INT73900

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Context Info
Confidence 0.33
First Reported 1997
Last Reported 2005
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 1.13
Pain Relevance 0.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
vessels 1
Col4a2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
fibrosis 3 98.60 Very High Very High Very High
abdominal pain 1 56.28 Quite High
Chronic pancreatitis 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pressure And Volume Under Development 2 99.20 Very High Very High Very High
Fibrosis 3 98.60 Very High Very High Very High
Congenital Anomalies 1 92.00 High High
Infection 2 90.40 High High
Hepatomegaly 2 85.48 High High
Splenomegaly 2 84.40 Quite High
Diarrhoea 1 57.80 Quite High
Abdominal Pain 1 56.28 Quite High
Colitis 1 55.28 Quite High
Pancreatitis 2 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CONCLUSIONS: Our findings indicate that a long-term increase in gelatinolytic activity of active MMP-2 in Arg-induced pancreatitis causes continuous disorganization of type IV collagen in the BM and progressive acinar atrophy, whereas a transient increase in gelatinolytic activity of active MMP-2 is involved in the regeneration of type IV collagen structure in the BM and recovery from acinar injury.


Positive_regulation (causes) of type IV collagen
1) Confidence 0.33 Published 2005 Journal Pancreas Section Body Doc Link 16258372 Disease Relevance 0 Pain Relevance 0
Serum procollagen-IV-peptide and gamma-glutamyl-transferase levels were increased in persons with severe periportal fibrosis, irregular liver texture of portofugal collateral vessels.
Positive_regulation (increased) of Serum procollagen-IV-peptide in vessels associated with fibrosis
2) Confidence 0.13 Published 1997 Journal Trop. Med. Int. Health Section Abstract Doc Link 9491101 Disease Relevance 1.13 Pain Relevance 0.19

General Comments

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