INT7673

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Context Info
Confidence 0.42
First Reported 1984
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 31
Total Number 32
Disease Relevance 7.90
Pain Relevance 8.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (ENG) cell motility (ENG) cell adhesion (ENG)
nucleolus (ENG) nucleus (ENG) cytoplasm (ENG)
Anatomy Link Frequency
plasma 3
hypothalamus 3
immune cells 2
neurons 1
pituitary 1
ENG (Homo sapiens)
Pain Link Frequency Relevance Heat
antinociception 85 99.58 Very High Very High Very High
narcan 19 99.58 Very High Very High Very High
alcohol 9 99.54 Very High Very High Very High
antagonist 30 99.40 Very High Very High Very High
dexamethasone 10 98.72 Very High Very High Very High
Neuropeptide 12 98.16 Very High Very High Very High
Central nervous system 25 98.12 Very High Very High Very High
qutenza 5 97.92 Very High Very High Very High
mu opioid receptor 1 97.48 Very High Very High Very High
Somatostatin 10 97.40 Very High Very High Very High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 26 100.00 Very High Very High Very High
Toxicity 11 100.00 Very High Very High Very High
Reprotox - General 1 58 99.28 Very High Very High Very High
Nephrotoxicity 1 98.80 Very High Very High Very High
Stroke 20 98.76 Very High Very High Very High
Stress 84 98.72 Very High Very High Very High
Disease 58 98.36 Very High Very High Very High
Aids-related Complex 4 97.60 Very High Very High Very High
Heart Rate Under Development 11 96.00 Very High Very High Very High
Pulmonary Disease 109 95.20 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our results show that chronic consumption of alcohol induces a significant decrease in beta-endorphin (beta-end) plasma levels regardless of either the disease suffered by the alcoholic patient or of the time of abstinence studied (one month maximum).
Negative_regulation (decrease) of end in plasma associated with disease and alcohol
1) Confidence 0.42 Published 1990 Journal Alcohol Section Abstract Doc Link 2222843 Disease Relevance 0.18 Pain Relevance 0.18
1 at 50 µg/ml (R&D Systems, Minneapolis, MN), the p38MAPK inhibitor SB203580 (10 µM), the ERKMAPK inhibitor PD98059 (10 µM), the ALK-5 blocker at 10 µM SB-431542 (Tocris, Bristol, UK), and anti-CD105 at 1 µg/ml (BD Bioscience, Franklin Lakes, USA), as described [24].


Negative_regulation (inhibitor) of anti-CD105
2) Confidence 0.34 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2842433 Disease Relevance 0 Pain Relevance 0.18
A significant correlation between the beta-END reduction in the response and the reduction in the HRSD score (r=.656; p<.001) was observed.
Negative_regulation (reduction) of beta-END
3) Confidence 0.26 Published 2008 Journal Prog. Neuropsychopharmacol. Biol. Psychiatry Section Body Doc Link 18725263 Disease Relevance 0 Pain Relevance 0
After 8 weeks of citalopram treatment depressed patients showed a significant decrease in the beta-END response (Deltamax: p<.001; AUC: p<.001).
Negative_regulation (decrease) of beta-END
4) Confidence 0.26 Published 2008 Journal Prog. Neuropsychopharmacol. Biol. Psychiatry Section Body Doc Link 18725263 Disease Relevance 0 Pain Relevance 0
This is important, as genistein can therapeutically compensate for endoglin loss, which occurs in prostate cancer progression.
Negative_regulation (loss) of endoglin associated with reprotox - general 1
5) Confidence 0.16 Published 2010 Journal Cancer Metastasis Rev Section Body Doc Link PMC2933845 Disease Relevance 0.50 Pain Relevance 0
Although this complex is held to reduce Cd binding and toxicity using certain toxicologic end points, it can produce early nephrotoxicity in the form of proximal tubular dysfunction [International Programme on Chemical Safety (1992) and references therein].
Negative_regulation (reduce) of end in proximal associated with nephrotoxicity and toxicity
6) Confidence 0.13 Published 2007 Journal Environ Health Perspect Section Body Doc Link PMC1852676 Disease Relevance 0.28 Pain Relevance 0
Service development in end of life care
Negative_regulation (development) of end
7) Confidence 0.09 Published 2008 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2528206 Disease Relevance 0.33 Pain Relevance 0.04
The left ventricular (LV) pressure-volume relationship showed stable decreases in LV end-systolic elastance (Ees) and preload recruitable stroke work.
Negative_regulation (decreases) of end-systolic elastance associated with stroke
8) Confidence 0.09 Published 1997 Journal ASAIO J. Section Abstract Doc Link 9360072 Disease Relevance 0.58 Pain Relevance 0.13
By this infusion, end-tidal-CO2 and CVP gradually decreased and operation was concluded successfully.
Negative_regulation (decreased) of end-tidal-CO2
9) Confidence 0.08 Published 1999 Journal Masui Section Abstract Doc Link 10087835 Disease Relevance 0.34 Pain Relevance 0.09
For example, even though the control END levels in Fig. 4A and Fig. 4B were comparable, the END levels after different doses of POMC-MIDGE-NLS varied between the two graphs.
Negative_regulation (levels) of END
10) Confidence 0.07 Published 2009 Journal Mol Pain Section Body Doc Link PMC2797781 Disease Relevance 0.50 Pain Relevance 0.32
l by repetitive freeze-thaw cycles, unsoluble material was removed by centrifugation, and END immunoreactivity was measured in 100 ?
Negative_regulation (measured) of END
11) Confidence 0.07 Published 2009 Journal Mol Pain Section Body Doc Link PMC2797781 Disease Relevance 0.08 Pain Relevance 0.19
The primary composite end point of cardiac mortality and morbidity was reduced equally by both groups.8 However, amlodipine was associated with a statistically significant 16% reduction in the incidence of myocardial infarction and a near-significant reduction in stroke (Table 1).
Negative_regulation (reduced) of end associated with stroke and myocardial infarction
12) Confidence 0.05 Published 2009 Journal Vascular Health and Risk Management Section Body Doc Link PMC2686256 Disease Relevance 1.09 Pain Relevance 0
This impaired antinociception was paralleled by a decrease in END content as well as a decrease in the number of END-containing immune cells in inflamed tissue (Machelska et al 1998).
Negative_regulation (decrease) of END in immune cells associated with antinociception
13) Confidence 0.05 Published 2005 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1661636 Disease Relevance 0.49 Pain Relevance 0.80
Both ADX and CB replacement significantly reduced the stimulatory effect of CRH (10(-8) M) upon beta-END release.
Negative_regulation (reduced) of beta-END
14) Confidence 0.05 Published 1991 Journal Neuroendocrinology Section Abstract Doc Link 1766548 Disease Relevance 0 Pain Relevance 0.06
This decrease in plasma ACTH and beta-END levels with heavy drinking was more pronounced in female than male subjects of the 30-44 and 45-60 age groups.
Negative_regulation (decrease) of beta-END in plasma
15) Confidence 0.04 Published 2003 Journal Alcohol. Clin. Exp. Res. Section Body Doc Link 12658106 Disease Relevance 0.06 Pain Relevance 0
This impaired antinociception was paralleled by a decrease in END content as well as a decrease in the number of END-containing immune cells in inflamed tissue (Machelska et al 1998).
Negative_regulation (decrease) of END in immune cells associated with antinociception
16) Confidence 0.04 Published 2005 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1661636 Disease Relevance 0.46 Pain Relevance 0.75
The end-effector force, the velocity of the end-effector, the work toward target and the work away from target in the tangential direction of the tunnel are presented in Figure 3.
Negative_regulation (presented) of end-effector
17) Confidence 0.02 Published 2010 Journal J Neuroeng Rehabil Section Body Doc Link PMC2965146 Disease Relevance 0.09 Pain Relevance 0
Local infusion of beta-endorphin (beta-END) into the medial preoptic area (MPOA) dose-dependently impaired the gating of the copulatory response and the execution of the sexual performance of sexually experienced, intact male rats.
Negative_regulation (impaired) of beta-END in preoptic area associated with urological neuroanatomy
18) Confidence 0.02 Published 1995 Journal Behav. Neurosci. Section Abstract Doc Link 7734068 Disease Relevance 0.42 Pain Relevance 0.29
The purpose of this study was to determine the plasma levels of beta-endorphin (beta-END) and ACTH in the perioperative period, define correlations of hormonal plasma levels with clinical parameters and establish the effect of droperidol premedication on hormonal levels and clinical parameters. 2.
Spec (determine) Negative_regulation (determine) of beta-END in plasma
19) Confidence 0.02 Published 1989 Journal Gen. Pharmacol. Section Abstract Doc Link 2546852 Disease Relevance 0 Pain Relevance 0.06
E2V administration reverted the ovariectomy-induced reduction in allopregnanolone and beta-END.
Negative_regulation (reduction) of beta-END
20) Confidence 0.02 Published 2006 Journal Neuroendocrinology Section Abstract Doc Link 16931878 Disease Relevance 0 Pain Relevance 0.28

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