INT76741

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Context Info
Confidence 0.68
First Reported 1997
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 7
Total Number 8
Disease Relevance 0.22
Pain Relevance 5.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (OPRK1) signal transducer activity (OPRK1)
Anatomy Link Frequency
spinal 1
granulosa cells 1
OPRK1 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 58 100.00 Very High Very High Very High
Dynorphin 14 100.00 Very High Very High Very High
Kappa opioid receptor 13 100.00 Very High Very High Very High
Opioid 11 100.00 Very High Very High Very High
Endogenous opioid 4 100.00 Very High Very High Very High
antinociception 18 99.84 Very High Very High Very High
opioid receptor 17 99.84 Very High Very High Very High
Acupuncture 3 99.62 Very High Very High Very High
Buprenorphine 4 99.24 Very High Very High Very High
tail-flick 1 97.76 Very High Very High Very High
Disease Link Frequency Relevance Heat
Coronary Heart Disease 2 57.92 Quite High
Hydrocephalus 2 52.72 Quite High
Targeted Disruption 8 5.00 Very Low Very Low Very Low
Osteoporosis 2 5.00 Very Low Very Low Very Low
Bordatella Infection 2 5.00 Very Low Very Low Very Low
Disease 2 5.00 Very Low Very Low Very Low
Influenza Virus Infection 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Antisense to all three opioid receptors attenuated the effect of diazoxide, suggesting that diazoxide is inducing the release of endogenous opioids activating the mu(MOR-1)-, delta(DOR-1)-, and kappa(KOR-1)-opioid receptors.
Localization (release) of KOR associated with endogenous opioid and opioid receptor
1) Confidence 0.68 Published 1999 Journal Eur. J. Pharmacol. Section Abstract Doc Link 10611434 Disease Relevance 0 Pain Relevance 1.21
The kappa-opioid receptor is present in porcine ovaries: localization in granulosa cells.
Localization (localization) of kappa-opioid receptor in granulosa cells associated with kappa opioid receptor
2) Confidence 0.67 Published 1997 Journal Cytobios Section Title Doc Link 9693886 Disease Relevance 0 Pain Relevance 0.30
Research linking the effects of acupuncture to the release of dynorphin, the endogenous ligand for the kappa-receptor, raised the possibility that buprenorphine may block acupuncture's effects.
Localization (release) of kappa-receptor associated with dynorphin, acupuncture and buprenorphine
3) Confidence 0.67 Published 1999 Journal J Altern Complement Med Section Abstract Doc Link 10630350 Disease Relevance 0 Pain Relevance 0.99
Intrathecal administration of anandamide, delta9-tetrahydrocannabinol (THC) and (-)-3-[2-hydroxy-4-(1,1-dimethyheptyl)ptyl)phenyl]-4-(3-hydr oxypropyl)-cicloexan-1-ol (CP55,940) induced spinal antinociception accompanied by differential kappa-opioid receptor involvement and dynorphin A peptide release.
Localization (release) of kappa-opioid receptor in spinal associated with antinociception, dynorphin, kappa opioid receptor and intrathecal
4) Confidence 0.20 Published 1999 Journal Eur. J. Pharmacol. Section Abstract Doc Link 10493099 Disease Relevance 0 Pain Relevance 0.79
Ro1 (RASSL opioid 1), the prototype RASSL based on a Gi-coupled ?
Localization (based) of RASSL opioid 1 associated with opioid
5) Confidence 0.18 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2267039 Disease Relevance 0.11 Pain Relevance 0.24
Ro1 (RASSL opioid 1), the prototype RASSL based on a Gi-coupled ?
Localization (coupled) of RASSL opioid 1 associated with opioid
6) Confidence 0.18 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2267039 Disease Relevance 0.11 Pain Relevance 0.24
The effects of mu, delta and kappa receptor agonists on both basal and LH-induced progesterone (P4) secretion were negligible.
Localization (secretion) of kappa receptor associated with agonist
7) Confidence 0.16 Published 2004 Journal Reprod. Domest. Anim. Section Abstract Doc Link 15129917 Disease Relevance 0 Pain Relevance 0.72
It concludes that the antinociception induced by supraspinally administered endomorphin-2 is in part mediated through the release of endogenous kappa-opioid peptide dynorphin A, which is caused by the stimulation of distinct subclass of micro1-opioid receptor.
Localization (release) of kappa-opioid peptide associated with antinociception, dynorphin, opioid receptor and opioid
8) Confidence 0.01 Published 2008 Journal Peptides Section Abstract Doc Link 18571771 Disease Relevance 0 Pain Relevance 1.40

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