INT77529

Context Info Confidence 0.02 First Reported 1998 Last Reported 1998 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 2 Disease Relevance 0 Pain Relevance 0.63

cytosol (Odc1) lyase activity (Odc1) cell death (PDYN) extracellular region (PDYN) plasma membrane (PDYN)

Anatomy Link Frequency cardiomyocytes 1 thymocytes 1 PDYN (Homo sapiens) Odc1 (Rattus norvegicus)

Pain Link Frequency Relevance Heat Enkephalin 2 100.00 agonist 4 95.64 Opioid 2 94.44 opioid receptor 4 75.00 antagonist 4 45.28 Kappa opioid receptor 2 25.00 MU agonist 2 25.00

Disease Link Frequency Relevance Heat Bordatella Infection 2 41.92

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In particular, Leu-enkephalin, which shows preference for delta-receptors, enhanced ODC activity in both thymocytes and cardiomyocytes, whereas the effect of U-50488H, a synthetic kappa-selective agonist, was cell-specific.

Leu-enkephalin Positive_regulation (enhanced) of ODC in cardiomyocytes associated with agonist and enkephalin

1) Confidence 0.02 Published 1998 Journal Mol. Cell. Biochem. Section Abstract Doc Link 9746211 Disease Relevance 0 Pain Relevance 0.32

In particular, Leu-enkephalin, which shows preference for delta-receptors, enhanced ODC activity in both thymocytes and cardiomyocytes, whereas the effect of U-50488H, a synthetic kappa-selective agonist, was cell-specific.

Leu-enkephalin Positive_regulation (enhanced) of ODC in thymocytes associated with agonist and enkephalin

2) Confidence 0.01 Published 1998 Journal Mol. Cell. Biochem. Section Abstract Doc Link 9746211 Disease Relevance 0 Pain Relevance 0.32

General Comments

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