INT76698

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Context Info
Confidence 0.42
First Reported 1998
Last Reported 2010
Negated 1
Speculated 1
Reported most in Abstract
Documents 7
Total Number 8
Disease Relevance 7.37
Pain Relevance 6.02

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

phosphatase activity (Pgp)
Anatomy Link Frequency
brain 2
Pgp (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Pain 329 100.00 Very High Very High Very High
depression 73 99.84 Very High Very High Very High
Morphine 10 99.36 Very High Very High Very High
IPN 12 99.16 Very High Very High Very High
backache 30 98.94 Very High Very High Very High
antinociception 2 97.20 Very High Very High Very High
Piles 8 94.52 High High
analgesia 2 93.20 High High
Analgesic 2 91.08 High High
opiate 2 90.68 High High
Disease Link Frequency Relevance Heat
Pain 328 100.00 Very High Very High Very High
Depression 75 99.84 Very High Very High Very High
Attention Deficit Hyperactivity Disorder 3 99.84 Very High Very High Very High
Inflammatory Pain 12 99.16 Very High Very High Very High
Low Back Pain 30 98.94 Very High Very High Very High
Anorectal Disorders 8 94.52 High High
Hyperalgesia 4 90.16 High High
Adhesions 1 90.16 High High
INFLAMMATION 19 89.64 High High
Increased Venous Pressure Under Development 3 88.76 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This indicates that the CIP induced decrease in morphine transport was the result of an increase in Pgp activity at the BBB.
Positive_regulation (increase) of Pgp associated with ipn and morphine
1) Confidence 0.42 Published 2007 Journal J. Neurochem. Section Abstract Doc Link 17697052 Disease Relevance 1.16 Pain Relevance 1.69
Several of the previously identified risk factors for PGP in pregnancy are similar to those reported for LBP and for other musculoskeletal disorders and are not specific for PGP [36,37].
Neg (not) Positive_regulation (specific) of PGP associated with pain and backache
2) Confidence 0.36 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2890600 Disease Relevance 1.36 Pain Relevance 1.36
PGP was assumed to increase with weight bearing activities like walking and lifting objects [6,9].
Positive_regulation (increase) of PGP associated with pain
3) Confidence 0.33 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2890600 Disease Relevance 0.90 Pain Relevance 0.55
Western blot analysis of enriched brain microvessel fractions showed increased Pgp expression 3 h post-CIP.
Positive_regulation (increased) of Pgp in brain associated with ipn
4) Confidence 0.30 Published 2007 Journal J. Neurochem. Section Abstract Doc Link 17697052 Disease Relevance 1.23 Pain Relevance 1.53
TSB also moderately stimulated PgP ATPase activity.
Positive_regulation (stimulated) of PgP
5) Confidence 0.25 Published 2007 Journal Xenobiotica Section Abstract Doc Link 17455112 Disease Relevance 0 Pain Relevance 0
The increases in PGP- and GAP-immunopositive area fractions were highly significant (P > 0.01).
Positive_regulation (increases) of PGP
6) Confidence 0.23 Published 1998 Journal Int J Colorectal Dis Section Abstract Doc Link 9689564 Disease Relevance 0.79 Pain Relevance 0.48
Taken collectively, our findings indicate that TSB is a substrate for PgP and MRP1 and that drug resistance to TSB therapy and drug interactions may occur through PgP and MRP1 modulation.
Spec (may) Positive_regulation (occur) of PgP
7) Confidence 0.23 Published 2007 Journal Xenobiotica Section Abstract Doc Link 17455112 Disease Relevance 0 Pain Relevance 0
Hyperactivity of MRD PGP induced by depression results in reduced transport of glucocorticoids to the brain, leading to glucocorticoid resistance [31].
Positive_regulation (induced) of PGP in brain associated with depression and attention deficit hyperactivity disorder
8) Confidence 0.01 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2994859 Disease Relevance 1.92 Pain Relevance 0.42

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