INT74326

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Context Info
Confidence 0.66
First Reported 1998
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 25
Total Number 25
Disease Relevance 9.70
Pain Relevance 7.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Crhr1) response to stress (Crhr1) signal transducer activity (Crhr1)
Anatomy Link Frequency
nucleus 4
colons 3
proximal 2
thalamus 2
visceral 1
Crhr1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
amygdala 70 100.00 Very High Very High Very High
antagonist 59 100.00 Very High Very High Very High
Enkephalin 16 100.00 Very High Very High Very High
Opioid 12 100.00 Very High Very High Very High
Intracerebroventricular 4 99.98 Very High Very High Very High
withdrawal 30 99.76 Very High Very High Very High
gABA 17 99.70 Very High Very High Very High
antidepressant 25 99.00 Very High Very High Very High
noradrenaline 9 98.02 Very High Very High Very High
Endogenous opioid 3 97.80 Very High Very High Very High
Disease Link Frequency Relevance Heat
Arthritis 23 100.00 Very High Very High Very High
Stress 145 99.82 Very High Very High Very High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

35 99.24 Very High Very High Very High
Sprains And Strains 9 99.16 Very High Very High Very High
Anxiety Disorder 42 98.54 Very High Very High Very High
Functional Bowel Disorder 11 94.80 High High
Neurodegenerative Disease 41 91.80 High High
Gastrointestinal Disease 3 90.28 High High
Pressure Volume 2 Under Development 3 88.40 High High
Body Weight 4 86.24 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A MEDLINE search of the years 1981 to 2005 was conducted using the key words stress, CRF, CRH, CRF1 receptor, IBS, CRD, female rat, visceral pain, estrogen, and anxiety.
Gene_expression (using) of CRF1 in visceral
1) Confidence 0.66 Published 2005 Journal Gender medicine : official journal of the Partnership for Gender-Specific Medicine at Columbia University Section Body Doc Link 16290887 Disease Relevance 0.08 Pain Relevance 0
Direct inhibitory effect of glucocorticoids on corticotrophin-releasing hormone gene expression in neurones of the paraventricular nucleus in rat hypothalamic organotypic cultures.
Gene_expression (expression) of corticotrophin-releasing hormone in nucleus
2) Confidence 0.65 Published 2008 Journal J. Neuroendocrinol. Section Title Doc Link 18624927 Disease Relevance 0.09 Pain Relevance 0.27
Anxiety-like behavior was measured in 5 groups of rats to determine the role of CRF1 receptors: arthritic rats without any additional intervention; arthritic rats that received systemic administration of vehicle (saline); arthritic rats with systemic administration of NBI27014 (5 mg/kg, i.p.); arthritic rats with vehicle (ACSF) administration into the CeA; and arthritic rats with intra-CeA administration of NBI27014 (100 ?
Gene_expression (administration) of CRF1 associated with anxiety disorder, amygdala and arthritis
3) Confidence 0.64 Published 2007 Journal Mol Pain Section Body Doc Link PMC1891279 Disease Relevance 0.94 Pain Relevance 0.42
Our preliminary evidence indicated a potentiating interaction between CRF-CRF1 pathways and estrogen in the stimulation of colonic motor responses that may take place within the enteric neurons of the colon, where both CRF1 and estrogen receptors are present.
Gene_expression (present) of CRF1 in neurons
4) Confidence 0.59 Published 2005 Journal Gender medicine : official journal of the Partnership for Gender-Specific Medicine at Columbia University Section Body Doc Link 16290887 Disease Relevance 0 Pain Relevance 0
Tyrosine hydroxylase-positive neurons expressing CRF1R were seen at the level of the nucleus tractus solitarius-A(2) cell group in both control and morphine-withdrawn rats.
Gene_expression (expressing) of CRF1R in nucleus associated with morphine
5) Confidence 0.58 Published 2010 Journal Mol. Pharmacol. Section Abstract Doc Link 20159948 Disease Relevance 0.53 Pain Relevance 1.24
Furthermore, an increased expression of CRF type 1 receptor (CRF-R1) was observed in the thalamus of NMS rats.
Gene_expression (expression) of CRF type 1 receptor in thalamus
6) Confidence 0.58 Published 2010 Journal Neuro Endocrinol. Lett. Section Body Doc Link 20424584 Disease Relevance 0.13 Pain Relevance 0
Furthermore, an increased expression of CRF type 1 receptor (CRF-R1) was observed in the thalamus of NMS rats.
Gene_expression (expression) of CRF-R1 in thalamus
7) Confidence 0.58 Published 2010 Journal Neuro Endocrinol. Lett. Section Body Doc Link 20424584 Disease Relevance 0.13 Pain Relevance 0
Neonatal maternal separation elevates thalamic corticotrophin releasing factor type 1 receptor expression response to colonic distension in rat.
Gene_expression (expression) of corticotrophin releasing factor type 1 receptor
8) Confidence 0.58 Published 2010 Journal Neuro Endocrinol. Lett. Section Title Doc Link 20424584 Disease Relevance 0.28 Pain Relevance 0.18
Exposure to open field (OF) and colorectal distension (CRD) stressors induced decreased protein expression of CRFR1 in SD proximal colons, an effect that was blunted in WKYs.
Gene_expression (expression) of CRFR1 in colons
9) Confidence 0.53 Published 2010 Journal Neurogastroenterol. Motil. Section Abstract Doc Link 19807869 Disease Relevance 0.56 Pain Relevance 0.06
Protein expression of functional CRFR1 was found to be comparable in control proximal and distal colon samples.
Gene_expression (expression) of CRFR1 in proximal
10) Confidence 0.53 Published 2010 Journal Neurogastroenterol. Motil. Section Abstract Doc Link 19807869 Disease Relevance 0.58 Pain Relevance 0.08
The effects of naloxone-precipitated morphine withdrawal on noradrenaline (NA) turnover in the paraventricular nucleus (PVN), HPA axis activity, signs of withdrawal, and c-Fos expression were measured in rats pretreated with vehicle, CP-154526 [N-butyl-N-ethyl-2,5-dimethyl-7-(2,4,6-trimethylphenyl)pyrrolo[3,2-e]pyrimidin-4-amine], or antalarmin (selective CRF1R antagonists).
Gene_expression (expression) of CRF1R in PVN associated with antagonist, noradrenaline, narcan, withdrawal and morphine
11) Confidence 0.51 Published 2010 Journal Mol. Pharmacol. Section Abstract Doc Link 20159948 Disease Relevance 0.56 Pain Relevance 1.26
Moreover, decreases in expression of CRFR1 in the proximal and distal colon of NS rats following exposure to CRD were blunted in MS rats.
Gene_expression (expression) of CRFR1 in proximal
12) Confidence 0.49 Published 2010 Journal Peptides Section Abstract Doc Link 20096320 Disease Relevance 0.23 Pain Relevance 0.07
Protein expression of CRFR1 and CRFR2 in the proximal colon was similar under baseline conditions and not affected by exposure to an OF stressor in either cohort.
Gene_expression (expression) of CRFR1 in colon
13) Confidence 0.49 Published 2010 Journal Peptides Section Abstract Doc Link 20096320 Disease Relevance 0.28 Pain Relevance 0.07
Coexpression of prodynorphin and corticotrophin-releasing hormone in the rat central amygdala: evidence of two distinct endogenous opioid systems in the lateral division.
Gene_expression (Coexpression) of corticotrophin-releasing hormone in amygdala associated with endogenous opioid, enkephalin and amygdala
14) Confidence 0.47 Published 2007 Journal J. Comp. Neurol. Section Title Doc Link 17722034 Disease Relevance 0 Pain Relevance 0.97
The lateral subdivision of the central nucleus of the amygdala (CeA) comprises two groups of gamma-aminobutyric acid (GABA) neurons that express corticotrophin-releasing hormone (CRH) and enkephalin.
Gene_expression (express) of corticotrophin-releasing hormone in lateral associated with gaba, enkephalin and amygdala
15) Confidence 0.47 Published 2007 Journal J. Comp. Neurol. Section Abstract Doc Link 17722034 Disease Relevance 0 Pain Relevance 0.75
Corticosterone can facilitate as well as inhibit corticotropin-releasing hormone gene expression in the rat hypothalamic paraventricular nucleus.
Gene_expression (expression) of inhibit corticotropin-releasing hormone gene in nucleus associated with enkephalin
16) Confidence 0.43 Published 1998 Journal Endocrinology Section Title Doc Link 9724036 Disease Relevance 0.16 Pain Relevance 0.10
In contrast, distal CRFR1 and CRFR2 levels were higher in MS rats but were significantly reduced post OF stress.
Gene_expression (levels) of CRFR1 associated with stress
17) Confidence 0.42 Published 2010 Journal Peptides Section Abstract Doc Link 20096320 Disease Relevance 0.29 Pain Relevance 0.07
Sham levels of CRFR1 were also similar in the proximal colon but significantly higher in WKY distal colons (SD: 0.38 +/- 0.14, WKY: 2.06 +/- 0.52, P < 0.01).
Gene_expression (levels) of CRFR1 in colons
18) Confidence 0.41 Published 2010 Journal Neurogastroenterol. Motil. Section Abstract Doc Link 19807869 Disease Relevance 0.57 Pain Relevance 0.08
Anti-beta-endorphin IgG down-regulated ET-A receptor protein expression in the caudate (51%), but had no effect on the expression of mu, delta, kappa opioid, ET-B, CRH-1 and CRH-2 receptors in any brain region.
Gene_expression (expression) of CRH-1 in brain associated with opioid
19) Confidence 0.34 Published 2006 Journal Peptides Section Abstract Doc Link 16165252 Disease Relevance 0 Pain Relevance 0.51
5% were selected for CRH, CRHBP, CRHR1, POMC, MC2R, NR3C1 and SERPINA6 and their 10 kb flanking regions using Tagger.24 SNPs were genotyped using Sequenom MassARRAY technology following the manufacturer's instructions (http://www.sequenom.com).
Gene_expression (selected) of CRHR1
20) Confidence 0.27 Published 2010 Journal Annals of the Rheumatic Diseases Section Body Doc Link PMC2927682 Disease Relevance 0.56 Pain Relevance 0.14

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