INT75712

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Context Info
Confidence 0.59
First Reported 1998
Last Reported 2001
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 1.89
Pain Relevance 0.77

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Itpr1) nuclear envelope (Itpr1) endoplasmic reticulum (Itpr1)
protein complex (Itpr1) transmembrane transport (Itpr1) cytoplasm (Itpr1)
Anatomy Link Frequency
afferent arteriole 1
glomerulus 1
Itpr1 (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 1 99.82 Very High Very High Very High
Inflammation 2 98.88 Very High Very High Very High
Pain 2 97.72 Very High Very High Very High
IPN 2 95.20 Very High Very High Very High
Hyperalgesia 1 81.48 Quite High
cINOD 3 65.92 Quite High
adenocard 2 64.12 Quite High
antagonist 2 60.32 Quite High
cOX1 1 39.64 Quite Low
Disease Link Frequency Relevance Heat
Injury 1 99.28 Very High Very High Very High
INFLAMMATION 4 98.88 Very High Very High Very High
Pain 1 97.72 Very High Very High Very High
Pressure And Volume Under Development 1 97.36 Very High Very High Very High
Inflammatory Pain 2 95.20 Very High Very High Very High
Targeted Disruption 4 94.04 High High
Hypertension 2 89.92 High High
Hyperalgesia 1 81.48 Quite High
Nociception 2 79.28 Quite High
Diuresis 2 76.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
PGI2, the primary endogenous agonist for the IP receptor, is rapidly produced following tissue injury or inflammation; thus, it may be of equal, or greater, importance than PGE2 during episodes of inflammatory pain.
Gene_expression (produced) of IP receptor associated with inflammation, ipn, injury and agonist
1) Confidence 0.59 Published 1998 Journal Trends Pharmacol. Sci. Section Abstract Doc Link 9612089 Disease Relevance 0.90 Pain Relevance 0.49
The IP receptor messenger RNA is most highly expressed in the afferent arteriole and it may also modulate renal arterial resistance and renin release.
Gene_expression (expressed) of IP receptor in afferent arteriole
2) Confidence 0.14 Published 2000 Journal Curr. Opin. Nephrol. Hypertens. Section Abstract Doc Link 10654821 Disease Relevance 0.53 Pain Relevance 0.16
The IP receptor mRNA is highly expressed near the glomerulus, in the afferent arteriole, where it may also dilate renal arterioles and stimulate renin release.
Gene_expression (expressed) of IP receptor mRNA in glomerulus
3) Confidence 0.11 Published 2001 Journal Annu. Rev. Physiol. Section Abstract Doc Link 11181968 Disease Relevance 0.45 Pain Relevance 0.12

General Comments

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