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Context Info
Confidence 0.64
First Reported 1998
Last Reported 2010
Negated 4
Speculated 1
Reported most in Body
Documents 30
Total Number 33
Disease Relevance 20.74
Pain Relevance 5.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (CD38) hydrolase activity, acting on glycosyl bonds (CD38) plasma membrane (CD38)
nucleus (CD38)
Anatomy Link Frequency
T cells 5
smooth muscle 2
blood 2
B-cells 2
stem 2
CD38 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 123 99.70 Very High Very High Very High
Inflammation 241 99.50 Very High Very High Very High
metalloproteinase 8 99.00 Very High Very High Very High
dexamethasone 11 98.36 Very High Very High Very High
Leflunomide 163 97.62 Very High Very High Very High
agonist 66 97.36 Very High Very High Very High
adenocard 7 97.22 Very High Very High Very High
Etanercept 140 96.16 Very High Very High Very High
rheumatoid arthritis 51 95.92 Very High Very High Very High
Opioid 2 95.84 Very High Very High Very High
Disease Link Frequency Relevance Heat
Diffuse Large B-cell Lymphoma 116 99.98 Very High Very High Very High
Follicular Lymphoma 47 99.98 Very High Very High Very High
Adhesions 16 99.76 Very High Very High Very High
B-cell Lymphoma 54 99.70 Very High Very High Very High
INFLAMMATION 254 99.50 Very High Very High Very High
Infection 282 99.28 Very High Very High Very High
Overactive Bladder 2 98.84 Very High Very High Very High
Fever 4 98.80 Very High Very High Very High
Rheumatoid Arthritis 61 98.20 Very High Very High Very High
Apoptosis 98 97.88 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We found that human myometrium contains all the components of the cADPR pathway including (1) cADPR-activated microsomal Ca(2+) release and (2) enzymes responsible for synthesis and degradation of cADPR and, furthermore, that intracellular levels of cADPR were detected in human myometrial tissue.
Gene_expression (synthesis) of cADPR in myometrium
1) Confidence 0.64 Published 2002 Journal Arch. Biochem. Biophys. Section Abstract Doc Link 12413485 Disease Relevance 0.06 Pain Relevance 0.06
As shown by 2-color immunofluorescence, the protein expression of these receptors was higher in the more immature CD38(dim) than in the CD38(bright) subset within the CD34(+) population, and completely absent in fully differentiated blood cells, suggesting that those receptors play a role in developmentally early CD34(+) stem and progenitor cells.
Neg (absent) Gene_expression (expression) of CD38 in stem
2) Confidence 0.58 Published 2004 Journal Blood Section Abstract Doc Link 15016651 Disease Relevance 0 Pain Relevance 0.18
The DLBCL expressed CD19, CD20, CD79a, CD5, CD10, CD23, CD38, CD117, bcl-2, and bcl-6, with monotypic expression of immunoglobulin kappa light chain.
Gene_expression (expressed) of CD38 associated with diffuse large b-cell lymphoma
3) Confidence 0.53 Published 2005 Journal Am. J. Clin. Pathol. Section Abstract Doc Link 15842045 Disease Relevance 0.76 Pain Relevance 0.11
As shown by 2-color immunofluorescence, the protein expression of these receptors was higher in the more immature CD38(dim) than in the CD38(bright) subset within the CD34(+) population, and completely absent in fully differentiated blood cells, suggesting that those receptors play a role in developmentally early CD34(+) stem and progenitor cells.
Neg (absent) Gene_expression (expression) of CD38 in stem
4) Confidence 0.51 Published 2004 Journal Blood Section Abstract Doc Link 15016651 Disease Relevance 0 Pain Relevance 0.18
At flow cytometry, these cells were positive for CD38, CD138, and negative for CD56 and CD20.
Neg (negative) Gene_expression (positive) of CD38
5) Confidence 0.50 Published 2010 Journal J Hematol Oncol Section Body Doc Link PMC2944146 Disease Relevance 0.56 Pain Relevance 0.10
HL-60 cells normally do not express the cell surface antigen CD38, but when exposed to ATRA, these cells undergo an immunophenotypic transition to become CD38+ [20].
Neg (not) Gene_expression (express) of CD38 in HL-60
6) Confidence 0.49 Published 2009 Journal PLoS Computational Biology Section Body Doc Link PMC2791157 Disease Relevance 0.28 Pain Relevance 0
The DLBCL expressed CD19, CD20, CD79a, CD5, CD10, CD23, CD38, CD117, bcl-2, and bcl-6, with monotypic expression of immunoglobulin kappa light chain.
Gene_expression (expression) of CD38 associated with diffuse large b-cell lymphoma
7) Confidence 0.46 Published 2005 Journal Am. J. Clin. Pathol. Section Abstract Doc Link 15842045 Disease Relevance 0.75 Pain Relevance 0.11
Other cell subpopulations, such as CD34+/CD117+, CD34+/CXCR4+, CD34+/CD38+ and CD34+/CD45+ broadly follow the same pattern as that of EPCs [45,46].
Gene_expression (/) of CD38
8) Confidence 0.37 Published 2010 Journal J Angiogenes Res Section Body Doc Link PMC2834645 Disease Relevance 0.79 Pain Relevance 0.19
Other cell subpopulations, such as CD34+/CD117+, CD34+/CXCR4+, CD34+/CD38+ and CD34+/CD45+ broadly follow the same pattern as that of EPCs [45,46].
Gene_expression (/) of CD38
9) Confidence 0.37 Published 2010 Journal J Angiogenes Res Section Body Doc Link PMC2834645 Disease Relevance 0.80 Pain Relevance 0.19
It is generally accepted that the most primitive and long-term human HSCs are characterized by the expression of CD133, Thy1 (CD90) and VEGFR2 and by a variable expression of CD34 and CD38 [68].
Gene_expression (expression) of CD38
10) Confidence 0.32 Published 2010 Journal Stem Cells International Section Body Doc Link PMC2963137 Disease Relevance 0.24 Pain Relevance 0.07
CD69 and CD38 expression was high and similar between groups, consistent with immune activation.
Gene_expression (expression) of CD38
11) Confidence 0.32 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2943484 Disease Relevance 0.65 Pain Relevance 0.03
A population of GC B-cells of variable size has been characterized in human lymphoid organs by the co-expression of CD20 antigen with CD10, CD38 and CD77 antigens.
Gene_expression (expression) of CD38 in B-cells
12) Confidence 0.29 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2695011 Disease Relevance 0.19 Pain Relevance 0
Decreased expression of CXCR5 on blood B-cells [7] but increased proportions of CD38-expressing B-cells have been described as a consequence of abnormal trafficking of germinal centre (GC)-like B-cells into blood [8].
Gene_expression (expressing) of CD38 in B-cells
13) Confidence 0.29 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2695011 Disease Relevance 0.59 Pain Relevance 0.03
As tertiary aims we will explore differences in CD8+ T-cell count, expression of activation markers (CD38 and HLA-DR) on CD4 and CD8 T cells, cholesterol metabolism, LFA-1/ICAM-1 function, Rho GTPases function and clinical evolution between treated and not treated HIV-1-infected individuals.


Gene_expression (expression) of CD38 in T cells associated with acquired immune deficiency syndrome or hiv infection
14) Confidence 0.26 Published 2009 Journal Trials Section Abstract Doc Link PMC2705367 Disease Relevance 0.58 Pain Relevance 0
CD38, CD69 and PD1 expression was investigated (blood and tissues) as a measure of T cell activation (Fig.
Spec (investigated) Gene_expression (expression) of CD38 in blood
15) Confidence 0.25 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2943484 Disease Relevance 0 Pain Relevance 0.07
There were no differences between groups in frequency of activated CD8 T cells, co-expressing markers of activation CD38 and HLA-DR, at baseline (Table 2).
Gene_expression (expressing) of CD38 in T cells
16) Confidence 0.22 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2914784 Disease Relevance 0.07 Pain Relevance 0.18
Immune activation is also suggested by an elevation of pro-inflammatory cytokines, an increased expression of T lymphocyte activation markers, such as CD26 and CD38 [12] and decreased function of natural killer (NK) cells (for review see [13]).
Gene_expression (expression) of CD38 in T lymphocyte associated with inflammation and cytokine
17) Confidence 0.20 Published 2010 Journal Nutr Metab (Lond) Section Body Doc Link PMC2964729 Disease Relevance 1.22 Pain Relevance 0.50
Leflunomide administration reduced cycling of CD4 T cells (by ex vivo bromodeoxyuridine uptake and Ki67 expression) and decreased expression of activation markers (HLA-DR/CD38 co-expression) on CD8 T cells in peripheral blood.
Gene_expression (expression) of CD38 in blood associated with leflunomide
18) Confidence 0.19 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2914784 Disease Relevance 0.91 Pain Relevance 0.34
A decrease in both BrdU incorporation by CD4 T cells and CD38/HLA-DR expression on CD8 T cells was also seen in the treatment group compared to the placebo group indicating a decrease in T cell cycling and activation.
Gene_expression (expression) of CD38 in T cells
19) Confidence 0.19 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2914784 Disease Relevance 0.54 Pain Relevance 0.19
Human leptin was found to stimulate proliferation and activation of human circulating monocytes in vitro, promoting the expression of activation markers: CD69, CD25, CD38, and CD71, in addition to increasing the expression of monocytes surface markers, such as HLA-DR, CD11b, and CD11c [24].
Gene_expression (expression) of CD38 in monocytes
20) Confidence 0.19 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2846344 Disease Relevance 0.63 Pain Relevance 0.36

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