INT74064

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Context Info
Confidence 0.75
First Reported 1998
Last Reported 2010
Negated 2
Speculated 1
Reported most in Abstract
Documents 9
Total Number 10
Disease Relevance 4.14
Pain Relevance 2.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (SPG21) endosome (SPG21) cell death (SPG21)
Golgi apparatus (SPG21) nucleus (SPG21) cytoplasm (SPG21)
Anatomy Link Frequency
mast cell 8
colons 1
bladder 1
SPG21 (Homo sapiens)
Pain Link Frequency Relevance Heat
interstitial cystitis 14 98.40 Very High Very High Very High
anesthesia 8 98.40 Very High Very High Very High
fibrosis 2 95.20 Very High Very High Very High
Pain 3 89.52 High High
opiate 2 87.88 High High
palliative 1 71.92 Quite High
Lasting pain 1 71.12 Quite High
transdermal 1 69.04 Quite High
Morphine 1 66.36 Quite High
Analgesic 1 64.44 Quite High
Disease Link Frequency Relevance Heat
Anaphylaxis 6 99.16 Very High Very High Very High
Interstitial Cystitis 14 98.40 Very High Very High Very High
Hyperplasia 1 97.80 Very High Very High Very High
Fibrosis 2 95.20 Very High Very High Very High
Acute Chest Syndrome 2 93.72 High High
Pain 4 89.52 High High
Overdose 5 88.24 High High
Overactive Bladder 1 87.48 High High
Leukemia 1 87.16 High High
Hodgkin's Disease 2 86.80 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
RESULTS: Significantly lower expression of PAR-1 and higher expression of mast cell tryptase was detected in the colons of patients, with statistically unchanged expression of PAR-2.
Gene_expression (expression) of mast in colons
1) Confidence 0.75 Published 2009 Journal J. Gastroenterol. Section Body Doc Link 19430717 Disease Relevance 0.08 Pain Relevance 0
Seven of 143 patients whose mast cell tryptase concentrations were not increased at appropriate sampling times had positive tests for IgE antibodies, and in 33 of 158 patients with increased mast cell tryptase concentrations no IgE antibodies were detected.
Neg (no) Gene_expression (detected) of mast in mast cell
2) Confidence 0.65 Published 1998 Journal Br J Anaesth Section Abstract Doc Link 9505773 Disease Relevance 0.22 Pain Relevance 0
The mast cell tryptase was also significantly elevated at 76 microg/L, (Normal 2-14 microg/L).
Gene_expression (The) of mast in mast cell
3) Confidence 0.65 Published 2009 Journal Am J Forensic Med Pathol Section Abstract Doc Link 19465816 Disease Relevance 0.96 Pain Relevance 0.48
Multifocal accumulations of mast cells were strongly positive with mast cell tryptase and CD117 on immunohistochemical staining, though no metachromasia was identified in Giemsa and Toluidine Blue stained aspirates and tissue sections, probably due to hypo-/agranulation of mast cells.
Neg (no) Gene_expression (positive) of mast in mast cell
4) Confidence 0.65 Published 2007 Journal Dis. Markers Section Abstract Doc Link 17473386 Disease Relevance 1.09 Pain Relevance 0.16
BACKGROUND: Mast cell tryptase is used clinically in the evaluation of anaphylaxis during anesthesia, because symptoms and signs of anaphylaxis are often masked by the effect of anesthesia.
Gene_expression (used) of Mast in Mast cell associated with anesthesia and anaphylaxis
5) Confidence 0.65 Published 2010 Journal Anesthesiology Section Abstract Doc Link 20395827 Disease Relevance 0.20 Pain Relevance 0.43
MAIN OUTCOME MEASURES: Standardized skin examination, skin biopsy with mast cell count, urinary levels of leukotriene E4 (LTE4), and serum levels of mast cell tryptase.
Gene_expression (levels) of mast in mast cell
6) Confidence 0.58 Published 2003 Journal Arch Dermatol Section Body Doc Link 14676074 Disease Relevance 0.12 Pain Relevance 0
Basal urinary levels of LTE4 and serum mast cell tryptase were increased in aspirin-sensitive compared with aspirin-tolerant patients.
Gene_expression (levels) of mast in mast cell
7) Confidence 0.58 Published 2003 Journal Arch Dermatol Section Body Doc Link 14676074 Disease Relevance 0 Pain Relevance 0
Altered expression of bladder mast cell growth factor receptor (c-kit) in interstitial cystitis.
Gene_expression (expression) of mast in mast cell associated with interstitial cystitis
8) Confidence 0.58 Published 1998 Journal Urology Section Title Doc Link 9609630 Disease Relevance 0.63 Pain Relevance 0.71
OBJECTIVES: To investigate the presence of mast cell growth factor receptors (c-kit) on bladder mast cells in interstitial cystitis (IC), a bladder condition occurring primarily in women.
Spec (investigate) Gene_expression (presence) of mast in bladder associated with interstitial cystitis
9) Confidence 0.58 Published 1998 Journal Urology Section Abstract Doc Link 9609630 Disease Relevance 0.59 Pain Relevance 0.67
MATERIALS AND METHODS: We devised a mouse model of allergen-induced allergic cystitis that is associated with the up-regulation of genes for interleukin-13, FcepsilonRIalpha and mast cells-derived proteases, a massive inflammatory reaction in the bladder tissue, and augmented levels of mast cell-derived protease 1 (MMCP1) detected in mouse sera.
Gene_expression (levels) of mast in mast cell
10) Confidence 0.58 Published 2006 Journal BJU Int. Section Body Doc Link 16469037 Disease Relevance 0.17 Pain Relevance 0

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