INT7702

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Context Info
Confidence 0.77
First Reported 1989
Last Reported 2003
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 3.33
Pain Relevance 0.89

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (Asrgl1) nucleus (Asrgl1) protein maturation (Asrgl1)
cytoplasm (Asrgl1)
Anatomy Link Frequency
lymphocytes 1
Asrgl1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
headache 2 97.60 Very High Very High Very High
Morphine 4 95.40 Very High Very High Very High
imagery 1 95.12 Very High Very High Very High
Physical dependence 3 94.88 High High
cva 14 83.48 Quite High
agonist 2 73.52 Quite High
narcan 6 54.16 Quite High
Abstinence syndrome 4 52.40 Quite High
Analgesic 2 25.00 Low Low
antagonist 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Thrombosis 5 99.90 Very High Very High Very High
Precursor Cell Lymphoblastic Leukemia-lymphoma 2 99.84 Very High Very High Very High
Thrombosis Related Under Development 6 98.98 Very High Very High Very High
Headache 2 97.60 Very High Very High Very High
Breast Cancer 1 95.56 Very High Very High Very High
Drug Dependence 3 94.88 High High
Syndrome 9 89.96 High High
Cancer 17 89.16 High High
Cv General 3 Under Development 14 83.48 Quite High
Lymphatic System Cancer 2 82.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
No positive reaction was demonstrated for L-AATase while L-asparaginase shown to be present in lymphocytes and lymphoblastic cells.
Gene_expression (present) of L-asparaginase in lymphocytes
1) Confidence 0.77 Published 1995 Journal Eur J Histochem Section Abstract Doc Link 8630437 Disease Relevance 0.18 Pain Relevance 0.09
These observations lead us to suggest that L-asparaginase is the enzyme mainly responsible for the synthesis of the L-aspartic acid necessary for satisfying the living requirements of lymphoid cells.
Gene_expression (synthesis) of L-asparaginase
2) Confidence 0.66 Published 1995 Journal Eur J Histochem Section Abstract Doc Link 8630437 Disease Relevance 0.17 Pain Relevance 0.08
[Cerebral thrombosis in a child with acute lymphocytic leukemia during L-asparaginase therapy].
Gene_expression (therapy) of L-asparaginase associated with precursor cell lymphoblastic leukemia-lymphoma and thrombosis related under development
3) Confidence 0.24 Published 1989 Journal Rinsho Ketsueki Section Title Doc Link 2601047 Disease Relevance 0.39 Pain Relevance 0.15
It has previously been shown that subchronic and acute administration of L-asparaginase and glutaminase inhibitors D-Aspartic acid (D-ASP) and prolyl-leucyl-glycinamide (PLG) intensifies and attenuates morphine (M) physical dependence, respectively, by the inhibition of ASP and glutamic acid (GLU) production, and subsequently their normal releases.
Gene_expression (administration) of L-asparaginase associated with physical dependence and morphine
4) Confidence 0.14 Published 1992 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 1355295 Disease Relevance 0.28 Pain Relevance 0.40
The best-known associations with thrombosis are L-asparaginase, which is typically used in the induction therapy of acute lymphocytic leukemia, and combination hormonal therapy and chemotherapy for breast cancer.
Gene_expression (used) of L-asparaginase associated with precursor cell lymphoblastic leukemia-lymphoma, breast cancer and thrombosis
5) Confidence 0.07 Published 2003 Journal Neurol Clin Section Abstract Doc Link 12690649 Disease Relevance 2.31 Pain Relevance 0.17

General Comments

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