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Context Info
Confidence 0.67
First Reported 1998
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 62
Total Number 62
Disease Relevance 43.45
Pain Relevance 15.02

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (TH1L) nucleus (TH1L)
Anatomy Link Frequency
Th2 cells 4
T lymphocyte 4
Th1 cells 3
plasma 2
blood 2
TH1L (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 1267 100.00 Very High Very High Very High
Inflammation 1078 100.00 Very High Very High Very High
chemokine 162 100.00 Very High Very High Very High
Inflammatory response 79 99.96 Very High Very High Very High
Crohn's disease 17 99.28 Very High Very High Very High
rheumatoid arthritis 958 99.14 Very High Very High Very High
Neuritis 7 98.68 Very High Very High Very High
Arthritis 305 97.76 Very High Very High Very High
Leflunomide 7 96.78 Very High Very High Very High
psoriasis 160 96.16 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 1169 100.00 Very High Very High Very High
Papillomavirus Infection 188 100.00 Very High Very High Very High
Cancer 158 99.74 Very High Very High Very High
Anaerobic Bacterial Infections 25 99.74 Very High Very High Very High
Recurrence 129 99.42 Very High Very High Very High
Sarcoidosis 61 99.40 Very High Very High Very High
Disease 687 99.28 Very High Very High Very High
Rheumatoid Arthritis 1117 99.14 Very High Very High Very High
Immunization 164 99.04 Very High Very High Very High
Asthma 708 99.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Here we summarise recent studies that have clearly documented that Th1/Th2/Th3 cytokines are differently upregulated during various clinical phases of EAN and GBS.
Positive_regulation (regulated d) of Th1 associated with neuritis and cytokine
1) Confidence 0.67 Published 1998 Journal J. Neuroimmunol. Section Abstract Doc Link 9600707 Disease Relevance 0.92 Pain Relevance 0.88
This finding likely has relevance for others using IFA adjuvants, as it reflects an unbalanced early Th2 dominance with the potential to compromise induction of Th1 and Tc1 responses.
Positive_regulation (induction) of Th1
2) Confidence 0.60 Published 2010 Journal J Transl Med Section Body Doc Link PMC2936306 Disease Relevance 0.23 Pain Relevance 0.03
In order to assess circulating Th1/Th2 and Tc1/Tc2 subsets, we used a whole-blood cytometric assay based on the intracellular interferon-gamma, interleukin 4 (IL-4), and IL-10 expression of the cells.
Positive_regulation (circulating) of Th1 in blood
3) Confidence 0.49 Published 2008 Journal J. Rheumatol. Section Body Doc Link 19004035 Disease Relevance 0.08 Pain Relevance 0
The early induction of Th2 cells in the vaccine microenvironment suggests that adjuvants that could increase Th1 cytokines may be valuable.
Positive_regulation (increase) of Th1 in Th2 cells associated with cytokine
4) Confidence 0.43 Published 2010 Journal J Transl Med Section Body Doc Link PMC2936306 Disease Relevance 0.30 Pain Relevance 0.13
Given the observed layer effect among compartments, the superficial papillary dermis may have less of a Th2 effect, suggestive of the possibility that this compartment may be a more receptive environment for inducing a Th1/Tc1 response.
Positive_regulation (inducing) of Th1 in dermis
5) Confidence 0.43 Published 2010 Journal J Transl Med Section Body Doc Link PMC2936306 Disease Relevance 0.13 Pain Relevance 0.06
Despite the induction of CD4+ and CD8+ T-cell responses in most patients when peptide vaccines are administered in incomplete Freund's adjuvant [19,49,50], the immunization site microenvironment may not be optimized for induction of Th1/Tc1 responses.
Positive_regulation (induction) of Th1 in T-cell associated with immunization
6) Confidence 0.40 Published 2010 Journal J Transl Med Section Body Doc Link PMC2936306 Disease Relevance 0.19 Pain Relevance 0.06
Over a similar time frame, cells accumulated that may have negative effects on induction of Th1/Tc1 responses at the vaccination site.
Positive_regulation (induction) of Th1
7) Confidence 0.40 Published 2010 Journal J Transl Med Section Body Doc Link PMC2936306 Disease Relevance 0.26 Pain Relevance 0.04
In prior trials, this tetanus peptide did induce Th1-dominant responses [30], and combinations with Class I MHC associated peptides induced antigen-specific cytotoxic T cells [15,18].
Positive_regulation (induce) of Th1 in cytotoxic T cells associated with anaerobic bacterial infections
8) Confidence 0.38 Published 2010 Journal J Transl Med Section Body Doc Link PMC2936306 Disease Relevance 0.28 Pain Relevance 0.04
We hypothesized that a vaccine in incomplete Freund's adjuvant (IFA) would increase dermal Th1 and Tc1-lymphocytes and mature DCs, but that repeated vaccination may increase regulatory cells.


Positive_regulation (increase) of Th1 in lymphocytes
9) Confidence 0.35 Published 2010 Journal J Transl Med Section Abstract Doc Link PMC2936306 Disease Relevance 0.17 Pain Relevance 0
mRNA, increased Th1 IFN-?
Positive_regulation (increased) of Th1
10) Confidence 0.32 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC2848054 Disease Relevance 0.52 Pain Relevance 0.27
Different patterns of cytokines are involved in the pathogenesis of these diseases and they may act in opposite ways, as observed, for instance in IBD, where Crohn's disease lesion is related to a predominant activation of Th1-lymphocytes, while lesion of ulcerative colitis is mainly driven by Th2 cytokines [6,7].
Positive_regulation (activation) of Th1 in lymphocytes associated with inflammatory bowel disease, crohn's disease, disease and cytokine
11) Confidence 0.32 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC2848054 Disease Relevance 1.17 Pain Relevance 0.39
Enhancement of the Th1 immune response is well recognized in both diseases.
Positive_regulation (Enhancement) of Th1 associated with disease
12) Confidence 0.32 Published 2006 Journal BMC Pulm Med Section Body Doc Link PMC1716762 Disease Relevance 2.04 Pain Relevance 0.42
TH17 cells appear to be an early, sequential response to pathogens prior to the induction of a TH1 or TH2 response (69).
Positive_regulation (induction) of TH1
13) Confidence 0.30 Published 2009 Journal Parasite Immunology Section Body Doc Link PMC2759986 Disease Relevance 0.61 Pain Relevance 0.35
It does so by binding to their shared p40 subunit, therefore blocking the interaction with their cognate receptors.41 This agent thus targets Th1 and Th17 arms of immunity, both of which we now know are key parts in the immunopathogenesis of psoriasis.
Positive_regulation (targets) of Th1 in arms associated with psoriasis
14) Confidence 0.30 Published 2010 Journal Core Evidence Section Body Doc Link PMC2915500 Disease Relevance 0.61 Pain Relevance 0.27
Single-cell analysis was performed to verify polarization of the RA CD4+ T cells after differentiation towards either a Th1 or a Th2 phenotype (Fig. 5a is representative of FACS analysis, and Fig. 5b shows the average percentages of Th1 and Th2 cells of seven RA patients).
Positive_regulation (representative) of Th1 in Th2 cells associated with rheumatoid arthritis
15) Confidence 0.29 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC193727 Disease Relevance 0.60 Pain Relevance 0.33
Single-cell analysis was performed to verify polarization of the RA CD4+ T cells after differentiation towards either a Th1 or a Th2 phenotype (Fig. 5a is representative of FACS analysis, and Fig. 5b shows the average percentages of Th1 and Th2 cells of seven RA patients).
Positive_regulation (percentages) of Th1 in Th2 cells associated with rheumatoid arthritis
16) Confidence 0.29 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC193727 Disease Relevance 0.58 Pain Relevance 0.32
We also found highly significant increases in Th1 and IL-17+IFN?
Positive_regulation (increases) of Th1
17) Confidence 0.28 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2931706 Disease Relevance 0.62 Pain Relevance 0.31
Accumulation of Th2 vs Th1 cells in blood may result from changes in T-cell migration.
Positive_regulation (Accumulation) of Th1 in blood
18) Confidence 0.27 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC400411 Disease Relevance 0.93 Pain Relevance 0.44
IL-12 is considered to play a critical role in inducing Th1-cell-mediated organ-specific autoimmune diseases, as shown in several animal models [25-28].
Positive_regulation (inducing) of Th1 associated with autoimmune disease
19) Confidence 0.27 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC400411 Disease Relevance 0.92 Pain Relevance 0.52
In order to assess overall differences in systemic response to the Th1-inducing cytokines, IL-12 and IL-18, we compared the IFN-?
Positive_regulation (response) of Th1 associated with cytokine
20) Confidence 0.27 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC400411 Disease Relevance 0.66 Pain Relevance 0.42

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