INT77385

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Context Info
Confidence 0.75
First Reported 1998
Last Reported 2009
Negated 1
Speculated 1
Reported most in Abstract
Documents 18
Total Number 21
Disease Relevance 4.69
Pain Relevance 3.92

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Esr2) plasma membrane (Esr2) nucleus (Esr2)
enzyme binding (Esr2) DNA binding (Esr2) cytoplasm (Esr2)
Anatomy Link Frequency
brain 4
PVN 2
sensory neurons 1
hypothalamus 1
pituitary 1
Esr2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Neuropeptide 24 100.00 Very High Very High Very High
orphanin 8 100.00 Very High Very High Very High
Locus ceruleus 31 99.98 Very High Very High Very High
Hippocampus 19 98.88 Very High Very High Very High
Enkephalin 30 97.64 Very High Very High Very High
nociceptor 3 93.60 High High
Calcitonin gene-related peptide 1 91.28 High High
substance P 1 89.96 High High
Opioid 12 89.84 High High
antidepressant 12 82.56 Quite High
Disease Link Frequency Relevance Heat
Apoptosis 342 98.98 Very High Very High Very High
Congenital Anomalies 133 98.88 Very High Very High Very High
Schizophrenia 660 98.82 Very High Very High Very High
Suicidal Behaviour 6 97.76 Very High Very High Very High
Hypertrophy 5 93.80 High High
Galactorrhea 12 91.56 High High
Death 36 85.04 High High
Depression 22 80.84 Quite High
Stress 62 78.68 Quite High
Overactive Bladder 2 78.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the PVN, roughly half of the ERbeta expression was colocalized with the prepro-orphanin FQ mRNA, which was comparable to the colocalization observed between the ERbeta and AVP mRNAs in the same region.
Gene_expression (expression) of ERbeta associated with orphanin
1) Confidence 0.75 Published 2003 Journal Anat. Embryol. Section Abstract Doc Link 12690447 Disease Relevance 0 Pain Relevance 0.53
A small percentage of ERbeta-expressing cells in the dorsocaudal and ventromedial zones of the parvocellular PVN were also ENK positive.
Gene_expression (expressing) of ERbeta in PVN associated with enkephalin
2) Confidence 0.56 Published 1998 Journal J. Neurobiol. Section Abstract Doc Link 9733072 Disease Relevance 0 Pain Relevance 0.10
Very few AVP-ir neurons expressing ERbeta transcript were found throughout the rat brain, although the medial PVN displayed some scattered double-labeled cells (<5%).
Gene_expression (expressing) of ERbeta in brain
3) Confidence 0.56 Published 1998 Journal J. Neurobiol. Section Abstract Doc Link 9733072 Disease Relevance 0 Pain Relevance 0.11
This study shows a differential pattern of expression of both receptors in the brain of intact rats and that ERbeta is expressed at various levels in distinct neuropeptidergic populations, including OT, CRF, and ENK.
Gene_expression (expressed) of ERbeta in brain associated with enkephalin
4) Confidence 0.56 Published 1998 Journal J. Neurobiol. Section Abstract Doc Link 9733072 Disease Relevance 0 Pain Relevance 0.18
Indeed, more than 60-80% of the CRF-containing cells located in the caudolateral division of the parvocellular PVN exhibited a positive hybridization signal for ERbeta mRNA, whereas very few (<5%) neuroendocrine CRF-ir parvocellular neurons of the medial PVN expressed the gene encoding ERbeta.
Gene_expression (expressed) of ERbeta in PVN
5) Confidence 0.56 Published 1998 Journal J. Neurobiol. Section Abstract Doc Link 9733072 Disease Relevance 0 Pain Relevance 0.09
The purpose of the present study was to define the neuroanatomical organization of each receptor subtype using a side-by-side approach and to characterize the cellular population (s) expressing the ERbeta transcript in the endocrine hypothalamus using immunohistochemistry combined with in situ hybridization.
Gene_expression (expressing) of ERbeta in hypothalamus
6) Confidence 0.56 Published 1998 Journal J. Neurobiol. Section Abstract Doc Link 9733072 Disease Relevance 0 Pain Relevance 0.18
A high percentage of the ERbeta-expressing neurons located in the ventro- and dorsomedial PVN are of OT type; 40% of the OT-ir cells forming the medial magnocellular and ventromedial parvocellular PVN showed a clear hybridization signal for ERbeta mRNA, whereas a lower percentage (15-20%) of OT neurons were positive in the caudal parvocellular PVN and no double-labeled cells were found in the rostral PVN and other regions of the brain with the exception of the SON.
Gene_expression (expressing) of ERbeta in brain
7) Confidence 0.56 Published 1998 Journal J. Neurobiol. Section Abstract Doc Link 9733072 Disease Relevance 0 Pain Relevance 0.18
Expression and neuropeptidergic characterization of estrogen receptors (ERalpha and ERbeta) throughout the rat brain: anatomical evidence of distinct roles of each subtype.
Gene_expression (Expression) of ERbeta in brain associated with neuropeptide
8) Confidence 0.56 Published 1998 Journal J. Neurobiol. Section Title Doc Link 9733072 Disease Relevance 0 Pain Relevance 0.21
The GPR30 agonist, but not the ERbeta agonist, rapidly restored VH.
Gene_expression (agonist) of ERbeta
9) Confidence 0.54 Published 2009 Journal Gastroenterology Section Body Doc Link 19344720 Disease Relevance 0.12 Pain Relevance 0
Both ER types were expressed in numerous sensory neurons of either upper lumbar (L1/L2) or lower lumbar/sacral (L6/S1) ganglia and there was almost complete coexpression of ERalpha and ERbeta.
Gene_expression (coexpression) of ERbeta in sensory neurons
10) Confidence 0.52 Published 2003 Journal Auton Neurosci Section Abstract Doc Link 12798205 Disease Relevance 0.29 Pain Relevance 0.41
By contrast, the coexpression between the prepro-orphanin FQ and ERbeta mRNAs was less striking in the SON.
Gene_expression (coexpression) of ERbeta associated with orphanin
11) Confidence 0.50 Published 2003 Journal Anat. Embryol. Section Abstract Doc Link 12690447 Disease Relevance 0 Pain Relevance 0.58
E2 on behavioral response following OBX may involve different mechanisms and pathways: i) membrane receptor, such as intracellular estrogen receptors (ERs).Indeed, the studies performed by Frye’s group concluded that estradiol antianxiety and antidepressive effects may involve estrogen receptor beta (ER?)
Gene_expression (involve) of estrogen receptor beta
12) Confidence 0.50 Published 2008 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2518376 Disease Relevance 0.72 Pain Relevance 0.44
Considering that both ER-alpha and ER-beta are highly expressed in efferent ductules, we hypothesized that the DHT regulation of AQP9 could be due to the 3-beta-diol metabolite.


Gene_expression (expressed) of ER-beta in ductules
13) Confidence 0.37 Published 2006 Journal Reprod Biol Endocrinol Section Abstract Doc Link PMC1615873 Disease Relevance 0 Pain Relevance 0
The rat CL express ERalpha and ERbeta mRNAs and ER immunoreactive proteins along pregnancy, with a decline in expression occurring at parturition [15].
Gene_expression (express) of ERbeta
14) Confidence 0.34 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1236958 Disease Relevance 0.12 Pain Relevance 0
To determine whether ERalpha and ERbeta genes are expressed in the rat CL post-partum, we performed semiquantitative RT-PCR to specifically detect the ERalpha and ERbeta mRNA transcripts.
Gene_expression (expressed) of ERbeta
15) Confidence 0.34 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1236958 Disease Relevance 0.09 Pain Relevance 0
Moreover, the pregnant rat CL express estrogen receptors (ERs) alpha (ERalpha) and beta (ERbeta) under the regulation of prolactin and placental lactogens [15], and respond to estradiol, which stimulates steroidogenesis [16,17], mediates luteal cell hypertrophy by increasing protein biosynthesis [18], and synergizes the luteotropic effect of prolactin [19].
Gene_expression (express) of ERbeta in luteal cell associated with hypertrophy
16) Confidence 0.34 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1236958 Disease Relevance 0.38 Pain Relevance 0
In a third experiment, we obtained CL from rats on day 15 of pregnancy and from non-lactating rats on day 4 post-partum, and studied the expression of the messenger RNAs (mRNAs) encoding the ERalpha and ERbeta genes.


Gene_expression (expression) of ERbeta
17) Confidence 0.30 Published 2005 Journal Reprod Biol Endocrinol Section Abstract Doc Link PMC1236958 Disease Relevance 0.48 Pain Relevance 0
In schizophrenia, there is a trend for reduced LC volume, and the human LC expresses both estrogen receptor alpha (ERalpha) and estrogen receptor beta (ERbeta), the latter of which is reduced in persons committing suicide.93 One postmortem study of the LC in schizophrenia found no abnormality.94 That study was a case-control study that combined males and females, with roughly two-thirds of the groups being male, a male-to-female ratio that could have possibly veiled gender-related LC sizes.
Gene_expression (expresses) of ERbeta associated with suicidal behaviour, locus ceruleus and schizophrenia
18) Confidence 0.20 Published 2009 Journal Schizophrenia Bulletin Section Body Doc Link PMC2643957 Disease Relevance 0.88 Pain Relevance 0.38
Neonatal and pubertal exposure to BPA alters or disrupts hypothalamic ERalpha transcription in a sexually dimorphic manner.82,85 Neonatal BPA exposure of female animals causes increases of ERalpha but not ERbeta in the medial basal hypothalamus but not in the anterior pituitary.84 In males, BPA increases both ERalplha and ERbeta in the pituitary but not in the hypothalamus.84 BPA treatment causes delayed and sustained hyperprolactinemia in both sexes of offspring,84 which could explain some portion of these changes in ERs.
Neg (not) Gene_expression (causes) of ERbeta in pituitary associated with galactorrhea
19) Confidence 0.17 Published 2009 Journal Schizophrenia Bulletin Section Body Doc Link PMC2643957 Disease Relevance 0.53 Pain Relevance 0.12
Prenatal and neonatal exposure to BPA in rats causes increased LC volume in males and decreased volumes in females ultimately resulting in reversal of the sex differences normally observed in the rat LC.81 The reversal likely results from BPA's estrogenic effect on ERalpha and ERbeta that are expressed in the LC.


Gene_expression (expressed) of ERbeta associated with locus ceruleus
20) Confidence 0.15 Published 2009 Journal Schizophrenia Bulletin Section Body Doc Link PMC2643957 Disease Relevance 0.76 Pain Relevance 0.40

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