INT74394

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Context Info
Confidence 0.42
First Reported 1998
Last Reported 2009
Negated 1
Speculated 0
Reported most in Abstract
Documents 6
Total Number 7
Disease Relevance 1.96
Pain Relevance 5.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Gad2) lyase activity (Gad2) Golgi apparatus (Gad2)
cytoplasmic membrane-bounded vesicle (Gad2) plasma membrane (Gad2) cytoplasm (Gad2)
Anatomy Link Frequency
trigeminal ganglion 1
nucleus accumbens 1
peripheral nerve 1
caudate-putamen 1
globus pallidus 1
Gad2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
analgesia 28 100.00 Very High Very High Very High
trigeminal ganglion 68 99.96 Very High Very High Very High
fluoxetine 18 99.56 Very High Very High Very High
GABAergic 3 98.92 Very High Very High Very High
Nucleus accumbens 6 98.60 Very High Very High Very High
antagonist 27 98.12 Very High Very High Very High
qutenza 6 97.32 Very High Very High Very High
Dorsal horn 10 97.28 Very High Very High Very High
Pain 52 96.96 Very High Very High Very High
agonist 11 96.36 Very High Very High Very High
Disease Link Frequency Relevance Heat
Ganglion Cysts 92 99.96 Very High Very High Very High
Generalized Anxiety Disorder 40 97.32 Very High Very High Very High
Pain 52 96.96 Very High Very High Very High
Nervous System Injury 7 95.24 Very High Very High Very High
Repression 1 75.00 Quite High
Peripheral Arterial Disease 6 62.28 Quite High
Neuropathic Pain 17 48.64 Quite Low
Nociception 14 5.00 Very Low Very Low Very Low
Injury 6 5.00 Very Low Very Low Very Low
Inflammatory Pain 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It has recently been reported that there is selective depletion of GAD65, accompanied by a loss of GABAergic inhibition, in the ipsilateral dorsal horn in rats that have undergone peripheral nerve injuries [J Neurosci 22 (2002) 6724].
Negative_regulation (depletion) of GAD65 in peripheral nerve associated with nervous system injury, gabaergic and dorsal horn
1) Confidence 0.42 Published 2003 Journal Neuroscience Section Abstract Doc Link 12770560 Disease Relevance 0.49 Pain Relevance 0.35
GAD65-mediated analgesia is reversed by injection of bicuculline, a GABAA receptor antagonist
Negative_regulation (reversed) of GAD65-mediated associated with antagonist and analgesia
2) Confidence 0.41 Published 2009 Journal Mol Pain Section Body Doc Link PMC2734545 Disease Relevance 0.44 Pain Relevance 0.67
l) was injected into the trigeminal ganglion, GAD65-produced analgesia was reversed in the formalin test (Figure 5).
Negative_regulation (reversed) of GAD65-produced in trigeminal ganglion associated with ganglion cysts, trigeminal ganglion and analgesia
3) Confidence 0.41 Published 2009 Journal Mol Pain Section Body Doc Link PMC2734545 Disease Relevance 0.62 Pain Relevance 1.01
In addition, GAD65 mRNA levels were reduced in the globus pallidus.
Negative_regulation (reduced) of GAD65 mRNA in globus pallidus
4) Confidence 0.37 Published 1998 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9526047 Disease Relevance 0.08 Pain Relevance 0.82
In contrast, GAD65 mRNA levels remained low and were unaffected by the treatment, and EP10 was not detected.
Neg (unaffected) Negative_regulation (unaffected) of GAD65
5) Confidence 0.29 Published 1998 Journal Perspect Dev Neurobiol Section Abstract Doc Link 9777631 Disease Relevance 0.15 Pain Relevance 0.81
Fluoxetine (10 mg/kg) induced a reduction of preproenkephalin and GAD65 mRNA levels in the caudate-putamen and nucleus accumbens core and shell after 5 days of treatment.
Negative_regulation (reduction) of GAD65 mRNA in caudate-putamen associated with nucleus accumbens and fluoxetine
6) Confidence 0.27 Published 1998 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9526047 Disease Relevance 0.09 Pain Relevance 0.80
Fluoxetine (10 mg/kg) induced a reduction of preproenkephalin and GAD65 mRNA levels in the caudate-putamen and nucleus accumbens core and shell after 5 days of treatment.
Negative_regulation (reduction) of GAD65 mRNA in nucleus accumbens associated with nucleus accumbens and fluoxetine
7) Confidence 0.09 Published 1998 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9526047 Disease Relevance 0.09 Pain Relevance 0.80

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