INT75920

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Context Info
Confidence 0.03
First Reported 1998
Last Reported 1998
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0.85
Pain Relevance 0.89

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Slc8a1, Cpox) oxidoreductase activity (Cpox) plasma membrane (Slc8a1)
cytoplasm (Cpox) transmembrane transport (Slc8a1) response to stress (Slc8a1)
Slc8a1 (Rattus norvegicus)
Cpox (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Analgesic 4 99.12 Very High Very High Very High
aspirin 24 99.10 Very High Very High Very High
COX2 2 25.00 Low Low
cOX1 2 25.00 Low Low
Disease Link Frequency Relevance Heat
Adenocarcinoma 4 98.02 Very High Very High Very High
Aberrant Crypt Foci 6 92.72 High High
Colon Cancer 4 91.64 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Despite not inhibiting COX, NCX-4016 exhibited comparable analgesic activity to aspirin.
NCX-4016 Negative_regulation (inhibiting) of COX associated with aspirin and analgesic
1) Confidence 0.03 Published 1998 Journal Life Sci. Section Abstract Doc Link 9627095 Disease Relevance 0.46 Pain Relevance 0.59
Using a rat model of colonic adenocarcinoma, we compared the chemopreventative effects of aspirin versus a nitric oxide-releasing derivative (NCX-4016) which does not inhibit COX.
NCX-4016 Negative_regulation (inhibit) of COX associated with adenocarcinoma and aspirin
2) Confidence 0.03 Published 1998 Journal Life Sci. Section Abstract Doc Link 9627095 Disease Relevance 0.39 Pain Relevance 0.29

General Comments

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