INT73981

Context Info Confidence 0.75 First Reported 1997 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 18 Total Number 20 Disease Relevance 5.69 Pain Relevance 3.72

protein folding (Hspd1) cytosol (Hspd1) mitochondrion (Hspd1) extracellular space (Hspd1) Golgi apparatus (Hspd1) cytoplasm (Hspd1)

Anatomy Link Frequency macrophages 2 liver 2 brain 2 plasma 1 cartilage 1 Hspd1 (Mus musculus)

Pain Link Frequency Relevance Heat cytokine 80 100.00 antagonist 16 99.28 substance P 2 98.70 Paracetamol 38 98.64 fluoxetine 3 98.30 antidepressant 4 95.92 Inflammation 284 92.88 depression 1 84.88 monoamine 4 83.52 cerebral cortex 7 81.20

Disease Link Frequency Relevance Heat Shock 238 100.00 Tinea 3 100.00 Stress 148 98.64 INFLAMMATION 292 92.88 Sprains And Strains 31 92.56 Osteoarthritis 19 86.68 Ataxia 4 85.12 Depression 1 84.88 Apoptosis 19 84.84 Cancer 111 82.64

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Mutation

Event

Anatomy

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Speculation

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Disease term

production in murine macrophages and in mHSP60-expressing COS1 cells, were shown to differentially activate APC function.

Gene_expression (expressing) of HSP60 in macrophages

1) Confidence 0.75 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2913853 Disease Relevance 0.40 Pain Relevance 0.26

production in murine macrophages and in mHSP60-expressing COS1 cells, were shown to differentially activate APC function.

Gene_expression (expressing) of HSP60 in macrophages

2) Confidence 0.65 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2913853 Disease Relevance 0.40 Pain Relevance 0.26

(40), Hsp25, Hsp70, Hsp86, Hsp110 but not Hsp65 were observed in wild-type mice after HS; the increases in all of the proteins were PPAR?

Gene_expression (observed) of Hsp65 associated with shock

3) Confidence 0.62 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2823686 Disease Relevance 0.63 Pain Relevance 0

RESULTS: The mRNA levels of HSP47, HSP70, HSP86, IL-6, and IFN-gamma were up-regulated in the cartilage of C57 black mice, whereas, the level of expression of HSP32, HSP60, HSP84 and IL-1 beta remained unchanged.

Gene_expression (expression) of HSP60 in cartilage

4) Confidence 0.58 Published 1997 Journal Osteoarthr. Cartil. Section Body Doc Link 9497939 Disease Relevance 0.07 Pain Relevance 0

Furthermore, the expression of IL-1 beta, IL-6, TNF-alpha and IFN-gamma mRNA was associated with expression of HSP60, HSP47, HSP70 and HSP70/HSP86 mRNA, respectively.

Gene_expression (expression) of HSP60

5) Confidence 0.58 Published 1997 Journal Osteoarthr. Cartil. Section Body Doc Link 9497939 Disease Relevance 0.06 Pain Relevance 0

We examined changes in survival ratio, plasma APAP level and alanine aminotransferase (ALT) activity, and hepatic reduced glutathione (GSH), HSP25, HSP60, HSC70 and HSP70i levels following treatment of mice with APAP (500 mg/kg, p.o.).

Gene_expression (levels) of HSP60 in plasma associated with paracetamol

6) Confidence 0.57 Published 2004 Journal Life Sci. Section Abstract Doc Link 15010265 Disease Relevance 0.32 Pain Relevance 0.92

Previously, S-(1,1,2,2-tetrafluoroethyl)-l-cysteine (TFEC) was shown to mediate cytotoxicity by covalently modifying a well-defined group of intramitochondrial proteins including aconitase, alpha-ketoglutarate dehydrogenase (alphaKGDH) subunits, heat shock protein 60 (HSP60) and mitochondrial HSP70 (mtHSP70).

Gene_expression (group) of heat shock protein 60 associated with shock

7) Confidence 0.56 Published 2006 Journal Biochem. Pharmacol. Section Abstract Doc Link 16678137 Disease Relevance 0.17 Pain Relevance 0.07

Previously, S-(1,1,2,2-tetrafluoroethyl)-l-cysteine (TFEC) was shown to mediate cytotoxicity by covalently modifying a well-defined group of intramitochondrial proteins including aconitase, alpha-ketoglutarate dehydrogenase (alphaKGDH) subunits, heat shock protein 60 (HSP60) and mitochondrial HSP70 (mtHSP70).

Gene_expression (group) of HSP60 associated with shock

8) Confidence 0.56 Published 2006 Journal Biochem. Pharmacol. Section Abstract Doc Link 16678137 Disease Relevance 0.17 Pain Relevance 0.07

Among the more highly expressed are Hspd1, Hspe1, and Cct subunits 2, 4, 5, and 7.

Gene_expression (expressed) of Hspd1

9) Confidence 0.52 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965669 Disease Relevance 0.26 Pain Relevance 0

For example, the inducible Hsp70 (Hspa1a) is present at extremely low levels in brain, whereas the constitutively expressed Hsp90, Hsc70 an Hsp60 are easily detected [90].

Gene_expression (expressed) of Hsp60 in brain

10) Confidence 0.52 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965669 Disease Relevance 0.06 Pain Relevance 0.16

For example, the inducible Hsp70 (Hspa1a) is present at extremely low levels in brain, whereas the constitutively expressed Hsp90, Hsc70 an Hsp60 are easily detected [90].

Gene_expression (detected) of Hsp60 in brain

11) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965669 Disease Relevance 0.06 Pain Relevance 0.16

Messenger RNAs (mRNAs) for HSPs (HSP32, HSP47, HSP60, HSP70, HSP84 and HSP86) and cytokines [interleukin-1 beta (IL-1 beta), interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha) and interferon-gamma (IFN-gamma)] were detected by reverse transcription-polymerase chain reaction (RT-PCR).

Gene_expression (detected) of HSP60

12) Confidence 0.45 Published 1997 Journal Osteoarthr. Cartil. Section Body Doc Link 9497939 Disease Relevance 0.09 Pain Relevance 0

The aim of the present study was to assess the contribution of the level of expression of heat shock protein 25 (HSP25), 60 (HSP60), 70 (HSC70) and 70i (HSP70i) in mouse livers after a lethal dose of acetaminophen (APAP) to their survival.

Gene_expression (expression) of HSP60 in livers associated with paracetamol and shock

13) Confidence 0.44 Published 2004 Journal Life Sci. Section Abstract Doc Link 15010265 Disease Relevance 0.30 Pain Relevance 0.68

In one study, it was shown that Snell dwarf liver tissue expressed less HSP70, HSP90, and HSP60 than was found in wild-type mice (Dozmorov et al. 2002).

Gene_expression (expressed) of HSP60 in liver

14) Confidence 0.40 Published 2006 Journal Age (Dordr) Section Body Doc Link PMC2464727 Disease Relevance 0.72 Pain Relevance 0

Both fluoxetine and the substance P receptor (NK(1)R) antagonist (SPA) L-000760735 altered cortical expression of multiple heat shock protein 60 forms along with neurofilaments and related proteins that are critical determinants of synaptic structure and function.

Gene_expression (expression) of heat shock protein 60 associated with antagonist, shock, substance p and fluoxetine

15) Confidence 0.39 Published 2004 Journal Brain Res. Section Abstract Doc Link 14988027 Disease Relevance 0.18 Pain Relevance 0.62

Indeed, only HSP60 was able to stimulate the production of IFN?

Gene_expression (only) of HSP60

16) Confidence 0.32 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2913853 Disease Relevance 0.30 Pain Relevance 0.23

The first report of a putative endogenous activator of TLRs dates back to 2000, when heat shock protein 60 (HSP60) was shown to induce cytokine synthesis through TLR4 activation [12].

Gene_expression (synthesis) of HSP60 associated with shock and cytokine

17) Confidence 0.32 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2913853 Disease Relevance 0.79 Pain Relevance 0.25

Also, Pam3Cys promoted the expressions of IL-10, IL-13 and HSP60 (Fig.

Gene_expression (expressions) of HSP60

18) Confidence 0.31 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2716531 Disease Relevance 0.06 Pain Relevance 0.04

Some of the PrP-interacting proteins describe before and summarized in recent reviews [36], [37], including for instance Tubulin, Hsp60 and Laminin, were detected in the specific as well as unspecific elution fraction of our approach and therefore not included into the list of possible candidates.

Gene_expression (detected) of Hsp60

19) Confidence 0.31 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2635968 Disease Relevance 0.17 Pain Relevance 0

The plasmid pDNAX (pVAX-Hsp60 TM814), encoding the heat shock protein 60 (Hsp60) from Trichophyton mentagrophytes [24] and the plasmid pLacZ (pcDNA3.1/LacZ), expressing ?

Gene_expression (expressing) of pVAX-Hsp60 TM814 associated with tinea and shock

20) Confidence 0.02 Published 2008 Journal Genet Vaccines Ther Section Body Doc Link PMC2542361 Disease Relevance 0.49 Pain Relevance 0

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