INT73802

Context Info Confidence 0.60 First Reported 1998 Last Reported 2010 Negated 1 Speculated 2 Reported most in Abstract Documents 17 Total Number 19 Disease Relevance 8.72 Pain Relevance 3.51

extracellular space (Selp) nucleolus (Selp) nucleus (Selp) cytoplasm (Selp)

Anatomy Link Frequency plasma 3 coronary artery 1 endothelial cell 1 coronary sinus 1 platelet 1 Selp (Rattus norvegicus)

Pain Link Frequency Relevance Heat Inflammatory marker 14 100.00 chemokine 5 100.00 Versed 3 100.00 Angina 45 99.88 withdrawal 14 98.80 Inflammation 87 98.04 Inflammatory response 2 93.84 noradrenaline 9 83.56 aspirin 21 83.40 cytokine 10 81.28

Disease Link Frequency Relevance Heat INFLAMMATION 106 100.00 Adhesions 15 100.00 Sleep Disorders 9 100.00 Heart Rate Under Development 3 100.00 Coronary Artery Disease 9 99.96 Cv General 3 Under Development 37 99.88 Myocardial Infarction 33 99.08 Angina 6 96.12 Cardiovascular Disease 14 95.76 Thrombosis 11 91.16

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

We sought to test the hypothesis that the model of flow cytometer represents another variable affecting P-selectin measurements.

Regulation (affecting) of P-selectin

1) Confidence 0.60 Published 1999 Journal Thromb. Res. Section Abstract Doc Link 10554084 Disease Relevance 0.50 Pain Relevance 0.21

Whether this variant affects the properties of the P-selectin protein in a way which is compatible with this hypothesis needs to be checked experimentally.

Regulation (affects) of P-selectin protein

2) Confidence 0.54 Published 1998 Journal Hum. Mol. Genet. Section Abstract Doc Link 9668170 Disease Relevance 0.37 Pain Relevance 0

Similar changes in P-selectin levels were observed in the two groups (9.40 +/- 1.25 ng/mL vs. 8.90 +/- 1.34 ng/mL in the control group, and 9.56 +/- 1.16 ng/mL vs. 7.80 +/- 0.98 ng/mL in the trial group).

Regulation (changes) of P-selectin

3) Confidence 0.42 Published 2007 Journal J Altern Complement Med Section Body Doc Link 17480139 Disease Relevance 0.05 Pain Relevance 0

For some experiments, a blocking MAb directed at either ICAM-1 (1A29) or P-selectin (RMP-1) or their isotype-matched controls was injected intravenously 10 min before Indo administration.

Regulation (directed) of P-selectin

4) Confidence 0.41 Published 1998 Journal Am. J. Physiol. Section Abstract Doc Link 9486176 Disease Relevance 0.48 Pain Relevance 0.29

Similar changes of P-selectin levels were observed in both groups (9.40 +/- 1.25 ng/mL versus 8.90 +/- 1.34 ng/mL in the control group and 9.56 +/- 1.16 ng/mL versus 7.80 +/- 0.98 ng/mL in the trial group).

Regulation (changes) of P-selectin

5) Confidence 0.31 Published 2007 Journal J Altern Complement Med Section Body Doc Link 17604562 Disease Relevance 0.05 Pain Relevance 0

Four polymorphisms (Ser290Asn, Asn562Asp, Leu599Val and Thr715Pro) predicted a change in the amino acid sequence of the P-selectin protein.

Regulation (change) of P-selectin protein

6) Confidence 0.24 Published 1998 Journal Hum. Mol. Genet. Section Abstract Doc Link 9668170 Disease Relevance 0.70 Pain Relevance 0.08

Platelet activation in different clinical forms of the coronary artery disease (role of P-selectin and others platelet markers in stable and unstable angina).

Regulation (role) of P-selectin in coronary artery associated with angina and coronary artery disease

7) Confidence 0.14 Published 2006 Journal Arq. Bras. Cardiol. Section Title Doc Link 17128313 Disease Relevance 0.20 Pain Relevance 0.10

There was no significant treatment effect on von Willebrand factor or soluble P-selectin.

Neg (no) Regulation (effect) of P-selectin

8) Confidence 0.11 Published 2001 Journal Rheumatology (Oxford) Section Body Doc Link 11561116 Disease Relevance 0 Pain Relevance 0

A possible mechanism by which Hypericum attenuates polymorphonuclear cells infiltration is by down-regulating adhesion molecules ICAM-1 and P-selectin as previous described [22].

Regulation (regulating) of P-selectin associated with adhesions

9) Confidence 0.11 Published 2010 Journal BMC Complement Altern Med Section Body Doc Link PMC3000377 Disease Relevance 0.70 Pain Relevance 0.27

OBJECTIVE: To explore the effect of Composite Salviae Dropping Pill (CSDP) on the level of alpha-granule membrane protein-140 (GMP-140) in unstable angina pectoris (UAP).

Regulation (effect) of alpha-granule membrane protein-140 associated with angina

10) Confidence 0.10 Published 2000 Journal Zhongguo Zhong Xi Yi Jie He Za Zhi Section Abstract Doc Link 11789221 Disease Relevance 0.35 Pain Relevance 0.35

Secondary endpoints included changes from baseline in plasma soluble P-selectin and hsCRP levels.

Regulation (changes) of P-selectin in plasma

11) Confidence 0.10 Published 2009 Journal J Thromb Thrombolysis Section Body Doc Link PMC2766044 Disease Relevance 0.08 Pain Relevance 0.15

This study was aimed to investigate the effect of sedation on plasma soluble P-selectin (sP-selectin) levels and initiation phase of coagulation following coronary intervention.

Spec (investigate) Regulation (effect) of sP-selectin in plasma associated with sleep disorders

12) Confidence 0.05 Published 2006 Journal Int. J. Clin. Pract. Section Abstract Doc Link 16700848 Disease Relevance 0.27 Pain Relevance 0.16

Effect of sedation on soluble P-selectin levels, coagulation and myocardial damage following a coronary intervention.

Regulation (Effect) of soluble P-selectin associated with versed and sleep disorders

13) Confidence 0.05 Published 2006 Journal Int. J. Clin. Pract. Section Title Doc Link 16700848 Disease Relevance 0.28 Pain Relevance 0.25

Changes in inflammatory markers such as sCD40L, soluble P-selectin and hsCRP over 4 weeks after withdrawal of clopidogrel are shown in Table 3 (medians and interquartile ranges) and as mean percentage changes from baseline levels obtained at 12 months after clopidogrel administration.

Regulation (Changes) of P-selectin associated with inflammatory marker and withdrawal

14) Confidence 0.04 Published 2009 Journal J Thromb Thrombolysis Section Body Doc Link PMC2766044 Disease Relevance 0.78 Pain Relevance 0.33

This study was aimed to investigate the effect of sedation on plasma soluble P-selectin (sP-selectin) levels and initiation phase of coagulation following coronary intervention.

Spec (investigate) Regulation (effect) of soluble P-selectin in plasma associated with sleep disorders

15) Confidence 0.04 Published 2006 Journal Int. J. Clin. Pract. Section Abstract Doc Link 16700848 Disease Relevance 0.27 Pain Relevance 0.16

We measured and compared the ratio of elevated levels of regulated on activation normally T-cell expressed and secreted (RANTES), monocytic chemotactic peptide-1 (MCP-1), soluble (s) P-selectin and sL-selectin after PCI.

Regulation (regulated) of P-selectin in T-cell

16) Confidence 0.03 Published 2006 Journal Platelets Section Abstract Doc Link 17127484 Disease Relevance 0.61 Pain Relevance 0.21

The levels of platelet-derived microparticles (PDMPs), platelet activation markers (P-selectin, CD63, and PAC-1 on activated platelets), and C-C chemokines (monocyte chemotactic peptide [MCP]-1 and regulated on activation normally T-cell expressed and secreted [RANTES] were measured and compared in patients with acute myocardial infarction (AMI) or stable pectoris angina.

Regulation (regulated) of P-selectin in platelet associated with chemokine, heart rate under development, angina and myocardial infarction

17) Confidence 0.03 Published 2002 Journal Clin. Appl. Thromb. Hemost. Section Abstract Doc Link 12361207 Disease Relevance 0.79 Pain Relevance 0.24

The role of cell adhesion molecules (CAMs), such as intercellular cell adhesion molecule-1 (ICAM-1), vascular endothelial cell adhesion molecule-1 (VCAM-1), E-selectin, and P-selectin, has been studied extensively in the process of inflammation.

Regulation (role) of P-selectin in endothelial cell associated with inflammation and adhesions

18) Confidence 0.03 Published 2007 Journal Curr. Med. Chem. Section Abstract Doc Link 17305540 Disease Relevance 1.01 Pain Relevance 0.14

In addition, plasma levels of the tissue factor, tissue factor pathway inhibitor, P-selectin, E-selectin and ICAM-1 were measured in the blood withdrawn from the coronary sinus in a subgroup of patients with unstable angina pectoris and stable coronary artery disease in which the difference between concentrations in the coronary sinus and systemic blood was calculated.

Regulation (measured) of P-selectin in coronary sinus associated with angina and coronary artery disease

19) Confidence 0.01 Published 2003 Journal Physiol Res Section Abstract Doc Link 14640893 Disease Relevance 1.24 Pain Relevance 0.56

General Comments

This test has worked.