INT77356

Context Info Confidence 0.63 First Reported 1998 Last Reported 1999 Negated 1 Speculated 0 Reported most in Abstract Documents 2 Total Number 2 Disease Relevance 0.09 Pain Relevance 1.13

intracellular (Gnai1) GTPase activity (Gnai1) cytoplasm (Gnai1) signal transducer activity (Gnai1) signal transduction (Gnai1) nucleus (Gnai1)

Anatomy Link Frequency striatum 1 Gnai1 (Mus musculus)

Pain Link Frequency Relevance Heat Opioid 3 89.44 Potency 3 89.32 Analgesic 2 89.00 Morphine 2 88.52 fortral 3 88.40 analgesia 1 88.24 MU agonist 1 75.00 Enkephalin 1 70.48 Intracerebroventricular 1 57.80 nociceptor 1 25.00

Disease Link Frequency Relevance Heat Bordatella Infection 1 92.04

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In contrast, no changes in Gialpha2 mRNA in mouse striatum were noted at any time after antisense treatment.

Neg (no) Positive_regulation (changes) of Gialpha2 in striatum

1) Confidence 0.63 Published 1998 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9729412 Disease Relevance 0 Pain Relevance 0.95

These findings suggest that metabotropic sigma receptors are selectively coupled to Gi1 protein.

Positive_regulation (coupled) of Gi1

2) Confidence 0.04 Published 1999 Journal Neurosci. Lett. Section Abstract Doc Link 10400084 Disease Relevance 0.09 Pain Relevance 0.17

General Comments

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