INT75954

Context Info Confidence 0.09 First Reported 1998 Last Reported 1998 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 1.28 Pain Relevance 0.34

plasma membrane (Frk, Ptafr) nucleus (Frk, Ptafr) signal transduction (Ptafr) kinase activity (Frk) signal transducer activity (Ptafr) cytoplasm (Frk)

Anatomy Link Frequency brain 2 Frk (Mus musculus) Ptafr (Mus musculus)

Pain Link Frequency Relevance Heat Somatostatin 1 100.00 Enkephalin 1 100.00 substance P 1 100.00 Glutamate receptor 1 92.88 antagonist 1 91.36 cytokine 1 90.32

Disease Link Frequency Relevance Heat Congenital Anomalies 1 99.58 Infection 3 98.16 Cognitive Disorder 2 97.48 Gliosis 1 94.44 Encephalopathy 2 86.08 Syndrome 1 84.80 Leukemia 1 82.76 Murine Acquired Immunodeficiency Syndrome 1 75.00 Paralysis 1 69.04 Ataxia 1 67.04

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The neurochemical abnormalities include significant decreases in striatal Met-enkephalin and substance P (but not somatostatin), increases in concentrations of quinolinic acid and platelet-activating factor, and alterations in brain fyn kinase.

Negative_regulation (decreases) of fyn kinase Binding (alterations) of platelet-activating factor in brain associated with congenital anomalies, somatostatin, enkephalin and substance p

1) Confidence 0.09 Published 1998 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 9629308 Disease Relevance 1.28 Pain Relevance 0.34

General Comments

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