INT77398

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Context Info
Confidence 0.47
First Reported 1998
Last Reported 1998
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0
Pain Relevance 1.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (ARRB1) plasma membrane (ARRB1) nucleus (ARRB1)
transcription factor binding (ARRB1) cytoplasm (ARRB1)
ARRB1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Kappa opioid receptor 2 99.68 Very High Very High Very High
Delta opioid receptors 2 99.38 Very High Very High Very High
opioid receptor 8 96.84 Very High Very High Very High
mu opioid receptor 8 95.60 Very High Very High Very High
agonist 8 89.56 High High
Enkephalin 6 83.44 Quite High
Analgesic 2 25.00 Low Low

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Truncation of kappa and delta opioid receptors at carboxyl termini abolished inhibition of beta-arr1 on the responsiveness of both receptors.
Negative_regulation (inhibition) of beta-arr1 associated with delta opioid receptors
1) Confidence 0.47 Published 1998 Journal J. Biol. Chem. Section Abstract Doc Link 9733719 Disease Relevance 0 Pain Relevance 0.70
Removal of potential phosphorylation sites on the carboxyl terminus of kappa opioid receptor led to reduced effect of beta-arr1 on the receptor-mediated response.
Negative_regulation (effect) of beta-arr1 associated with kappa opioid receptor
2) Confidence 0.34 Published 1998 Journal J. Biol. Chem. Section Abstract Doc Link 9733719 Disease Relevance 0 Pain Relevance 0.61

General Comments

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