 102, 83, and 85% after incubation with antisense RelA p65 and NF-?
Positive_regulation (antisense) of p65
5) Confidence 0.46 Published 2001 Journal BMC Mol Biol Section Body Doc Link PMC48145 Disease Relevance 0 Pain Relevance 0
B1 p50 was almost twice as high as the effect after addition of mere antisense RelA p65.
Positive_regulation (antisense) of RelA in mere
6) Confidence 0.46 Published 2001 Journal BMC Mol Biol Section Body Doc Link PMC48145 Disease Relevance 0.12 Pain Relevance 0
Expression of ICAM-1 was 66, 71, and 75% after incubation with antisense RelA p65 oligonucleotide in a concentration of 1, 2, and 4 ?
Positive_regulation (incubation) of p65
7) Confidence 0.46 Published 2001 Journal BMC Mol Biol Section Body Doc Link PMC48145 Disease Relevance 0 Pain Relevance 0
Expression of ICAM-1 was 66, 71, and 75% after incubation with antisense RelA p65 oligonucleotide in a concentration of 1, 2, and 4 ?
Positive_regulation (incubation) of RelA
8) Confidence 0.46 Published 2001 Journal BMC Mol Biol Section Body Doc Link PMC48145 Disease Relevance 0 Pain Relevance 0
B1 p50 oligonucleotides had no effect. 3) Simultaneous incubation with antisense RelA p65 and NF-?
Positive_regulation (antisense) of RelA
9) Confidence 0.46 Published 2001 Journal BMC Mol Biol Section Body Doc Link PMC48145 Disease Relevance 0 Pain Relevance 0
Selective addition of mere antisense RelA p65 had a moderate inhibitory effect, no effect was documented after selective adding of antisense NF-?
Positive_regulation (antisense) of RelA in mere
10) Confidence 0.46 Published 2001 Journal BMC Mol Biol Section Body Doc Link PMC48145 Disease Relevance 0.08 Pain Relevance 0
Simultaneous adding of antisense RelA p65 and NF-?
Positive_regulation (antisense) of RelA
11) Confidence 0.46 Published 2001 Journal BMC Mol Biol Section Body Doc Link PMC48145 Disease Relevance 0 Pain Relevance 0
Incubation with antisense RelA p65 oligonucleotides had a moderate stimulatory effect on the expression of ICAM-1 (Fig. 4D).
Positive_regulation (antisense) of p65
12) Confidence 0.46 Published 2001 Journal BMC Mol Biol Section Body Doc Link PMC48145 Disease Relevance 0 Pain Relevance 0
After adding simultaneously antisense RelA p65 and NF-?
Positive_regulation (antisense) of p65
13) Confidence 0.46 Published 2001 Journal BMC Mol Biol Section Body Doc Link PMC48145 Disease Relevance 0.10 Pain Relevance 0
B can be inhibited by antisense RelA p65 and NF-?
Positive_regulation (antisense) of p65
14) Confidence 0.46 Published 2001 Journal BMC Mol Biol Section Body Doc Link PMC48145 Disease Relevance 0.06 Pain Relevance 0.12
Furthermore in HCPSMC no inhibitory effect was found after selective addition of antisense RelA p65 or NF-?
Positive_regulation (antisense) of p65
15) Confidence 0.46 Published 2001 Journal BMC Mol Biol Section Body Doc Link PMC48145 Disease Relevance 0.05 Pain Relevance 0.03
No inhibitory effect was seen after selective addition of antisense RelA p65 and NF-?
Positive_regulation (antisense) of RelA
16) Confidence 0.46 Published 2001 Journal BMC Mol Biol Section Body Doc Link PMC48145 Disease Relevance 0.06 Pain Relevance 0
The expression of ICAM-1 was 102, 83, and 85% after incubation with antisense RelA p65 and NF-?
Positive_regulation (antisense) of RelA
17) Confidence 0.46 Published 2001 Journal BMC Mol Biol Section Body Doc Link PMC48145 Disease Relevance 0 Pain Relevance 0
No inhibitory effect was seen after selective addition of antisense RelA p65 and NF-?
Positive_regulation (antisense) of p65
18) Confidence 0.46 Published 2001 Journal BMC Mol Biol Section Body Doc Link PMC48145 Disease Relevance 0.06 Pain Relevance 0
The inhibition of ICAM-1 expression in HUVEC and HCAEC after simultaneous addition of antisense RelA p65 and NF-?
Positive_regulation (antisense) of RelA
19) Confidence 0.46 Published 2001 Journal BMC Mol Biol Section Body Doc Link PMC48145 Disease Relevance 0.07 Pain Relevance 0
Simultaneous adding of antisense RelA p65 and NF-?
Positive_regulation (antisense) of RelA
20) Confidence 0.46 Published 2001 Journal BMC Mol Biol Section Body Doc Link PMC48145 Disease Relevance 0 Pain Relevance 0

General Comments

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