INT74486

Context Info Confidence 0.67 First Reported 1998 Last Reported 2009 Negated 0 Speculated 0 Reported most in Title Documents 4 Total Number 4 Disease Relevance 1.00 Pain Relevance 2.20

plasma membrane (SCN1A) transmembrane transport (SCN1A)

Anatomy Link Frequency hippocampus 1 SCN1A (Homo sapiens)

Pain Link Frequency Relevance Heat sodium channel 16 100.00 Nav1.1 10 100.00 nav1.3 8 100.00 Hippocampus 6 99.68 tetrodotoxin 10 99.44 Nav1.2 5 98.16 Nav1.6 7 94.56 Nav1.7 7 93.20 nav1.8 9 74.56 Action potential 1 74.56

Disease Link Frequency Relevance Heat Epilepsy 4 98.52 Convulsion 4 94.48 Fever 1 93.60 Myoclonic Epilepsies 2 91.28 Generalized Epilepsy 1 87.80 Febrile Convulsions 1 86.76 Sperm Disorder 15 20.24 Pain 1 5.00 Nociception 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Voltage-gated sodium channel Nav1.1, Nav1.3 and beta1 subunit were up-regulated in the hippocampus of spontaneously epileptic rat.

Positive_regulation (up-regulated) of Nav1.1 in hippocampus associated with epilepsy, nav1.3, nav1.1, sodium channel and hippocampus

1) Confidence 0.67 Published 2008 Journal Brain Res. Bull. Section Title Doc Link 18158113 Disease Relevance 0.64 Pain Relevance 0.67

subunits are inhibited by TTX in the nanomolar range and include SCN1A (also known as Nav1.1), SCN2A (also known as Nav1.2), SCN3A (also known as Nav1.3), SCN4A (also known as Nav1.4), SCN8A (also known as Nav1.6), and SCN9A (also known as Nav1.7).

Positive_regulation (include) of SCN1A associated with nav1.3, tetrodotoxin, nav1.1, nav1.2, nav1.7 and nav1.6

2) Confidence 0.48 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2724540 Disease Relevance 0 Pain Relevance 1.26

Nonsense, frameshift, and missense mutations of SCN1A gene encoding the voltage-gated Na(+) channel alpha-subunit type I (Na(v)1.1) have been identified in patients with SMEI.

Positive_regulation (voltage-gated) of alpha-subunit type I

3) Confidence 0.44 Published 2003 Journal Epilepsy Res. Section Abstract Doc Link 12837571 Disease Relevance 0.35 Pain Relevance 0.07

A putative voltage-gated sodium channel alpha subunit (PpSCN1) from the hydrozoan jellyfish, Polyorchis penicillatus: structural comparisons and evolutionary considerations.

Positive_regulation (voltage-gated) of PpSCN1 associated with sodium channel

4) Confidence 0.02 Published 1998 Journal Biochem. Biophys. Res. Commun. Section Title Doc Link 9535741 Disease Relevance 0 Pain Relevance 0.19

General Comments

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