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Context Info
Confidence 0.75
First Reported 1998
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 41
Total Number 46
Disease Relevance 22.10
Pain Relevance 4.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Mapt) cytoskeleton (Mapt) nucleus (Mapt)
enzyme binding (Mapt) cytoplasm (Mapt)
Anatomy Link Frequency
medial cerebellar nucleus 4
brain 3
neurons 2
Purkinje cells 2
cleavage 1
Mapt (Mus musculus)
Pain Link Frequency Relevance Heat
Substantia nigra 107 99.92 Very High Very High Very High
Spinal cord 215 99.84 Very High Very High Very High
Central nervous system 267 99.16 Very High Very High Very High
anesthesia 13 97.40 Very High Very High Very High
isoflurane 5 96.96 Very High Very High Very High
trigeminal ganglion 66 96.60 Very High Very High Very High
Root ganglion neuron 1 94.56 High High
imagery 314 93.16 High High
medulla 44 93.08 High High
Kappa opioid receptor 21 91.96 High High
Disease Link Frequency Relevance Heat
Disease 986 100.00 Very High Very High Very High
Dementia 103 100.00 Very High Very High Very High
Aging 16 100.00 Very High Very High Very High
Targeted Disruption 1482 99.84 Very High Very High Very High
Ganglion Cysts 101 96.60 Very High Very High Very High
Dislocations 5 96.28 Very High Very High Very High
Frontotemporal Dementia 56 95.64 Very High Very High Very High
Amyloid Plaque 133 94.88 High High
Shock 8 91.56 High High
Apoptosis 34 91.00 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To this end, we have crossed our AID lines with hTau mice [29], [30] overexpressing human Tau.
Gene_expression (overexpressing) of Tau
1) Confidence 0.75 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2905372 Disease Relevance 1.21 Pain Relevance 0.04
Here, we have further characterized our AID transgenic mice to determine whether over-expression of AID in the forebrain, when human Tau is also expressed, provokes AD-like features, as recently suggested [22].
Gene_expression (expressed) of Tau in forebrain associated with targeted disruption and disease
2) Confidence 0.75 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2905372 Disease Relevance 1.26 Pain Relevance 0.04
Tau is synthesized within the neuron and localized in the axon where it promotes stability and assembly of microtubules [6].
Gene_expression (synthesized) of Tau in neuron
3) Confidence 0.75 Published 2010 Journal International Journal of Alzheimer's Disease Section Body Doc Link PMC2915796 Disease Relevance 1.35 Pain Relevance 0
A stable tetracycline-inducible human Tau (2N4R) expressing cell line was obtained from Dr.
Gene_expression (expressing) of Tau
4) Confidence 0.75 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2988785 Disease Relevance 0.06 Pain Relevance 0
The expressed PSA had no effect of the intracellular level of Tau under steady-state expression conditions (figure 6A) or when Tau expression was induced (figure 6B).
Gene_expression (expression) of Tau
5) Confidence 0.75 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2988785 Disease Relevance 0.08 Pain Relevance 0
HEK293 cells expressing a tetracycline-inducible human 2N4R Tau were grown in Dulbecco's modified Eagle's medium supplemented with 10% fetal bovine serum, 5 ?
Gene_expression (expressing) of Tau
6) Confidence 0.75 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2988785 Disease Relevance 0 Pain Relevance 0.09
One of the two brain hemispheres was processed for protein and Tau extraction, the other for immunohistochemistry.
Gene_expression (extraction) of Tau in brain
7) Confidence 0.65 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2905372 Disease Relevance 0.28 Pain Relevance 0.15
Tau is a microtubule-binding protein abundant in neurons and glia.
Gene_expression (abundant) of Tau in neurons
8) Confidence 0.65 Published 2006 Journal Orphanet J Rare Dis Section Body Doc Link PMC1563447 Disease Relevance 0.24 Pain Relevance 0.03
Recent reports suggest that the puromycin sensitive aminopeptidase (PSA, EC 3.4.11.14) may regulate Tau levels in vivo [11], and is able to hydrolyze Tau in vitro [12].
Gene_expression (levels) of Tau
9) Confidence 0.65 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2988785 Disease Relevance 0.32 Pain Relevance 0
This finding shows that Tau cleavage was internal, not expected for an aminopeptidase.
Gene_expression (cleavage) of Tau in internal
10) Confidence 0.65 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2988785 Disease Relevance 0 Pain Relevance 0
To determine whether PSA might facilitate cleavage of Tau in a cellular context, we transduced HEK 293 cells expressing a tetracycline-inducible human 2N4R Tau with a lentivirus expressing PSA.
Gene_expression (expressing) of Tau in cleavage
11) Confidence 0.58 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2988785 Disease Relevance 0.09 Pain Relevance 0
AID transgenic mice were crossed with hTau mice to yield mice expressing AID transgene, human Tau transgene and one allele copy of mouse Tau.


Gene_expression (expressing) of Tau associated with targeted disruption
12) Confidence 0.58 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2905372 Disease Relevance 0.49 Pain Relevance 0.03
As discussed above, AAV-mediated expression of truncated Tau, lacking the microtubule binding domain did not cause neurodegeneration, in marked contrast to full length protein Tau (Figures 3 and 4) and [30].
Gene_expression (expression) of Tau
13) Confidence 0.58 Published 2010 Journal International Journal of Alzheimer's Disease Section Body Doc Link PMC2938448 Disease Relevance 0.72 Pain Relevance 0.07
AID transgenic mice were crossed with hTau mice to yield mice expressing AID transgene, human Tau transgene and one allele copy of mouse Tau.


Gene_expression (expressing) of Tau associated with targeted disruption
14) Confidence 0.58 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2905372 Disease Relevance 0.49 Pain Relevance 0.03
In this context it is of interest that we observed altered levels of the microtubule-associated proteins MAP2 and tau in spinal cord neurons of different dt alleles.
Gene_expression (levels) of tau in spinal cord neurons associated with spinal cord
15) Confidence 0.58 Published 1998 Journal Mol. Cell. Neurosci. Section Abstract Doc Link 9604204 Disease Relevance 0.26 Pain Relevance 0.19
Additional AAV-vectors were constructed to express wild-type APP and wild-type Tau4R, in first instance as extra controls for the degeneration provoked by mutant Tau.P301L.
Gene_expression (express) of Tau4R
16) Confidence 0.48 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2748684 Disease Relevance 0.13 Pain Relevance 0
A final important point concerns the question why AAV-based models are more powerful in producing neuro-degeneration than transgenic models expressing the same wild-type Tau4R isoform [41] or Tau.P301L mutant [23] at similar near-physiological levels.
Gene_expression (expressing) of Tau4R associated with targeted disruption
17) Confidence 0.48 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2748684 Disease Relevance 1.12 Pain Relevance 0.03
ChIP assays of the promoter regions of three constitutively expressed genes, Gapdh, Mapt (tau), and Eno2 (neuron specific enolase), were used as positive controls, and the results were normalized to negative control assays from the promoter region of the Alb1 (albumin) gene, which is not expressed in the nervous system.
Gene_expression (expressed) of Mapt in nervous system
18) Confidence 0.47 Published 2007 Journal Neural Develop Section Body Doc Link PMC1796875 Disease Relevance 0.48 Pain Relevance 0.19
Moreover, the ability of increased p-tau assays to discriminate AD from normal aging and other dementia is more sensitive and specific than that of CSF concentrations of t-tau and A?
Gene_expression (concentrations) of p-tau associated with dementia, aging and disease
19) Confidence 0.19 Published 2010 Journal International Journal of Alzheimer's Disease Section Body Doc Link PMC2915796 Disease Relevance 1.52 Pain Relevance 0
Moreover, the ability of increased p-tau assays to discriminate AD from normal aging and other dementia is more sensitive and specific than that of CSF concentrations of t-tau and A?
Gene_expression (concentrations) of t-tau associated with dementia, aging and disease
20) Confidence 0.19 Published 2010 Journal International Journal of Alzheimer's Disease Section Body Doc Link PMC2915796 Disease Relevance 1.46 Pain Relevance 0

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