INT77250

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Context Info
Confidence 0.44
First Reported 1998
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 3.32
Pain Relevance 2.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (Nr3c1) intracellular (Nr3c1) DNA binding (Nr3c1)
protein complex (Nr3c1) cytoplasm (Nr3c1) cytosol (Nr3c1)
Anatomy Link Frequency
medial 2
brain 2
Nr3c1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Eae 7 100.00 Very High Very High Very High
fluoxetine 10 99.74 Very High Very High Very High
Desipramine 6 99.34 Very High Very High Very High
amygdala 3 98.92 Very High Very High Very High
antidepressant 6 98.76 Very High Very High Very High
Hippocampus 6 96.28 Very High Very High Very High
dexamethasone 3 86.48 High High
Neuropathic pain 3 85.56 High High
Lasting pain 7 85.44 High High
Limbic system 4 81.36 Quite High
Disease Link Frequency Relevance Heat
Injury 7 100.00 Very High Very High Very High
Carney Complex 13 97.44 Very High Very High Very High
Urological Neuroanatomy 5 94.88 High High
Stress 6 94.48 High High
Nociception 2 87.92 High High
Neuropathic Pain 3 85.56 High High
Pain 8 85.44 High High
Disease 10 81.00 Quite High
Multiple Endocrine Neoplasia 1 77.60 Quite High
Syndrome 20 75.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover, glucocorticoid receptor mRNA expression in CCI rats was increased in the medial and central amygdala, unaffected in the paraventricular nucleus, and decreased in the hippocampus.
Positive_regulation (increased) of Gene_expression (expression) of glucocorticoid receptor mRNA in medial associated with eae, hippocampus and amygdala
1) Confidence 0.44 Published 2006 Journal Physiol. Behav. Section Abstract Doc Link 16647726 Disease Relevance 1.70 Pain Relevance 1.32
Gender-related differences in the expression and functional properties of the hepatic glucocorticoid receptor were studied before and after antidepressant fluoxetine administration to both unstressed and rats exposed to a chronic social isolation stress.
Positive_regulation (differences) of Gene_expression (expression) of glucocorticoid receptor associated with stress, antidepressant and fluoxetine
2) Confidence 0.40 Published 2010 Journal Eur. J. Pharmacol. Section Abstract Doc Link 20122922 Disease Relevance 0.09 Pain Relevance 0.33
Since chronic desipramine, and not fluoxetine, is able to increase hippocampal glucocorticoid receptor (GR) expression, interactions of GR with CREB and SP1 may determine the lack of effect of desipramine on binding activity of the two latter transcription factors in this brain region. 6.
Positive_regulation (increase) of Gene_expression (expression) of glucocorticoid receptor in brain associated with desipramine and fluoxetine
3) Confidence 0.18 Published 1998 Journal Prog. Neuropsychopharmacol. Biol. Psychiatry Section Abstract Doc Link 9723120 Disease Relevance 0.41 Pain Relevance 0.92
This delayed paradoxical response was associated with an increased expression of the glucocorticoid receptor (GR); its molecular basis still remains to be clarified [11].
Positive_regulation (increased) of Gene_expression (expression) of glucocorticoid receptor
4) Confidence 0.03 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2923167 Disease Relevance 1.05 Pain Relevance 0.07

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