INT7399

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Context Info
Confidence 0.59
First Reported 1992
Last Reported 1999
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 0.35
Pain Relevance 1.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Grpr) signal transducer activity (Grpr)
Anatomy Link Frequency
cholinergic neurons 1
nerve 1
neurons 1
uterine 1
Grpr (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Enkephalin 2 100.00 Very High Very High Very High
substance P 1 99.94 Very High Very High Very High
Dismenorea 2 95.72 Very High Very High Very High
antagonist 7 95.64 Very High Very High Very High
Somatostatin 14 93.44 High High
tetrodotoxin 6 83.88 Quite High
agonist 4 83.36 Quite High
Neuropeptide 2 81.68 Quite High
Disease Link Frequency Relevance Heat
Bordatella Infection 1 98.36 Very High Very High Very High
Dysmenorrhea 2 95.72 Very High Very High Very High
Carcinoma 1 85.32 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Substance P-, bombesin- and enkephalin-like immunoreactivity was increased in local ganglionic cells and glandular nerve fibres.
Positive_regulation (increased) of bombesin in nerve associated with enkephalin and substance p
1) Confidence 0.59 Published 1999 Journal Acta Oncol Section Abstract Doc Link 10665767 Disease Relevance 0.09 Pain Relevance 0.22
The results demonstrate that rat myometrium expresses functional GRP-preferring Bn receptors whose activation stimulates the phospholipase C pathway, pertussis toxin-insensitive event that contributes to Bn-mediated uterine contractions.
Positive_regulation (activation) of GRP-preferring in uterine associated with bordatella infection and dismenorea
2) Confidence 0.41 Published 1993 Journal Am. J. Physiol. Section Abstract Doc Link 8279518 Disease Relevance 0.19 Pain Relevance 0.15
Peptone stimulates gastrin secretion from the stomach by activating bombesin/GRP and cholinergic neurons.
Positive_regulation (activating) of bombesin in cholinergic neurons
3) Confidence 0.12 Published 1992 Journal Am. J. Physiol. Section Title Doc Link 1348906 Disease Relevance 0 Pain Relevance 0.53
The results indicate that peptone stimulates gastrin secretion by activating stimulatory cholinergic and bombesin/GRP neurons.
Positive_regulation (activating) of bombesin in neurons
4) Confidence 0.12 Published 1992 Journal Am. J. Physiol. Section Abstract Doc Link 1348906 Disease Relevance 0 Pain Relevance 0.61
The removal of extracellular Ca2+ or the addition of nifedipine inhibited (35%) InsP production due to bombesin and ET-1.
Positive_regulation (due) of bombesin
5) Confidence 0.02 Published 1999 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 10215683 Disease Relevance 0.07 Pain Relevance 0.18

General Comments

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