INT77368

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Context Info
Confidence 0.35
First Reported 1998
Last Reported 2008
Negated 0
Speculated 0
Reported most in Title
Documents 3
Total Number 3
Disease Relevance 1.86
Pain Relevance 1.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il6) aging (Il6) extracellular region (Il6)
Anatomy Link Frequency
macrophages 2
brain 2
Il6 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Thermal hyperalgesia 2 99.80 Very High Very High Very High
Calcitonin gene-related peptide 14 99.20 Very High Very High Very High
Pain 1 97.44 Very High Very High Very High
corticosteroid 24 95.76 Very High Very High Very High
IPN 1 93.88 High High
Neuropathic pain 3 91.44 High High
Inflammation 4 88.48 High High
antagonist 4 76.96 Quite High
Sciatic nerve 1 72.80 Quite High
Inflammatory stimuli 1 65.64 Quite High
Disease Link Frequency Relevance Heat
Hyperalgesia 2 99.80 Very High Very High Very High
Neuroma 3 99.42 Very High Very High Very High
Diabetic Nephropathy 1 98.24 Very High Very High Very High
Pain 1 97.44 Very High Very High Very High
Disease 4 94.00 High High
Inflammatory Pain 1 93.88 High High
Acquired Immune Deficiency Syndrome Or Hiv Infection 1 93.64 High High
Dementia 1 93.44 High High
Stroke 1 91.96 High High
Neuropathic Pain 3 91.44 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The equation describing the up-regulation of IL-6 receptor type 1 mRNA (IL6R1m) time profile following MPL treatment is:
Regulation (equation) of Regulation (regulation) of IL-6
1) Confidence 0.35 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733097 Disease Relevance 0 Pain Relevance 0.12
Role of the brain in interleukin-6 modulation.
Regulation (Role) of Regulation (modulation) of interleukin-6 in brain
2) Confidence 0.27 Published 1998 Journal Neuroimmunomodulation Section Title Doc Link 9730688 Disease Relevance 0.89 Pain Relevance 0.10
Increased calcitonin gene-related peptide in neuroma and invading macrophages is involved in the up-regulation of interleukin-6 and thermal hyperalgesia in a rat model of mononeuropathy.
Regulation (involved) of Regulation (regulation) of interleukin-6 in macrophages associated with thermal hyperalgesia, neuroma, diabetic nephropathy and calcitonin gene-related peptide
3) Confidence 0.27 Published 2006 Journal J. Neurochem. Section Title Doc Link 16805807 Disease Relevance 0.98 Pain Relevance 1.24

General Comments

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