INT77793

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Context Info
Confidence 0.70
First Reported 1998
Last Reported 2011
Negated 2
Speculated 1
Reported most in Abstract
Documents 54
Total Number 55
Disease Relevance 23.76
Pain Relevance 25.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Gdnf) extracellular space (Gdnf) extracellular region (Gdnf)
Anatomy Link Frequency
neurons 7
sensory neurons 3
cortex 2
spinal cord 2
nociceptors 2
Gdnf (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Nerve growth factor 746 100.00 Very High Very High Very High
fluoxetine 24 100.00 Very High Very High Very High
Endep 17 100.00 Very High Very High Very High
spinal dorsal horn 3 100.00 Very High Very High Very High
Antinociceptive 1 99.88 Very High Very High Very High
Calcitonin gene-related peptide 672 99.84 Very High Very High Very High
qutenza 451 99.84 Very High Very High Very High
Inflammation 154 99.84 Very High Very High Very High
antidepressant 61 99.84 Very High Very High Very High
Eae 11 99.72 Very High Very High Very High
Disease Link Frequency Relevance Heat
Injury 399 100.00 Very High Very High Very High
INFLAMMATION 140 99.84 Very High Very High Very High
Ganglion Cysts 573 99.62 Very High Very High Very High
Pain 170 99.42 Very High Very High Very High
Hyperalgesia 191 99.12 Very High Very High Very High
Convulsion 22 98.96 Very High Very High Very High
Spinal Cord Injury 84 98.92 Very High Very High Very High
Experimental Autoimmune Neuritis 18 98.56 Very High Very High Very High
Cv Unclassified Under Development 11 98.28 Very High Very High Very High
Neuropathic Pain 88 98.16 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Pretreatment with D3 significantly increased GDNF levels in the cortex.
Positive_regulation (increased) of GDNF in cortex
1) Confidence 0.70 Published 2000 Journal Neuropharmacology Section Abstract Doc Link 10699453 Disease Relevance 0.48 Pain Relevance 0.12
The enhanced and prolonged induction of GDNF by antidepressants could promote neuronal survival, and protect neurons from the damaging effects of stress.
Positive_regulation (induction) of GDNF in neurons associated with stress and antidepressant
2) Confidence 0.68 Published 2001 Journal J. Neurochem. Section Abstract Doc Link 11595754 Disease Relevance 0.23 Pain Relevance 0.56
The results showed that both the protein and mRNA levels of GDNF and GFRalpha-1 were significantly increased after CCI, while the thermal hyperalgesia of neuropathic pain rats could be significantly aggravated by antisense ODN treatment, but not by normal saline (NS) or mismatch ODN treatment.
Positive_regulation (increased) of GDNF associated with thermal hyperalgesia, eae and neuropathic pain
3) Confidence 0.65 Published 2006 Journal Neuropharmacology Section Abstract Doc Link 16289634 Disease Relevance 1.35 Pain Relevance 1.05
While the GDNF, GDNFR-alpha and GDNFR-beta levels in the frontal cortex were increased significantly at 1, 2 and 4 h after the injection of naloxone during morphine withdrawal.
Positive_regulation (increased) of GDNF in frontal cortex
4) Confidence 0.64 Published 2000 Journal Zhonghua Yi Xue Za Zhi Section Body Doc Link 11798749 Disease Relevance 0.15 Pain Relevance 0
RESULTS: The GDNF mRNA levels were increased, and GDNFR-alpha and GDNFR-beta mRNA levels was slightly increased in the spinal cord and brainstem during morphine dependence.
Positive_regulation (increased) of GDNF mRNA in brainstem
5) Confidence 0.64 Published 2000 Journal Zhonghua Yi Xue Za Zhi Section Body Doc Link 11798749 Disease Relevance 0.18 Pain Relevance 0
In conclusion, our data indicate that D3 reduces ischemia-induced brain damage and supports the hypothesis that this effect may be through the up-regulation of GDNF mechanisms in cortex.
Positive_regulation (up-regulation) of GDNF in cortex associated with ischemia
6) Confidence 0.61 Published 2000 Journal Neuropharmacology Section Abstract Doc Link 10699453 Disease Relevance 0.40 Pain Relevance 0.12
After dorsal root transection GDNF disappeared from the dorsal horn and after dorsal root ligation there was accumulation of GDNF only on the ganglion side of the ligation.
Positive_regulation (accumulation) of GDNF in ganglion associated with ganglion cysts and dorsal horn
7) Confidence 0.61 Published 1998 Journal Neuroreport Section Abstract Doc Link 9760141 Disease Relevance 0.19 Pain Relevance 0.37
We showed that LV vectors can be used to locally elevate levels of NGF and GDNF in the injured rat peripheral nerve and this has profound and differential effects on regenerating sensory and motor neurons.
Positive_regulation (elevate) of GDNF in motor neurons associated with nerve growth factor
8) Confidence 0.60 Published 2008 Journal Eur. J. Neurosci. Section Abstract Doc Link 18973572 Disease Relevance 0.22 Pain Relevance 0.22
These results suggest that inflammation differentially increases both NGF and GDNF, which facilitate TRPV1 expression within distinctive neurons to induce thermal hyperalgesia.
Positive_regulation (increases) of GDNF in neurons associated with inflammation and thermal hyperalgesia
9) Confidence 0.59 Published 2004 Journal Eur. J. Neurosci. Section Abstract Doc Link 15525272 Disease Relevance 0.82 Pain Relevance 0.59
Although the levels of both NGF and GDNF were increased by inflammation, NGF rapidly and transiently increased whereas GDNF increased gradually over a period of approximately one week.
Positive_regulation (increased) of GDNF associated with inflammation
10) Confidence 0.52 Published 2004 Journal Eur. J. Neurosci. Section Abstract Doc Link 15525272 Disease Relevance 0.82 Pain Relevance 0.57
The biological action of GDNF is mediated by a two-component receptor GFR?
Positive_regulation (mediated) of GDNF
11) Confidence 0.50 Published 2007 Journal Neurochem Res Section Body Doc Link PMC2270371 Disease Relevance 0.23 Pain Relevance 0.32
We demonstrated by real time PCR that levels of BDNF and GDNF mRNA were significantly higher in the motor than the sensory nerve five days after implantation into the spinal cord.
Positive_regulation (higher) of GDNF mRNA in sensory nerve associated with spinal cord
12) Confidence 0.50 Published 2008 Journal Exp. Neurol. Section Abstract Doc Link 18555993 Disease Relevance 0 Pain Relevance 0.05
These results suggested that amitriptyline-induced GDNF synthesis and release occurred at the transcriptional level, and may be regulated by MEK/MAPK signalling.
Positive_regulation (amitriptyline-induced) of GDNF associated with endep
13) Confidence 0.49 Published 2001 Journal J. Neurochem. Section Abstract Doc Link 11595754 Disease Relevance 0.14 Pain Relevance 0.61
Western blot analysis showed that the level of GDNF protein significantly increased 1.8-fold at the paralytic stage of EAN at day 12 post-immunization (PI) (p < 0.01), and its level further increased approximately 2.5-fold at day 21 PI (p < 0.001) in the sciatic nerves of EAN-affected rats compared with those of control rats, and then declined thereafter at day 28 PI.
Positive_regulation (increased) of GDNF protein in sciatic nerves associated with immunization, sciatic nerve and neuritis
14) Confidence 0.47 Published 2010 Journal J. Peripher. Nerv. Syst. Section Abstract Doc Link 20626773 Disease Relevance 1.30 Pain Relevance 1.00
This suggested that GDNF had accumulated around the transection site due to interruption of its transport within the axons.
Positive_regulation (accumulated) of GDNF
15) Confidence 0.47 Published 2007 Journal Neurochem Res Section Body Doc Link PMC2270371 Disease Relevance 0.66 Pain Relevance 0.15
In the rostral stump, the level of GDNF protein increased at 3 dpo, when compared with the control group (P < 0.05), then decreased quickly to its lowest level at 7 dpo (P < 0.05) which was less than that of the control level, and then began to increase again at 14 dpo.
Positive_regulation (increased) of GDNF
16) Confidence 0.47 Published 2007 Journal Neurochem Res Section Body Doc Link PMC2270371 Disease Relevance 0 Pain Relevance 0.06
Differently, a rapid up-regulation of GDNF was observed in the rostral stump.
Positive_regulation (regulation) of GDNF
17) Confidence 0.47 Published 2007 Journal Neurochem Res Section Body Doc Link PMC2270371 Disease Relevance 0.69 Pain Relevance 0.14
The results showed that both protein and mRNA levels of GDNF and GFRalpha-1 in the dorsal root ganglions (DRG), as well as GDNF protein in the spinal dorsal horn, were significantly increased after chronic constriction injury (CCI) of the rats' sciatic nerve and could be further enhanced by EA treatment.
Positive_regulation (increased) of GDNF in spinal associated with ganglion cysts, eae, spinal dorsal horn, injury, sciatic nerve and electroacupuncture
18) Confidence 0.44 Published 2005 Journal Neurosci. Lett. Section Abstract Doc Link 15698937 Disease Relevance 0.82 Pain Relevance 1.25
Neurotrophic factors, including glial cell line-derived neurotrophic factor (GDNF), have been known to play a role in neuroprotection in the injured peripheral nervous system (PNS).
Positive_regulation (derived) of GDNF in peripheral nervous system associated with peripheral nervous system
19) Confidence 0.44 Published 2010 Journal J. Peripher. Nerv. Syst. Section Abstract Doc Link 20626773 Disease Relevance 0.73 Pain Relevance 0.70
Changes in Glial Cell Line-derived Neurotrophic Factor Expression in the Rostral and Caudal Stumps of the Transected Adult Rat Spinal Cord

Limited information is available regarding the role of endogenous Glial cell line-derived neurotrophic factor (GDNF) in the spinal cord following transection injury.

Positive_regulation (derived) of GDNF in spinal cord associated with injury and spinal cord
20) Confidence 0.44 Published 2007 Journal Neurochem Res Section Title Doc Link PMC2270371 Disease Relevance 0.32 Pain Relevance 0.05

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