INT76015

Context Info Confidence 0.14 First Reported 1998 Last Reported 2003 Negated 0 Speculated 0 Reported most in Abstract Documents 3 Total Number 3 Disease Relevance 1.04 Pain Relevance 0.77

plasma membrane (DCSTAMP)

DCSTAMP (Homo sapiens)

Pain Link Frequency Relevance Heat dexamethasone 1 90.56 cytokine 10 89.68 tetrodotoxin 2 87.40 cINOD 6 81.92 Inflammation 2 78.40 COX-2 inhibitor 1 58.60 COX2 1 25.00

Disease Link Frequency Relevance Heat Necrosis 2 98.98 Cancer 2 98.80 Diarrhoea 4 80.72 Infection 2 79.92 Acquired Immune Deficiency Syndrome Or Hiv Infection 4 79.52 Inflammatory Bowel Disease 6 79.16 INFLAMMATION 2 75.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Unlike IL-1beta, NS-398 and Cig did not cause NF-kappaB (p65) nuclear translocation, nor did they further enhance IL-1beta-induced NF-kappaB translocation, but they stimulated PPARgamma translocation.

Localization (translocation) of IL-1beta-induced

1) Confidence 0.14 Published 2003 Journal J. Immunol. Section Abstract Doc Link 12517972 Disease Relevance 0.07 Pain Relevance 0.36

An ISC maximum of 2.5+/-0.3 micromol. h-1.cm-2 was reached at 20 ng/ml within 43+/-4 min. 22Na+ and 36Cl- fluxes were not altered and residual flux increased by 2.4+/-1.0 micromol.h-1.cm-2 indicating that the IL-1beta-induced ISC is based on electrogenic bicarbonate secretion.

Localization (secretion) of IL-1beta-induced

2) Confidence 0.13 Published 1998 Journal Cytokine Section Abstract Doc Link 9632533 Disease Relevance 0.51 Pain Relevance 0.20

At half maximum effective concentrations an additive action of tumour necrosis factor alpha (TNF-alpha) could be demonstrated on IL-1beta-induced secretion.

Localization (secretion) of IL-1beta-induced associated with necrosis and cancer

3) Confidence 0.13 Published 1998 Journal Cytokine Section Abstract Doc Link 9632533 Disease Relevance 0.46 Pain Relevance 0.21

General Comments

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