INT74425

Context Info Confidence 0.08 First Reported 1998 Last Reported 2010 Negated 0 Speculated 1 Reported most in Body Documents 8 Total Number 9 Disease Relevance 7.81 Pain Relevance 2.15

Anatomy Link Frequency hepatocytes 2 precursor cell 1 granulocyte 1 hip 1 neurons 1 SPHAR (Homo sapiens)

Pain Link Frequency Relevance Heat cytokine 39 99.60 Inflammation 53 99.40 rheumatoid arthritis 57 99.32 Osteoarthritis 29 98.84 Inflammatory response 5 94.48 anesthesia 2 94.48 Opioid 5 93.36 imagery 29 93.12 Angina 2 79.96 tolerance 1 59.12

Disease Link Frequency Relevance Heat Injury 12 99.64 INFLAMMATION 61 99.40 Rheumatoid Arthritis 57 99.32 Frailty 33 98.84 Delirium 43 98.38 Infection 11 98.20 Respiratory Syncytial Virus 25 97.04 Brain Injury 28 96.88 Cancer 8 96.52 Agranulocytosis 2 96.32

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The proinflammatory cytokines are potent inducers of the hepatic acute-phase protein synthesis.

Gene_expression (synthesis) of acute-phase protein associated with cytokine

1) Confidence 0.08 Published 1998 Journal Acta Anaesthesiol Scand Section Abstract Doc Link 9527747 Disease Relevance 0.35 Pain Relevance 0.66

A similar effect was observed for haptoglobin mRNA, used as a control for acute-phase protein expression.

Gene_expression (expression) of acute-phase protein

2) Confidence 0.05 Published 1999 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 10486281 Disease Relevance 0.16 Pain Relevance 0.13

Therefore, we aimed to determine whether PSP/reg is an acute-phase protein after nonpancreatic trauma.

Spec (whether) Gene_expression (/) of acute-phase protein in PSP associated with injury

3) Confidence 0.05 Published 2009 Journal Crit. Care Med. Section Abstract Doc Link 19325491 Disease Relevance 0.36 Pain Relevance 0.09

If the appearance of the S-phase cyclin, cyclin A, is used as a marker there is a significant cell cycle involvement of the neurons of the deep cerebellar nuclei in AD cases compared to controls.

Gene_expression (appearance) of S-phase cyclin in neurons associated with disease

4) Confidence 0.05 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC3018387 Disease Relevance 0.95 Pain Relevance 0

CRP is an acute-phase protein that is produced in large amounts by hepatocytes, upon stimulation by the cytokines interleukin (IL)6, tumor necrosis factor ?

Gene_expression (produced) of acute-phase protein in hepatocytes associated with necrosis, cancer and cytokine

5) Confidence 0.02 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2374464 Disease Relevance 1.57 Pain Relevance 0.59

Lending support to the hypothesis that acute inflammation leads to brain injury and subsequent development of delirium, a recent study found that delirium in postoperative hip-fractured patients was significantly associated with serum levels of C-reactive protein, an acute-phase protein that is a marker of acute inflammation [55].

Gene_expression (levels) of acute-phase protein in hip associated with inflammation, delirium and brain injury

6) Confidence 0.01 Published 2006 Journal Crit Care Section Body Doc Link PMC1794449 Disease Relevance 2.29 Pain Relevance 0.14

C-reactive protein (CRP) is an acute-phase protein that is predominantly synthesized by hepatocytes in response to inflammation, infection, and tissue damage [3, 4].

Gene_expression (synthesized) of acute-phase protein in hepatocytes associated with inflammation and infection

7) Confidence 0.01 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2686807 Disease Relevance 1.28 Pain Relevance 0.21

IL-6 is involved in hepatic acute-phase protein synthesis and stimulation of hematopoietic precursor cell proliferation and differentiation.

Gene_expression (synthesis) of acute-phase protein in precursor cell

8) Confidence 0.01 Published 2010 Journal Drug Design, Development and Therapy Section Body Doc Link PMC2990387 Disease Relevance 0.21 Pain Relevance 0.18

It is well documented that different types of extracorporeal circulation, such as haemodialysis using cuprophane membranes and cardiopulmonary bypass (CPB), are associated with complement activation [1,2]; granulocytopenia followed by granulocytosis [3], granulocyte activation and degranulation [3,4]; increased production of proinflammatory and anti-inflammatory cytokines; and increased acute-phase protein synthesis [5,6].

Gene_expression (synthesis) of acute-phase protein in granulocyte associated with agranulocytosis, inflammation and cytokine

9) Confidence 0.01 Published 1999 Journal Crit Care Section Body Doc Link PMC29032 Disease Relevance 0.63 Pain Relevance 0.15

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