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Context Info
Confidence 0.52
First Reported 1998
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 27
Total Number 28
Disease Relevance 26.19
Pain Relevance 15.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il13) extracellular region (Il13) cytoplasm (Il13)
Anatomy Link Frequency
lymphocyte 2
thymocyte 2
cartilage 1
fibroblast 1
eosinophil 1
Il13 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 357 100.00 Very High Very High Very High
cytokine 188 100.00 Very High Very High Very High
chemokine 24 100.00 Very High Very High Very High
Inflammatory mediators 22 100.00 Very High Very High Very High
headache 21 99.92 Very High Very High Very High
spastic colon 101 99.32 Very High Very High Very High
nud 15 99.12 Very High Very High Very High
Migraine 8 98.92 Very High Very High Very High
Hyperalgesia 12 98.84 Very High Very High Very High
Angina 7 98.84 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 413 100.00 Very High Very High Very High
Necrosis 23 100.00 Very High Very High Very High
Cancer 16 100.00 Very High Very High Very High
Headache 15 99.92 Very High Very High Very High
Hyperalgesia 20 99.80 Very High Very High Very High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

98 99.32 Very High Very High Very High
Dyspepsia 15 99.12 Very High Very High Very High
Injury 52 99.06 Very High Very High Very High
Migraine Disorders 8 98.92 Very High Very High Very High
Angina 6 98.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The effect of interleukin-13 (IL-13) on hyperalgesic responses to intraplantar (i.pl.) injection of carrageenin, E. coli endotoxin (LPS), bradykinin, tumour necrosis factor a (TNF-alpha), interleukin-1 beta (IL-1 beta), interleukin-8 (IL-8) and prostaglandin E(2) (PGE(2)) was investigated in a model of mechanical hyperalgesia in rats.
Gene_expression (effect) of IL-13 associated with necrosis, hyperalgesia, cancer and bradykinin
1) Confidence 0.52 Published 2001 Journal Eur. Cytokine Netw. Section Abstract Doc Link 11399514 Disease Relevance 0.53 Pain Relevance 0.32
The effect of interleukin-13 (IL-13) on hyperalgesic responses to intraplantar (i.pl.) injection of carrageenin, E. coli endotoxin (LPS), bradykinin, tumour necrosis factor a (TNF-alpha), interleukin-1 beta (IL-1 beta), interleukin-8 (IL-8) and prostaglandin E(2) (PGE(2)) was investigated in a model of mechanical hyperalgesia in rats.
Gene_expression (effect) of interleukin-13 associated with necrosis, hyperalgesia, cancer and bradykinin
2) Confidence 0.52 Published 2001 Journal Eur. Cytokine Netw. Section Abstract Doc Link 11399514 Disease Relevance 0.53 Pain Relevance 0.32
Also, the cellular source of the IL-13 was investigated.
Gene_expression (source) of IL-13
3) Confidence 0.46 Published 2001 Journal Eur. Cytokine Netw. Section Abstract Doc Link 11399514 Disease Relevance 0.59 Pain Relevance 0.41
The retrieved volume, which averaged 75–80% of the instilled PBS, was immediately centrifuged (500 g × 10 min at 4°C) and the supernatant was stored at -20°C until it was used for measurement of IL-4 and IL-13 levels.
Gene_expression (levels) of IL-13
4) Confidence 0.37 Published 2007 Journal J Inflamm (Lond) Section Body Doc Link PMC1876456 Disease Relevance 0.08 Pain Relevance 0
Assay of IL-4/IL-13 concentration in BALF
Gene_expression (concentration) of IL-13
5) Confidence 0.37 Published 2007 Journal J Inflamm (Lond) Section Body Doc Link PMC1876456 Disease Relevance 0.88 Pain Relevance 0.42
Levels of IL-4 and IL-13 in BALF
Gene_expression (Levels) of IL-13
6) Confidence 0.33 Published 2007 Journal J Inflamm (Lond) Section Body Doc Link PMC1876456 Disease Relevance 0.57 Pain Relevance 0.55
and IL2 and type 2 (Th2) produces IL4, IL5, IL9, IL10 and IL13.
Gene_expression (produces) of IL13
7) Confidence 0.25 Published 2008 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2637833 Disease Relevance 0.68 Pain Relevance 0.43
Also, several other pro-inflammatory (IL-2, IL-12, IL-17 and IL-18) and anti-inflammatory (IL-4 and IL-13) cytokines have been shown to be present in a lesser extent in IBS.62

2) Role of cytokines

Gene_expression (present) of IL-13 associated with inflammation, spastic colon and cytokine
8) Confidence 0.25 Published 2010 Journal Journal of Neurogastroenterology and Motility Section Body Doc Link PMC2978389 Disease Relevance 0.47 Pain Relevance 1.00
IMMC is an enriched source of inflammatory mediators such as histamine, prostaglandin D2, leukotriene, IL-3, IL-4, IL-5, IL-6, IL-8, IL-10, IL-13, IL-16, TNF-?
Gene_expression (source) of IL-13 associated with inflammatory mediators
9) Confidence 0.25 Published 2008 Journal BMC Gastroenterol Section Body Doc Link PMC2564972 Disease Relevance 1.65 Pain Relevance 0.52
The present study explored the possible relationships between immune cell subsets and interleukin (IL)-12 or IL-13 levels in the peritoneal fluid of patients with and without endometriosis.
Gene_expression (levels) of IL-13 in peritoneal fluid associated with endometriosis
10) Confidence 0.20 Published 2004 Journal Gynecol. Endocrinol. Section Abstract Doc Link 15255283 Disease Relevance 0.42 Pain Relevance 0.21
RESULTS: Before and after PCI, serum IL-4 levels were, respectively, 53.1+/-110.7 and 35.1+/-16.9 pg/ml (P not significant), and serum IL-13 levels 6.7+/-3.7 and 6.0+/-2.9 pg/ml (P<0.05).
Gene_expression (levels) of IL-13
11) Confidence 0.19 Published 2008 Journal Coron. Artery Dis. Section Body Doc Link 18418228 Disease Relevance 0.08 Pain Relevance 0
Connections were observed between peritoneal fluid interleukins and peritoneal fluid T cells: both patients with endometriosis and controls presented an inverse correlation between peritoneal fluid activated T cells and IL-13 levels, and a direct correlation between peritoneal fluid T cells and IL-12 concentrations.
Gene_expression (levels) of IL-13 in T cells associated with endometriosis
12) Confidence 0.17 Published 2004 Journal Gynecol. Endocrinol. Section Abstract Doc Link 15255283 Disease Relevance 0.61 Pain Relevance 0.35
IL-13 was detected in 17.1% of patients with migraine headaches and in 15.2% of patients with tension-type headaches.
Gene_expression (detected) of IL-13 associated with migraine and headache
13) Confidence 0.16 Published 2010 Journal Pharmacol Rep Section Abstract Doc Link 20508283 Disease Relevance 1.73 Pain Relevance 2.12
Only the IL-1-enhanced expression of the IL-13 receptor ?
Gene_expression (receptor) of IL-13
14) Confidence 0.09 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1794517 Disease Relevance 0.07 Pain Relevance 0.04
IL-13 overexpression during immune-complex-mediated arthritis significantly decreased chondrocyte death and MMP mediated cartilage destruction, despite the presence of enhanced inflammation [84].
Gene_expression (overexpression) of IL-13 in cartilage associated with inflammation, death and arthritis
15) Confidence 0.06 Published 2008 Journal Mod Rheumatol Section Body Doc Link PMC2275302 Disease Relevance 1.49 Pain Relevance 0.79
In parallel, antiinflammatory cytokines such as IL-4, IL-10, IL-13 and IL-1ra are produced and reduce hyperalgesic effects of the proinflammatory cytokines initially produced.
Gene_expression (produced) of IL-13 associated with hyperalgesia, inflammation and cytokine
16) Confidence 0.04 Published 2002 Journal Anaesthesist Section Abstract Doc Link 12125305 Disease Relevance 1.26 Pain Relevance 1.72
Compared to controls, stimulated lymphocyte expression of IL-5 and IL-13 was enhanced in IBS, FD and NCCP (all P < 0.05).
Gene_expression (expression) of IL-13 in lymphocyte associated with angina, spastic colon and nud
17) Confidence 0.04 Published 2009 Journal Neurogastroenterol. Motil. Section Abstract Doc Link 19126184 Disease Relevance 1.44 Pain Relevance 0.99
Natural extinguishing of acute-phase response occurs due to short half-lives of inflammatory mediators and production of anti-inflammatory cytokines such as IL-10, IL-4, IL-13, TGF-beta and some others. 3.
Gene_expression (production) of IL-13 associated with inflammatory mediators, inflammation and cytokine
18) Confidence 0.04 Published 1998 Journal Gen. Pharmacol. Section Abstract Doc Link 9595271 Disease Relevance 0.44 Pain Relevance 0.67
Lymphocytic [interleukin (IL)-5, IL-10, IL-13 and interferon gamma (IFN-gamma)] and monocytic [IL-10, IL-12, tumour necrosis factor (TNF)-alpha] cytokine production was characterized at baseline and after stimulation with phytohemagglutinine and anti-CD28 or lipopolysaccharide (LPS) in controls (n = 32), irritable bowel syndrome (IBS) (n = 30), functional dyspepsia (FD) (n = 23) and non-cardiac chest pain (NCCP) (n = 15).
Gene_expression (production) of IL-13 in bowel associated with necrosis, angina, cancer, spastic colon, nud and cytokine
19) Confidence 0.03 Published 2009 Journal Neurogastroenterol. Motil. Section Abstract Doc Link 19126184 Disease Relevance 1.17 Pain Relevance 0.70
PF cell populations were assessed by flow cytometry, and CF and PF levels of interleukin (IL)-6, IL-8, IL-13, IL-17 and CA-125 were quantified by ELISA.
Gene_expression (levels) of IL-13
20) Confidence 0.02 Published 2010 Journal J. Reprod. Immunol. Section Abstract Doc Link 20074813 Disease Relevance 1.43 Pain Relevance 0.38

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