INT73829

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Context Info
Confidence 0.61
First Reported 1997
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 41
Total Number 42
Disease Relevance 35.96
Pain Relevance 11.92

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (VCAM1) aging (VCAM1) cell adhesion (VCAM1)
plasma membrane (VCAM1)
Anatomy Link Frequency
endothelial cells 25
leucocytes 13
platelets 6
descending aorta 4
brain 2
VCAM1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 537 100.00 Very High Very High Very High
qutenza 20 100.00 Very High Very High Very High
cytokine 212 99.98 Very High Very High Very High
antagonist 60 99.92 Very High Very High Very High
substance P 76 99.84 Very High Very High Very High
Nicotine 30 99.42 Very High Very High Very High
Neuropeptide 34 99.26 Very High Very High Very High
rheumatoid arthritis 151 99.04 Very High Very High Very High
c fibre 12 98.80 Very High Very High Very High
Inflammatory response 77 97.92 Very High Very High Very High
Disease Link Frequency Relevance Heat
Adhesions 581 100.00 Very High Very High Very High
Convulsion 62 99.98 Very High Very High Very High
Arthritis 23 99.84 Very High Very High Very High
INFLAMMATION 603 99.68 Very High Very High Very High
Nicotine Addiction 574 99.12 Very High Very High Very High
Rheumatoid Arthritis 151 99.04 Very High Very High Very High
Increased Venous Pressure Under Development 289 98.44 Very High Very High Very High
Occupational Lung Diseases 10 97.62 Very High Very High Very High
Sepsis 147 97.52 Very High Very High Very High
Cancer 95 97.44 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Extravasation of particular subsets of leukocytes depends upon the regulated expression of cellular adhesion molecules such as VCAM-1 on microvascular endothelial cells.
Positive_regulation (depends) of Gene_expression (expression) of VCAM-1 in leukocytes associated with adhesions
1) Confidence 0.61 Published 1999 Journal J. Immunol. Section Abstract Doc Link 9973426 Disease Relevance 0.20 Pain Relevance 0.45
Increased HDMEC VCAM-1 mRNA expression was detected 1 h after the addition of SP, with peak mRNA increase at 6-9 h postinduction.
Positive_regulation (Increased) of Gene_expression (expression) of HDMEC VCAM-1 mRNA associated with substance p
2) Confidence 0.61 Published 1999 Journal J. Immunol. Section Abstract Doc Link 9973426 Disease Relevance 0.14 Pain Relevance 0.72
FACS studies demonstrated a 6.5-fold increase in endothelial cell surface VCAM-1 expression detectable 16 h after addition of SP, which was specifically blocked by a neurokinin-1 receptor antagonist.
Positive_regulation (increase) of Gene_expression (expression) of VCAM-1 in endothelial cell associated with antagonist and substance p
3) Confidence 0.61 Published 1999 Journal J. Immunol. Section Abstract Doc Link 9973426 Disease Relevance 0.12 Pain Relevance 0.72
These data indicate that SP is capable of directly and specifically up-regulating functional endothelial VCAM-1 expression and thus may play a key role in modulating certain inflammatory responses in the skin.
Positive_regulation (up-regulating) of Gene_expression (expression) of VCAM-1 in skin associated with inflammatory response and substance p
4) Confidence 0.50 Published 1999 Journal J. Immunol. Section Abstract Doc Link 9973426 Disease Relevance 0.10 Pain Relevance 0.61
Only substance P (SP) was found to be capable of inducing HDMEC VCAM-1 expression.
Positive_regulation (inducing) of Gene_expression (expression) of VCAM-1 associated with substance p
5) Confidence 0.50 Published 1999 Journal J. Immunol. Section Abstract Doc Link 9973426 Disease Relevance 0.15 Pain Relevance 0.67
VCAM-1 expression on human dermal microvascular endothelial cells is directly and specifically up-regulated by substance P.
Positive_regulation (up-regulated) of Gene_expression (expression) of VCAM-1 in endothelial cells associated with qutenza and substance p
6) Confidence 0.50 Published 1999 Journal J. Immunol. Section Title Doc Link 9973426 Disease Relevance 0.18 Pain Relevance 0.65
For example, VCAM-1 expression on endothelial cells is induced by interleukin-1?
Positive_regulation (by) of Gene_expression (expression) of VCAM-1 in endothelial cells
7) Confidence 0.50 Published 2004 Journal Journal of Korean Medical Science Section Body Doc Link PMC2816332 Disease Relevance 0.90 Pain Relevance 0.09
Increased concentrations of VCAM-1 may reflect increased expression of this molecule on the endothelial surface.
Positive_regulation (increased) of Gene_expression (expression) of VCAM-1
8) Confidence 0.46 Published 2004 Journal Journal of Korean Medical Science Section Body Doc Link PMC2816332 Disease Relevance 1.12 Pain Relevance 0.08
Likewise, the constitutively low expression of ICAM-1 and VCAM-1 is rapidly upregulated on the cytokine-activated cerebrovascular ECs facilitating adhesion and transmigration of leukocytes into the CNS [35,66,67].
Positive_regulation (upregulated) of Gene_expression (expression) of VCAM-1 in leukocytes associated with adhesions and cytokine
9) Confidence 0.43 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2819256 Disease Relevance 0.69 Pain Relevance 0.13
Hematein and probucol prevented the up-regulation of the vascular cell adhesion molecule-1 (VCAM-1) expression on the descending aorta induced by cholesterol diet.
Positive_regulation (up-regulation) of Gene_expression (expression) of VCAM-1 in descending aorta associated with adhesions
10) Confidence 0.42 Published 2001 Journal Atherosclerosis Section Abstract Doc Link 11689202 Disease Relevance 0.42 Pain Relevance 0.12
Multiple cutaneous sensory C-fiber-released neuropeptides were evaluated for their ability to induce VCAM-1 cell surface expression on HDMEC.
Positive_regulation (induce) of Gene_expression (expression) of VCAM-1 associated with c fibre and neuropeptide
11) Confidence 0.41 Published 1999 Journal J. Immunol. Section Abstract Doc Link 9973426 Disease Relevance 0.16 Pain Relevance 0.67
Increased VCAM-1 cell surface expression on SP-treated HDMEC resulted in a 4-fold increase in the functional binding of 51Cr-labeled MOLT-4 T cells.
Positive_regulation (Increased) of Gene_expression (expression) of VCAM-1 in T cells associated with substance p
12) Confidence 0.41 Published 1999 Journal J. Immunol. Section Abstract Doc Link 9973426 Disease Relevance 0.11 Pain Relevance 0.70
Nicotine has been shown to induce an increase in VCAM-1 mRNA synthesis, but not E-selectin, in primary human coronary artery endothelial cells, but a 1.6 fold elevation required 24 hr exposure to a concentration of nicotine as high as 10-5M (or 1.6 ?
Positive_regulation (increase) of Gene_expression (synthesis) of VCAM-1 mRNA in endothelial cells associated with nicotine
13) Confidence 0.40 Published 2003 Journal Tob Induc Dis Section Body Doc Link PMC2669563 Disease Relevance 1.58 Pain Relevance 0.15
Nicotine has been shown to induce an increase in VCAM-1 mRNA synthesis, but not E-selectin, in primary human coronary artery endothelial cells, but a 1.6 fold elevation required 24 hr exposure to a concentration of nicotine as high as 10-5M (or 1.6 ?
Positive_regulation (increase) of Gene_expression (synthesis) of VCAM-1 mRNA in endothelial cells associated with nicotine
14) Confidence 0.40 Published 2003 Journal Tob Induc Dis Section Body Doc Link PMC2671531 Disease Relevance 1.58 Pain Relevance 0.15
VCAM-1 expression was induced after 6 h of treatment with TNFalpha and IL-1beta on almost 100% of Schwann cells.
Positive_regulation (induced) of Gene_expression (expression) of VCAM-1 in Schwann cells
15) Confidence 0.40 Published 1999 Journal J. Neurol. Sci. Section Abstract Doc Link 10561528 Disease Relevance 0.71 Pain Relevance 0.35
Adams et al. [102] were able to show upregulation of ICAM-1 (but not VCAM-1 or E-selectin) expression on HUVECs exposed to smokers' serum, and to confirm increased monocyte-endothelium adhesion in smokers selected to exhibit no other major risk factor for vascular disease.
Positive_regulation (upregulation) of Gene_expression (expression) of VCAM-1 in monocyte associated with nicotine addiction, increased venous pressure under development and adhesions
16) Confidence 0.37 Published 2003 Journal Tob Induc Dis Section Body Doc Link PMC2669563 Disease Relevance 1.85 Pain Relevance 0.18
It is known that endothelial cell activation and VCAM-1 expression is induced mainly by IL-1b and TNF-?.
Positive_regulation (activation) of Gene_expression (expression) of VCAM-1 in endothelial cell
17) Confidence 0.37 Published 2002 Journal Respir Res Section Body Doc Link PMC150513 Disease Relevance 0.76 Pain Relevance 0.14
Hematein and probucol prevented the up-regulation of the vascular cell adhesion molecule-1 (VCAM-1) expression on the descending aorta induced by cholesterol diet.
Positive_regulation (up-regulation) of Gene_expression (expression) of vascular cell adhesion molecule-1 in descending aorta associated with adhesions
18) Confidence 0.37 Published 2001 Journal Atherosclerosis Section Abstract Doc Link 11689202 Disease Relevance 0.42 Pain Relevance 0.12
In addition, SP is able to directly activate HDMEC to express high levels of the important cellular adhesion molecule vascular cellular adhesion molecule 1 (VCAM-1).
Positive_regulation (activate) of Gene_expression (express) of VCAM-1 associated with adhesions and substance p
19) Confidence 0.36 Published 1997 Journal J. Investig. Dermatol. Symp. Proc. Section Abstract Doc Link 9487011 Disease Relevance 0.58 Pain Relevance 0.69
In addition, SP is able to directly activate HDMEC to express high levels of the important cellular adhesion molecule vascular cellular adhesion molecule 1 (VCAM-1).
Positive_regulation (activate) of Gene_expression (express) of vascular cellular adhesion molecule 1 associated with adhesions and substance p
20) Confidence 0.36 Published 1997 Journal J. Investig. Dermatol. Symp. Proc. Section Abstract Doc Link 9487011 Disease Relevance 0.58 Pain Relevance 0.69

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