INT76092

From wiki-pain
Revision as of 10:26, 21 September 2012 by Daniel (Talk | contribs)

(diff) ← Older revision | Latest revision (diff) | Newer revision → (diff)
Jump to: navigation, search
Context Info
Confidence 0.66
First Reported 1998
Last Reported 2011
Negated 2
Speculated 0
Reported most in Body
Documents 10
Total Number 10
Disease Relevance 7.72
Pain Relevance 3.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

isomerase activity (ISYNA1) cytoplasm (ISYNA1)
Anatomy Link Frequency
macrophage 1
Leucocytes 1
endothelial cells 1
odontoblasts 1
medial longitudinal fasciculus 1
ISYNA1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Opioid 114 100.00 Very High Very High Very High
midbrain 5 99.76 Very High Very High Very High
pulpitis 4 99.60 Very High Very High Very High
Inflammation 124 97.76 Very High Very High Very High
Neurotransmitter 2 97.64 Very High Very High Very High
Multiple sclerosis 81 97.36 Very High Very High Very High
imagery 33 91.84 High High
Inflammatory response 13 90.36 High High
alcohol 6 90.16 High High
gABA 29 85.04 High High
Disease Link Frequency Relevance Heat
Ophthalmoplegia 23 100.00 Very High Very High Very High
Pulpitis 4 99.60 Very High Very High Very High
Injury 105 99.36 Very High Very High Very High
Polyps 29 98.66 Very High Very High Very High
Cancer 33 98.54 Very High Very High Very High
Hepatitis C Virus Infection 27 97.96 Very High Very High Very High
INFLAMMATION 131 97.76 Very High Very High Very High
Stress 200 97.62 Very High Very High Very High
Demyelinating Disease 107 97.52 Very High Very High Very High
Ileus 4 95.00 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We have localized the eNOS and iNOS by immunohistochemistry and have tested their mRNA expression by RT-PCR and protein levels by Western blots. eNOS is present in the endothelial cells and odontoblasts of the healthy pulp, but an elevation of eNOS mRNA and protein levels with a concomitant dilation of vessels was characteristic under pathological conditions.
Localization (localized) of iNOS in endothelial cells
1) Confidence 0.66 Published 2004 Journal J. Dent. Res. Section Abstract Doc Link 15044505 Disease Relevance 0.26 Pain Relevance 0.22
Additionally, constitutive NO release is being associated with positive biomedical phenomena, whereas inducible NO synthase (iNOS)-associated NO release with detrimental consequences in regard to endothelial inflammatory activities.
Neg (NO) Localization (release) of iNOS associated with inflammation
2) Confidence 0.55 Published 1998 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 9641464 Disease Relevance 0.19 Pain Relevance 0.26
Leucocytes produce the main inhibitory neurotransmitter of the gastrointestinal tract, nitric oxide, through the activity of the inducible isoform of nitric oxide synthase (iNOS).15 Opioids potentate iNOS induction and nitric oxide release from phagocytes;16 therefore, blockage of this opioid-mediated response might be of specific use in reversing postoperative ileus.11 Opioid-induced bowel dysfunction can lead to various gastrointestinal complications ranging from mild discomfort to fecal impaction, pseudo-obstruction, and bowel perforation.17,18 A recent survey suggests that severe opioid bowel dysfunction reduces the value of pain relief by more than 30%.
Localization (release) of iNOS in Leucocytes associated with pain, ileus, neurotransmitter, constipation and opioid
3) Confidence 0.27 Published 2010 Journal Core evidence Section Body Doc Link PMC2899781 Disease Relevance 0.62 Pain Relevance 1.43
INO, characterized by limited or slow adduction of the ipsilateral eye on horizontal saccadic eye movements and usually accompanied by horizontal nystagmus in the contralateral eye, INO is commonly associated with MS, and when seen in young undiagnosed patients, an INO should prompt a workup for demyelinating disease.102,105–107 Lesions of the medial longitudinal fasciculus (MLF), located in the dorsomedial pontine or midbrain tegmentum, cause INO.
Localization (cause) of INO in medial longitudinal fasciculus associated with nystagmus, multiple sclerosis, ophthalmoplegia, midbrain and demyelinating disease
4) Confidence 0.27 Published 2010 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC3000766 Disease Relevance 2.32 Pain Relevance 0.35
Within our cancer polyp group, the macrophage population appears to change with a reduced proportion of iNOS expressing classically activated cells.
Localization (proportion) of iNOS in macrophage associated with cancer and polyps
5) Confidence 0.25 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3017541 Disease Relevance 1.17 Pain Relevance 0.19
We have localized the eNOS and iNOS by immunohistochemistry and have tested their mRNA expression by RT-PCR and protein levels by Western blots. eNOS is present in the endothelial cells and odontoblasts of the healthy pulp, but an elevation of eNOS mRNA and protein levels with a concomitant dilation of vessels was characteristic under pathological conditions.
Localization (localized) of iNOS in odontoblasts
6) Confidence 0.22 Published 2004 Journal J. Dent. Res. Section Abstract Doc Link 15044505 Disease Relevance 0.26 Pain Relevance 0.22
The iNOS releases NO in large quantities (micromolar range)
Neg (NO) Localization (releases) of iNOS
7) Confidence 0.19 Published 2004 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC555773 Disease Relevance 0.18 Pain Relevance 0.16
First, only some HCV-related proteins, such as NS5A, NS3 and HCV core protein, are likely to play roles in mediating redox perturbations, which can include increased generation of both ROS and RNS, iNOS and COX-2 (NS5A and C).
Localization (generation) of iNOS associated with hepatitis c virus infection
8) Confidence 0.14 Published 2008 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2584013 Disease Relevance 1.29 Pain Relevance 0.07
In conclusion, animal studies employing TDS stress provide evidence that NO has a definite role in the pathophysiology of repeated trauma, particularly the induction of iNOS and the protracted release of cell-toxic amounts of NO.
Localization (release) of iNOS associated with stress and injury
9) Confidence 0.13 Published 2005 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2413191 Disease Relevance 1.11 Pain Relevance 0.20
It can be speculated that these secondary deteriorations were now due to the up-regulation of iNOS and excessively produced NO, which increased pulmonary shunting phenomena thereby further impairing pulmonary oxygenation.
Localization (regulation) of iNOS
10) Confidence 0.06 Published 2010 Journal Crit Care Section Body Doc Link PMC2945093 Disease Relevance 0.32 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox