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Context Info
Confidence 0.48
First Reported 1998
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 16
Total Number 17
Disease Relevance 10.11
Pain Relevance 2.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Icam1) cell adhesion (Icam1) plasma membrane (Icam1)
Anatomy Link Frequency
leukocyte 3
macrophage 1
Plasma 1
bladder 1
endothelial cells 1
Icam1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 95 100.00 Very High Very High Very High
interstitial cystitis 8 97.32 Very High Very High Very High
Angina 6 97.12 Very High Very High Very High
Inflammation 259 96.72 Very High Very High Very High
ischemia 113 95.60 Very High Very High Very High
Inflammatory response 41 95.52 Very High Very High Very High
cytokine 101 90.88 High High
cva 39 85.00 Quite High
Infliximab 32 84.48 Quite High
Pain 2 84.48 Quite High
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 107 100.00 Very High Very High Very High
Adhesions 85 100.00 Very High Very High Very High
Atherosclerosis 29 100.00 Very High Very High Very High
Myocardial Infarction 19 99.28 Very High Very High Very High
Death 43 97.92 Very High Very High Very High
Brain Injury 85 97.52 Very High Very High Very High
Cardiovascular Disease 23 97.44 Very High Very High Very High
Interstitial Cystitis 8 97.32 Very High Very High Very High
Cv General 3 Under Development 6 97.12 Very High Very High Very High
INFLAMMATION 307 96.72 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
ICAM-1 expression was quantified using monoclonal antibodies against rat ICAM-1 that bind to the endothelium in proportion to the degree of adhesion molecule expression.
ICAM-1 Binding (bind) of in endothelium
1) Confidence 0.48 Published 1998 Journal J. Rheumatol. Section Body Doc Link 9517771 Disease Relevance 0.15 Pain Relevance 0
Thus the superficial gastric and duodenal mucosal microcirculations have a much lower density of ICAM-1 and P-selectin and less leukocyte-endothelial interactions than occurs in the deeper layers of the gut wall even during stimulated upregulation with endotoxin.
ICAM-1 Binding (interactions) of in leukocyte
2) Confidence 0.35 Published 2005 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 16020654 Disease Relevance 0.18 Pain Relevance 0
, and ICAM-1 in the surrounding
ICAM-1 Binding (surrounding) of
3) Confidence 0.34 Published 2008 Journal Mediators of Inflammation Section Body Doc Link PMC2375967 Disease Relevance 1.31 Pain Relevance 0.12
Plasma ICAM-1 was essentially associated with the risk of myocardial infarction or coronary death and also with angina pectoris.
ICAM-1 Binding (associated) of in Plasma associated with angina, death and myocardial infarction
4) Confidence 0.27 Published 2003 Journal Atherosclerosis Section Abstract Doc Link 12957696 Disease Relevance 0.73 Pain Relevance 0.18
OBJECTIVES: To study the presence of intercellular adhesion molecule-1 (ICAM-1), P-selectin, and E-selectin, as well as the cytoskeletal components talin and vinculin that bind to cellular adhesion molecules (CAMs), in bladder biopsies from patients with interstitial cystitis (IC) and controls.
ICAM-1 Binding (bind) of in bladder associated with interstitial cystitis and adhesions
5) Confidence 0.26 Published 2004 Journal Urology Section Abstract Doc Link 15072882 Disease Relevance 0.90 Pain Relevance 0.52
An increased number of activated mast cells associated with ICAM-1 was noted in IC.
ICAM-1 Binding (associated) of in mast cells
6) Confidence 0.25 Published 2004 Journal Urology Section Body Doc Link 15072882 Disease Relevance 0.13 Pain Relevance 0
NO modulates leukocyte adhesion in the microcirculation by decreasing the binding of PMN to the adhesion molecules E-selectin and ICAM-1 [22,24].
ICAM-1 Binding (binding) of in leukocyte associated with adhesions
7) Confidence 0.22 Published 2006 Journal BMC Nephrol Section Body Doc Link PMC1501003 Disease Relevance 1.05 Pain Relevance 0.34
The relative risk associated with the highest compared with the lowest thirds of ICAM-1 (>625 versus <502 ng/ml) was 2.45 (95% CI: 1.64-3.65, P<0.001) without adjustment; it decreased moderately (RR: 2.09; 95% CI: 1.34-3.24, P<0.001) after control for lipid and non-lipid factors and remained significantly elevated after adjustment for C-reactive protein (CRP) (RR: 1.90; 95% CI: 1.21-2.96, P=0.005).
ICAM-1 Binding (associated) of
8) Confidence 0.21 Published 2003 Journal Atherosclerosis Section Abstract Doc Link 12957696 Disease Relevance 0.66 Pain Relevance 0.12
To verify the binding specificity for ICAM-1, P-selectin, iNOS and IL-1?
ICAM-1 Binding (specificity) of
9) Confidence 0.20 Published 2010 Journal BMC Complement Altern Med Section Body Doc Link PMC3000377 Disease Relevance 0 Pain Relevance 0
To verify the binding specificity for ICAM-1, P-selectin, iNOS and IL-1?
ICAM-1 Binding (binding) of
10) Confidence 0.20 Published 2010 Journal BMC Complement Altern Med Section Body Doc Link PMC3000377 Disease Relevance 0 Pain Relevance 0
In contrast, 8 days following ligation, positive staining for ICAM-1 and P-selectin, were found in the gingivomucosal tissues from ligature operated rats (Figure 5c and 5e respectively), mainly localized in the inflammatory cells in derma and around the vessels respectively.
ICAM-1 Binding (ligation) of in vessels associated with inflammation
11) Confidence 0.20 Published 2010 Journal BMC Complement Altern Med Section Body Doc Link PMC3000377 Disease Relevance 0.44 Pain Relevance 0.25
Cardiovascular death/myocardial infarction was associated with elevated intercellular adhesion molecule-1 (354+/-142 vs 282+/-62ng x ml-1;P<0.01) and vascular adhesion molecule-1 (538+/-138 vs 433+/-135ng x ml-1;P =0.05), and E-selectin levels tended to be higher (72+/-54 vs 49+/-20ng x ml-1).
intercellular adhesion molecule-1 Binding (associated) of
12) Confidence 0.17 Published 1999 Journal Eur. Heart J. Section Body Doc Link 10381855 Disease Relevance 0.41 Pain Relevance 0
Intracellular adhesion molecule-1 (ICAM-1) is essential for the recruitment and trafficking of leukocytes through vessels and in T cell/macrophage interactions [36].
ICAM-1 Binding (interactions) of in T cell associated with adhesions
13) Confidence 0.14 Published 2010 Journal Journal of Neuroinflammation Section Body Doc Link PMC3022819 Disease Relevance 0.51 Pain Relevance 0.13
The interaction between leukocyte-function-associated antigen (LFA)-1 and ICAM-1 mediates adherence of leucocytes to endothelial cells, facilitating migration of inflammatory cells to inflamed areas [40].
ICAM-1 Binding (interaction) of in endothelial cells associated with inflammation
14) Confidence 0.10 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC464872 Disease Relevance 1.17 Pain Relevance 0.49
In addition, they are important mediators of induction of leukocyte chemotaxis in conjunction with adhesion molecules such as beta-4 integrin, intercellular adhesion molecule 1, and neutrophils.
intercellular adhesion molecule 1 Binding (beta-4 integrin) of in leukocyte associated with adhesions
15) Confidence 0.06 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2902015 Disease Relevance 0.67 Pain Relevance 0.12
Intracellular adhesion molecule-1 (ICAM-1) is essential for the recruitment and trafficking of leukocytes through vessels and in T cell/macrophage interactions [36].
ICAM-1 Binding (interactions) of in macrophage associated with adhesions
16) Confidence 0.05 Published 2010 Journal Journal of Neuroinflammation Section Body Doc Link PMC3022819 Disease Relevance 0.51 Pain Relevance 0.13
We and others have previously shown associations in patients with RA between atherosclerosis and sICAM-1, sE-selectin and PAI-1 [7,26,27] and between endothelial dysfunction and sVCAM-1 and sL-selectin [28].
sICAM-1 Binding (associations) of associated with atherosclerosis and rheumatoid arthritis
17) Confidence 0.03 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945061 Disease Relevance 1.31 Pain Relevance 0.30

General Comments

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