INT74421

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Context Info
Confidence 0.06
First Reported 1998
Last Reported 1999
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.99
Pain Relevance 0.81

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
granulocyte 2
SPHAR (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 25 99.88 Very High Very High Very High
Inflammation 7 99.68 Very High Very High Very High
Inflammatory response 2 94.48 High High
Opioid 4 93.36 High High
Angina 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 10 99.68 Very High Very High Very High
Agranulocytosis 2 96.60 Very High Very High Very High
Necrosis 3 87.60 High High
Cancer 3 87.24 High High
Critical Illness 5 74.80 Quite High
Multiple Organ Failure 6 73.04 Quite High
Syndrome 2 72.64 Quite High
Acute Renal Failure 1 70.76 Quite High
Renal Failure 3 54.56 Quite High
Adhesions 21 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The proinflammatory cytokines are potent inducers of the hepatic acute-phase protein synthesis.
Positive_regulation (inducers) of Gene_expression (synthesis) of acute-phase protein associated with cytokine
1) Confidence 0.06 Published 1998 Journal Acta Anaesthesiol Scand Section Abstract Doc Link 9527747 Disease Relevance 0.35 Pain Relevance 0.66
It is well documented that different types of extracorporeal

circulation, such as haemodialysis using cuprophane membranes and cardiopulmonary bypass (CPB), are associated with complement activation [1,2]; granulocytopenia followed by granulocytosis [3], granulocyte activation and degranulation [3,4]; increased production of proinflammatory and anti-inflammatory cytokines; and increased acute-phase protein synthesis [5,6].

Positive_regulation (increased) of Gene_expression (synthesis) of acute-phase protein in granulocyte associated with agranulocytosis, inflammation and cytokine
2) Confidence 0.00 Published 1999 Journal Crit Care Section Body Doc Link PMC29032 Disease Relevance 0.64 Pain Relevance 0.15

General Comments

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