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Context Info
Confidence 0.77
First Reported 1998
Last Reported 2011
Negated 2
Speculated 6
Reported most in Abstract
Documents 58
Total Number 64
Disease Relevance 26.59
Pain Relevance 15.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Esr1) nucleus (Esr1) enzyme binding (Esr1)
DNA binding (Esr1) protein complex (Esr1) transcription factor binding (Esr1)
Anatomy Link Frequency
neurons 8
TMJ 7
endometrium 3
MCF-7 2
hypothalamus 2
Esr1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 93 100.00 Very High Very High Very High
Neuropeptide 13 100.00 Very High Very High Very High
nociceptor 9 100.00 Very High Very High Very High
member 8 2 100.00 Very High Very High Very High
Locus ceruleus 40 99.98 Very High Very High Very High
Dorsal horn 7 99.98 Very High Very High Very High
Cholecystokinin 5 99.92 Very High Very High Very High
metalloproteinase 30 99.84 Very High Very High Very High
Inflammation 185 99.80 Very High Very High Very High
GABAergic 10 99.72 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress Incontinence 12 99.98 Very High Very High Very High
Arthritis 90 99.84 Very High Very High Very High
Endometriosis (extended) 50 99.84 Very High Very High Very High
Nociception 14 99.84 Very High Very High Very High
INFLAMMATION 188 99.80 Very High Very High Very High
Ganglion Cysts 11 99.72 Very High Very High Very High
Temporomandibular Joint Syndrome 340 99.68 Very High Very High Very High
Cancer 84 99.50 Very High Very High Very High
Breast Cancer 92 99.46 Very High Very High Very High
Osteomyelitis 148 99.28 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Expression of estrogen receptor alpha (ER alpha) in the rat temporomandibular joint.
Gene_expression (Expression) of estrogen receptor alpha in temporomandibular joint associated with snapping jaw
1) Confidence 0.77 Published 2003 Journal The anatomical record. Part A, Discoveries in molecular, cellular, and evolutionary biology Section Title Doc Link 12973717 Disease Relevance 0.85 Pain Relevance 0.44
Expression of estrogen receptor alpha (ER alpha) in the rat temporomandibular joint.
Gene_expression (Expression) of ER alpha in temporomandibular joint associated with snapping jaw
2) Confidence 0.77 Published 2003 Journal The anatomical record. Part A, Discoveries in molecular, cellular, and evolutionary biology Section Title Doc Link 12973717 Disease Relevance 0.86 Pain Relevance 0.44
In searching for the molecular mechanisms leading from the initial activation of the estrogen receptor to the final formation of new dendritic spines, we found that estradiol acts on GABAergic interneurons expressing the estrogen receptor by decreasing their inhibitory tone.
Gene_expression (expressing) of estrogen receptor in interneurons associated with gabaergic
3) Confidence 0.75 Published 2001 Journal Horm Behav Section Abstract Doc Link 11534976 Disease Relevance 0 Pain Relevance 0.23
These findings show that nociceptive-responsive neurons in the medullary dorsal horn express ERalpha, thus providing a possible morphological basis for the hypothesis that estrogens directly regulate pain transmission at this level.
Gene_expression (express) of ERalpha in neurons associated with nociception, pain and dorsal horn
4) Confidence 0.75 Published 2010 Journal Eur J Pain Section Abstract Doc Link 19525133 Disease Relevance 0.63 Pain Relevance 0.37
Interaction of thyroxine and estrogen on the expression of estrogen receptor alpha, cholecystokinin, and preproenkephalin messenger ribonucleic acid in the limbic-hypothalamic circuit.
Gene_expression (expression) of estrogen receptor alpha associated with enkephalin and cholecystokinin
5) Confidence 0.71 Published 1998 Journal Endocrinology Section Title Doc Link 9492057 Disease Relevance 0.08 Pain Relevance 0.44
Moreover, progesterone could impact estrogen receptor expression and interact with 17 ?
Gene_expression (expression) of estrogen receptor
6) Confidence 0.71 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2811708 Disease Relevance 0.42 Pain Relevance 0.39
The objectives of this study were to detail the activation of DRG and spinal neurons of the L6/S1 levels that are stimulated at late pregnancy, verify hypothalamic projections of activated spinal neurons, and determine whether activated neurons express estrogen receptor-alpha (ERalpha).
Gene_expression (express) of estrogen receptor-alpha in neurons
7) Confidence 0.69 Published 2005 Journal J. Neurosci. Res. Section Abstract Doc Link 16273543 Disease Relevance 0 Pain Relevance 0.08
The objectives of this study were to detail the activation of DRG and spinal neurons of the L6/S1 levels that are stimulated at late pregnancy, verify hypothalamic projections of activated spinal neurons, and determine whether activated neurons express estrogen receptor-alpha (ERalpha).
Gene_expression (express) of ERalpha in neurons
8) Confidence 0.69 Published 2005 Journal J. Neurosci. Res. Section Abstract Doc Link 16273543 Disease Relevance 0 Pain Relevance 0.08
Some DRG neurons expressing PCREB also expressed ERalpha, and some spinal neurons activated at parturition projected axons to the hypothalamus and expressed ERalpha.
Gene_expression (expressed) of ERalpha in hypothalamus
9) Confidence 0.69 Published 2005 Journal J. Neurosci. Res. Section Abstract Doc Link 16273543 Disease Relevance 0 Pain Relevance 0.25
Some DRG neurons expressing PCREB also expressed ERalpha, and some spinal neurons activated at parturition projected axons to the hypothalamus and expressed ERalpha.
Gene_expression (expressed) of ERalpha in hypothalamus
10) Confidence 0.69 Published 2005 Journal J. Neurosci. Res. Section Abstract Doc Link 16273543 Disease Relevance 0 Pain Relevance 0.24
In this study we examined the expression of ER alpha protein and mRNA in the TMJ of adult male rats by immunocytochemistry and in situ hybridization histochemistry.
Spec (examined) Gene_expression (expression) of ER alpha protein in TMJ associated with snapping jaw
11) Confidence 0.67 Published 2003 Journal The anatomical record. Part A, Discoveries in molecular, cellular, and evolutionary biology Section Abstract Doc Link 12973717 Disease Relevance 0.87 Pain Relevance 0.49
Estrogen receptor-alpha expression in nociceptive-responsive neurons in the medullary dorsal horn of the female rat.
Gene_expression (expression) of Estrogen receptor in neurons associated with nociception, nociceptor and dorsal horn
12) Confidence 0.58 Published 2010 Journal Eur J Pain Section Title Doc Link 19525133 Disease Relevance 0.59 Pain Relevance 0.44
Estrogen and inflammation modulate estrogen receptor alpha expression in specific tissues of the temporomandibular joint

Background

Gene_expression (expression) of estrogen receptor in temporomandibular joint associated with snapping jaw and inflammation
13) Confidence 0.55 Published 2009 Journal Reprod Biol Endocrinol Section Title Doc Link PMC2811708 Disease Relevance 1.02 Pain Relevance 0.89
Cells expressing the estrogen receptor ERalpha are present in the temporomandibular joint (TMJ) but changes in expression due to estrogen and inflammation have not been characterized.
Gene_expression (expressing) of ERalpha in TMJ associated with snapping jaw and inflammation
14) Confidence 0.55 Published 2009 Journal Reprod Biol Endocrinol Section Abstract Doc Link PMC2811708 Disease Relevance 0.91 Pain Relevance 0.78
In conclusion, inflammation and 17 beta-estradiol can modulate ERalpha expression in the TMJ but the effects are tissue specific.



Gene_expression (expression) of ERalpha associated with snapping jaw and inflammation
15) Confidence 0.55 Published 2009 Journal Reprod Biol Endocrinol Section Abstract Doc Link PMC2811708 Disease Relevance 0.79 Pain Relevance 0.59
To determine whether an increase in the expression per cell results in a higher expression of estrogen receptor, we needed to quantitate the fluorescent signal in each cell.
Gene_expression (expression) of estrogen receptor
16) Confidence 0.55 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2811708 Disease Relevance 0.12 Pain Relevance 0.12
In this study, ERalpha protein content and the number of cells expressing ERalpha was measured in 17 beta-estradiol-treated rats after inflammation was induced in the TMJ.


Gene_expression (expressing) of ERalpha in TMJ associated with snapping jaw and inflammation
17) Confidence 0.55 Published 2009 Journal Reprod Biol Endocrinol Section Abstract Doc Link PMC2811708 Disease Relevance 1.02 Pain Relevance 0.89
Additionally, we investigated whether arcuate prodynorphin-ir (immunoreactive) neurons expressed the neurokinin 3 receptor (NK3R) or nuclear estrogen receptor-alpha (ERalpha).
Spec (whether) Gene_expression (expressed) of ERalpha in neurons
18) Confidence 0.55 Published 2006 Journal J. Comp. Neurol. Section Abstract Doc Link 16917850 Disease Relevance 0 Pain Relevance 0.08
Additionally, we investigated whether arcuate prodynorphin-ir (immunoreactive) neurons expressed the neurokinin 3 receptor (NK3R) or nuclear estrogen receptor-alpha (ERalpha).
Spec (whether) Gene_expression (expressed) of estrogen receptor-alpha in neurons
19) Confidence 0.55 Published 2006 Journal J. Comp. Neurol. Section Abstract Doc Link 16917850 Disease Relevance 0 Pain Relevance 0.08
and estrogen receptor alpha (ER?)
Gene_expression (alpha) of estrogen receptor
20) Confidence 0.50 Published 2008 Journal PPAR Research Section Body Doc Link PMC2519140 Disease Relevance 0.21 Pain Relevance 0

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