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Context Info
Confidence 0.26
First Reported 1992
Last Reported 2009
Negated 1
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 5.35
Pain Relevance 0.88

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (TPO) oxidoreductase activity (TPO) plasma membrane (TPO)
cellular nitrogen compound metabolic process (TPO) cytoplasm (TPO)
Anatomy Link Frequency
medulla 1
upper 1
TPO (Homo sapiens)
Pain Link Frequency Relevance Heat
Clonidine 10 100.00 Very High Very High Very High
medulla 1 92.28 High High
anesthesia 1 85.24 High High
Disease Link Frequency Relevance Heat
Multiple System Atrophy 31 100.00 Very High Very High Very High
Autonomic Nervous System Disease 8 100.00 Very High Very High Very High
Sleep Apnea Syndromes 2 100.00 Very High Very High Very High
Disease 6 99.06 Very High Very High Very High
Airway Obstruction 2 97.90 Very High Very High Very High
Sudden Death 4 96.16 Very High Very High Very High
Pressure Volume 2 Under Development 2 95.76 Very High Very High Very High
Death 1 92.64 High High
Pathologic Constriction 1 91.76 High High
Paralysis 9 90.56 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We must be cautious not to exacerbate upper airway obstruction by continuous positive airway pressure (CPAP), which is now increasingly used to treat sleep disordered breathing of MSA.
Localization (breathing) of MSA in upper associated with airway obstruction, multiple system atrophy and sleep apnea syndromes
1) Confidence 0.26 Published 2009 Journal Rinsho Shinkeigaku Section Abstract Doc Link 19594101 Disease Relevance 1.48 Pain Relevance 0.09
We have investigated the growth hormone (GH) releasing effects of clonidine in patients with PAF and MSA to see whether this hormonal response could serve as a neuroendocrine marker to distinguish between the groups.
Localization (releasing) of MSA associated with autonomic nervous system disease, multiple system atrophy and clonidine
2) Confidence 0.15 Published 1992 Journal Lancet Section Abstract Doc Link 1353191 Disease Relevance 1.31 Pain Relevance 0.31
Clonidine has been proposed to differentiate multiple system atrophy (MSA) from idiopathic Parkinson's disease (IPD), as it does not increase growth hormone (GH) release in MSA.
Neg (not) Localization (release) of MSA associated with disease, multiple system atrophy and clonidine
3) Confidence 0.03 Published 2001 Journal Neurol. Sci. Section Abstract Doc Link 11487211 Disease Relevance 1.19 Pain Relevance 0.34
Although screening cardiovascular autonomic function tests did not conclusively indicate a diagnosis of MSA, vasopressin release in response to head-up tilt and growth hormone response to clonidine administration demonstrated inappropriate responses, suggesting that the noradrenergic neurons of the caudal ventrolateral medulla were impaired.
Localization (release) of MSA in medulla associated with medulla, multiple system atrophy and clonidine
4) Confidence 0.02 Published 2007 Journal Clin Neurol Neurosurg Section Abstract Doc Link 17826894 Disease Relevance 1.37 Pain Relevance 0.14

General Comments

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