INT74154

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Context Info
Confidence 0.67
First Reported 1998
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 14
Total Number 15
Disease Relevance 10.33
Pain Relevance 6.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ifng) extracellular region (Ifng)
Anatomy Link Frequency
T cells 3
sciatic nerves 2
neurons 2
lymph nodes 1
coronary artery 1
Ifng (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cytokine 52 100.00 Very High Very High Very High
Peripheral nervous system 12 100.00 Very High Very High Very High
antagonist 1 100.00 Very High Very High Very High
Neuritis 45 99.66 Very High Very High Very High
Inflammation 24 98.80 Very High Very High Very High
Sciatic nerve 6 94.28 High High
Spinal cord 2 83.88 Quite High
Thalamus 1 83.08 Quite High
Hippocampus 1 82.28 Quite High
aspirin 3 76.72 Quite High
Disease Link Frequency Relevance Heat
Cancer 5 99.92 Very High Very High Very High
Necrosis 5 99.68 Very High Very High Very High
Experimental Autoimmune Neuritis 45 99.66 Very High Very High Very High
Coronary Artery Disease 16 99.44 Very High Very High Very High
Immunization 6 99.38 Very High Very High Very High
INFLAMMATION 18 98.80 Very High Very High Very High
Atherosclerosis 4 96.36 Very High Very High Very High
Disease 12 95.84 Very High Very High Very High
Multiple Sclerosis 8 95.52 Very High Very High Very High
Apoptosis 4 92.52 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In order to further analyze the role of these T cells and their corresponding cytokines in EAN, we studied the expression of mRNA for IFN-gamma, IL-4, and IL-10 in the cauda equina of rats with EAN using a quantitative competitive reverse transcriptase PCR method.
Transcription (expression) of IFN-gamma in T cells associated with neuritis and cytokine
1) Confidence 0.67 Published 1998 Journal J. Neuroimmunol. Section Abstract Doc Link 9628467 Disease Relevance 1.04 Pain Relevance 0.60
This study examined the time course of mRNA levels of the proinflammatory cytokines interferon-gamma (IFNgamma), interleukin-1beta (IL1beta), interleukin-12 (IL12; p40 subunit), and the immunosuppressant interleukin-10 (IL10) by semiquantitative reverse transcription polymerase chain reaction (RT-PCR) in rats with actively induced experimental autoimmune neuritis (EAN) and in distal stumps of crushed sciatic nerves undergoing Wallerian degeneration.
Transcription (levels) of IFNgamma in sciatic nerves associated with experimental autoimmune neuritis, wallerian degeneration, sciatic nerve, neuritis and cytokine
2) Confidence 0.55 Published 1998 Journal J. Neurosci. Res. Section Abstract Doc Link 9514202 Disease Relevance 0.56 Pain Relevance 0.49
This study examined the time course of mRNA levels of the proinflammatory cytokines interferon-gamma (IFNgamma), interleukin-1beta (IL1beta), interleukin-12 (IL12; p40 subunit), and the immunosuppressant interleukin-10 (IL10) by semiquantitative reverse transcription polymerase chain reaction (RT-PCR) in rats with actively induced experimental autoimmune neuritis (EAN) and in distal stumps of crushed sciatic nerves undergoing Wallerian degeneration.
Transcription (levels) of interferon-gamma in sciatic nerves associated with experimental autoimmune neuritis, wallerian degeneration, sciatic nerve, neuritis and cytokine
3) Confidence 0.55 Published 1998 Journal J. Neurosci. Res. Section Abstract Doc Link 9514202 Disease Relevance 0.55 Pain Relevance 0.48
This was accompanied by a significant reduction in mRNA levels for IFN-gamma and inducible nitric oxide synthase.
Transcription (levels) of IFN-gamma
4) Confidence 0.52 Published 2002 Journal Acta Neuropathol. Section Abstract Doc Link 11810178 Disease Relevance 0.64 Pain Relevance 0.20
Increased mRNA expression for IFN-gamma and TNF-alpha was registered correlating with the peak of clinical signs of EAN, and high levels of mRNA expression for IL-4, IL-10, and TGF-beta were associated with EAN recovery.
Transcription (expression) of IFN-gamma associated with neuritis
5) Confidence 0.41 Published 2004 Journal Exp. Neurol. Section Abstract Doc Link 15530887 Disease Relevance 1.08 Pain Relevance 1.02
High levels of tumor necrosis factor-alpha (TNF-alpha) and interferon-gamma (IFN-gamma) mRNAs were also detected, and both these cytokines can be harmful to several types of CNS cells, including neurons.
Transcription (detected) of interferon-gamma in neurons associated with necrosis, cancer and cytokine
6) Confidence 0.40 Published 2000 Journal J. Neurosci. Section Abstract Doc Link 10884312 Disease Relevance 0.73 Pain Relevance 0.13
High levels of tumor necrosis factor-alpha (TNF-alpha) and interferon-gamma (IFN-gamma) mRNAs were also detected, and both these cytokines can be harmful to several types of CNS cells, including neurons.
Transcription (detected) of IFN-gamma in neurons associated with necrosis, cancer and cytokine
7) Confidence 0.35 Published 2000 Journal J. Neurosci. Section Abstract Doc Link 10884312 Disease Relevance 0.72 Pain Relevance 0.13
P2 peptide induced suppression of EAN was associated with PNS antigen specific T cell hyporesponsiveness reflected by lymphocyte proliferation, numbers of PNS antigen-reactive IFN-gamma secreting and IFN-gamma mRNA expressing lymph node cells, but elevated levels of PNS antigen reactive TGF-beta mRNA secreting cells.
Transcription (numbers) of IFN-gamma in lymphocyte associated with peripheral nervous system and neuritis
8) Confidence 0.33 Published 1998 Journal J. Neuroimmunol. Section Abstract Doc Link 9630162 Disease Relevance 1.35 Pain Relevance 1.15
Restricted areas showed elevations in messenger RNA expression of interleukin-1 receptor antagonist, interleukin-6, inducible nitric oxide synthase, interferon-gamma, and inducible cyclooxygenase.
Transcription (expression) of interferon-gamma associated with antagonist
9) Confidence 0.27 Published 2000 Journal Neuroscience Section Abstract Doc Link 10683422 Disease Relevance 0.56 Pain Relevance 0.46
VPA (300 mg/kg, intraperitoneally) administration to EAN rats once daily immediately following immunization significantly suppressed mRNA levels of interferon-gamma, tumor necrosis factor-alpha, interleukin (IL)-1beta, IL-4, IL-6 and IL-17 in the lymph nodes of EAN rats.
Transcription (levels) of interferon-gamma in lymph nodes associated with necrosis, cancer, immunization and neuritis
10) Confidence 0.17 Published 2008 Journal Cell. Mol. Life Sci. Section Abstract Doc Link 18953683 Disease Relevance 1.34 Pain Relevance 0.98
Splenic T cells were isolated and the production and mRNA expression of interleukin (IL)-2, interferon-gamma, IL-4, and IL-10 were assayed.
Transcription (expression) of interferon-gamma in T cells
11) Confidence 0.15 Published 2009 Journal Anesth. Analg. Section Body Doc Link 19843806 Disease Relevance 0 Pain Relevance 0
Th1 cytokine (IL-2 and interferon-gamma) production and mRNA expression in splenic T cells of traumatized rats were significantly decreased on postoperative day 3 (P < 0.001, trauma group versus control group), whereas Th2 cytokine (IL-4 and IL-10) production and mRNA expression were increased (P < 0.001).
Transcription (expression) of interferon-gamma in T cells
12) Confidence 0.15 Published 2009 Journal Anesth. Analg. Section Body Doc Link 19843806 Disease Relevance 0 Pain Relevance 0
However, lidocaine inhibited, in a dose-dependent manner, the proliferative response and mRNA expression and protein production of IL-5 and IFN-gamma of PBMCs stimulated with D farinae, purified protein derivatives, or phorbol 12-myristate 13-acetate plus calcium ionophore.
Transcription (expression) of IFN-gamma
13) Confidence 0.03 Published 2002 Journal J. Allergy Clin. Immunol. Section Body Doc Link 11897996 Disease Relevance 0.05 Pain Relevance 0
Patients with CAD showed higher constitutive expression of CCL2, CXCL8, CXCL9, CXCL10 and IFN-gamma mRNA and, after stimulation with oxLDL, higher expression of CCL2 and CXCL8 mRNA than the control group.
Transcription (expression) of IFN-gamma associated with coronary artery disease
14) Confidence 0.01 Published 2009 Journal Int. J. Cardiol. Section Abstract Doc Link 18617279 Disease Relevance 0.96 Pain Relevance 0.30
We evaluated mRNA expression and protein production of CCL2, CXCL8, CXCL9, CXCL10, IFN-gamma and IL-10 in vitro as well as the expression of the CCR2 and CXCR3 receptors in peripheral blood mononuclear cells (PBMCs) of patients with coronary artery disease (CAD) and healthy controls in the presence or absence of oxidized LDL (oxLDL).
Transcription (expression) of IFN-gamma in coronary artery associated with coronary artery disease
15) Confidence 0.01 Published 2009 Journal Int. J. Cardiol. Section Abstract Doc Link 18617279 Disease Relevance 0.74 Pain Relevance 0.26

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