INT76496

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Context Info
Confidence 0.48
First Reported 1998
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.30
Pain Relevance 1.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Adora2a) enzyme binding (Adora2a) signal transducer activity (Adora2a)
Anatomy Link Frequency
spinal cord 1
Adora2a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 130 99.82 Very High Very High Very High
Spinal cord 9 99.52 Very High Very High Very High
qutenza 3 98.12 Very High Very High Very High
Dorsal horn 1 97.68 Very High Very High Very High
substance P 4 97.28 Very High Very High Very High
primary afferent fibers 1 96.16 Very High Very High Very High
Glutamate 14 93.20 High High
adenocard 152 92.08 High High
antagonist 35 89.32 High High
analgesia 1 84.44 Quite High
Disease Link Frequency Relevance Heat
Drug Induced Neurotoxicity 2 88.52 High High
Targeted Disruption 1 71.44 Quite High
Necrosis 2 68.64 Quite High
Cancer 11 68.28 Quite High
Hypoxia 13 5.00 Very Low Very Low Very Low
Disease 12 5.00 Very Low Very Low Very Low
Neurological Disease 5 5.00 Very Low Very Low Very Low
Bordatella Infection 4 5.00 Very Low Very Low Very Low
Obesity 4 5.00 Very Low Very Low Very Low
INFLAMMATION 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This pretreatment did not affect the agonist-induced desensitization of the A2AR.
Localization (desensitization) of A2AR associated with agonist
1) Confidence 0.48 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2245999 Disease Relevance 0.14 Pain Relevance 0.27
Our results suggest that the primary localization of the alpha2A-AR in the rat spinal cord is on the terminals of capsaicin-sensitive, substance P (SP)-containing primary afferent fibers.
Localization (localization) of alpha2A-AR in spinal cord associated with qutenza, primary afferent fibers, substance p and spinal cord
2) Confidence 0.41 Published 1998 Journal J. Neurosci. Section Abstract Doc Link 9671679 Disease Relevance 0 Pain Relevance 0.74
In this study, the functionality of A1Rs was not affected by NMDA preconditioning, but this treatment promoted A2AR desensitization in concert with A1R activation [83].
Localization (desensitization) of A2AR
3) Confidence 0.34 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072922 Disease Relevance 0.16 Pain Relevance 0.53

General Comments

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