INT77357

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Context Info
Confidence 0.50
First Reported 1998
Last Reported 1998
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 3
Disease Relevance 0.80
Pain Relevance 0.83

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Gstt1) cytoplasm (Gstt1)
Anatomy Link Frequency
liver 1
Gstt1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cINOD 11 97.20 Very High Very High Very High
aspirin 1 25.00 Low Low
Disease Link Frequency Relevance Heat
INFLAMMATION 4 97.00 Very High Very High Very High
Gastrointestinal Neoplasms 2 95.44 Very High Very High Very High
Cancer 4 89.12 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We now investigated whether the NSAIDs indomethacin, relafen, sulindac, ibuprofen, piroxicam, and acetyl salicylic acid (ASA), incorporated individually into the diet at 25, 200, 320, 400, 400 and 400 mg/kg, respectively, affect gastrointestinal GSTT1-1 and GSTT2-2 levels in male Wistar rats.
Regulation (affect) of GSTT1-1 associated with cinod
1) Confidence 0.50 Published 1998 Journal Biochim. Biophys. Acta Section Abstract Doc Link 9729437 Disease Relevance 0.30 Pain Relevance 0.49
Effects of dietary anticarcinogens on rat gastrointestinal glutathione S-transferase theta 1-1 levels.
Regulation (Effects) of glutathione S-transferase theta 1-1
2) Confidence 0.47 Published 1998 Journal Carcinogenesis Section Title Doc Link 9855024 Disease Relevance 0.27 Pain Relevance 0.19
We therefore investigated whether the anticarcinogens alpha-angelicalactone, alpha-tocopherol, beta-carotene, coumarin, ellagic acid, flavone, indole-3-carbinol, d-limonene, oltipraz, phenethylisothiocyanate (PEITC) and the sulphoraphane analogue compound-30 affect gastrointestinal rGSTT1-1 protein levels in male Wistar rats. rGSTT1-1 protein levels were determined in cytosolic fractions of liver and oesophageal-, gastric-, small intestinal- and colonic mucosa by densitometrical analyses of western blots after immunodetection with an anti human GSTT1-1 monoclonal antibody, that cross-reacts with rGSTT1-1.
Regulation (affect) of rGSTT1-1 in liver
3) Confidence 0.41 Published 1998 Journal Carcinogenesis Section Abstract Doc Link 9855024 Disease Relevance 0.23 Pain Relevance 0.14

General Comments

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