INT74864

Context Info Confidence 0.08 First Reported 1998 Last Reported 1998 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 0.34 Pain Relevance 0.44

nucleus (Chd7) helicase activity (Chd7) DNA binding (Chd7)

Anatomy Link Frequency liver 2 Chd7 (Mus musculus)

Pain Link Frequency Relevance Heat Paracetamol 12 98.86 dexamethasone 4 25.00

Disease Link Frequency Relevance Heat Toxicity 4 99.06 Hepatotoxicity 4 96.56

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The role of metallothionein (MT) in protecting the liver against paracetamol (PCT) toxicity was investigated in vivo and in vitro in mice lacking expression of MT-1 and MT-2 genes (MT -/-).

Negative_regulation (lacking) of Gene_expression (expression) of MT in liver associated with toxicity and paracetamol

1) Confidence 0.08 Published 1998 Journal Toxicology Section Abstract Doc Link 9570328 Disease Relevance 0.34 Pain Relevance 0.44

General Comments

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