INT78032

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Context Info
Confidence 0.62
First Reported 1998
Last Reported 2010
Negated 1
Speculated 2
Reported most in Abstract
Documents 12
Total Number 13
Disease Relevance 0.72
Pain Relevance 1.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Oxtr) response to stress (Oxtr) signal transducer activity (Oxtr)
Anatomy Link Frequency
myometrium 4
endometrium 2
mammary gland 1
lamina 1
Oxtr (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 61 100.00 Very High Very High Very High
cytokine 2 100.00 Very High Very High Very High
Action potential 18 96.72 Very High Very High Very High
repetitive firing 3 82.48 Quite High
Inflammation 3 77.20 Quite High
anesthesia 9 74.48 Quite High
Dismenorea 9 69.52 Quite High
antagonist 50 59.52 Quite High
Neuropeptide 6 55.84 Quite High
Catecholamine 7 52.76 Quite High
Disease Link Frequency Relevance Heat
Increased Venous Pressure Under Development 29 98.74 Very High Very High Very High
INFLAMMATION 3 77.20 Quite High
Dysmenorrhea 6 76.80 Quite High
Shock 34 56.88 Quite High
Reprotox - General 1 1 50.00 Quite Low
Sepsis 13 49.40 Quite Low
Anxiety Disorder 8 43.88 Quite Low
Pressure Volume 2 Under Development 4 37.28 Quite Low
Hemorrhagic Shock 2 24.96 Low Low
Hypoxia 5 21.44 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Oxytocin receptor (OTR) regulation has been extensively studied in uterine myometrium and endometrium.
Regulation (regulation) of OTR in endometrium
1) Confidence 0.62 Published 1998 Journal Biol. Reprod. Section Abstract Doc Link 9780319 Disease Relevance 0 Pain Relevance 0.06
Oxytocin receptor (OTR) regulation has been extensively studied in uterine myometrium and endometrium.
Regulation (regulation) of Oxytocin receptor in endometrium
2) Confidence 0.62 Published 1998 Journal Biol. Reprod. Section Abstract Doc Link 9780319 Disease Relevance 0 Pain Relevance 0.06
Moreover, tamoxifen had no effect on the mammary gland OTR mRNA level.
Neg (no) Regulation (effect) of OTR mRNA in mammary gland
3) Confidence 0.54 Published 2001 Journal J. Mol. Endocrinol. Section Abstract Doc Link 11564602 Disease Relevance 0 Pain Relevance 0
Progesterone alone had no effect on OTR mRNA expression; however, progesterone combined with estradiol significantly inhibited the up-regulation of OTR mRNA by estradiol alone.
Regulation (regulation) of OTR mRNA
4) Confidence 0.27 Published 1998 Journal Biol. Reprod. Section Abstract Doc Link 9780319 Disease Relevance 0 Pain Relevance 0.07
Oxytocin receptor (OTR) regulation has been extensively studied in uterine myometrium and endometrium.
Regulation (regulation) of OTR in myometrium
5) Confidence 0.21 Published 1998 Journal Biol. Reprod. Section Abstract Doc Link 9780319 Disease Relevance 0 Pain Relevance 0.06
Oxytocin receptor (OTR) regulation has been extensively studied in uterine myometrium and endometrium.
Regulation (regulation) of Oxytocin receptor in myometrium
6) Confidence 0.21 Published 1998 Journal Biol. Reprod. Section Abstract Doc Link 9780319 Disease Relevance 0 Pain Relevance 0.06
Therefore, designing drugs targeting both the oxytocin receptor and selectively one specific pathway (by combining agents or addressing one particular cell type for instance) might become a major consideration in the development of the next oxytocin-based therapies.


Spec (might) Regulation (targeting) of oxytocin receptor
7) Confidence 0.18 Published 2010 Journal CNS Neuroscience & Therapeutics Section Body Doc Link PMC2972642 Disease Relevance 0 Pain Relevance 0.03
Whether vasopressin causes vasoconstriction or vasodilation depends on the vascular bed studied [46], which may, in turn, depend on the receptor density (V1R versus OTR), the model studied, the dose of vasopressin [47], and the duration of exposure to the hormone [48].
Spec (may) Regulation (depend) of OTR associated with increased venous pressure under development
8) Confidence 0.16 Published 2004 Journal Crit Care Section Body Doc Link PMC420051 Disease Relevance 0.43 Pain Relevance 0.03
In order to better understand how OT-receptor agonists could affect the firing profile of lamina II neurons, we focused our attention on the possible implication of potassium currents in this phenomenon.
Regulation (affect) of OT-receptor in lamina associated with agonist
9) Confidence 0.13 Published 2009 Journal Mol Pain Section Body Doc Link PMC2780383 Disease Relevance 0 Pain Relevance 0.47
Our objective was to examine the topology-, gestation- and labor-related changes of estrogen receptor (ER)alpha, progesterone receptor (PR), oxytocin receptor (OTR) and thrombospondin-1 (TSP1) mRNA in pregnant baboon myometrium.
Regulation (changes) of oxytocin receptor in myometrium
10) Confidence 0.11 Published 2001 Journal J. Endocrinol. Section Abstract Doc Link 11739010 Disease Relevance 0 Pain Relevance 0
Our objective was to examine the topology-, gestation- and labor-related changes of estrogen receptor (ER)alpha, progesterone receptor (PR), oxytocin receptor (OTR) and thrombospondin-1 (TSP1) mRNA in pregnant baboon myometrium.
Regulation (changes) of OTR in myometrium
11) Confidence 0.11 Published 2001 Journal J. Endocrinol. Section Abstract Doc Link 11739010 Disease Relevance 0 Pain Relevance 0
Specifically, we will consider the regulation of some of the 'labour-associated proteins', chemotactic cytokines, prostaglandins and enzymes of the prostaglandin biosynthetic pathway and the oxytocin receptor.
Regulation (regulation) of oxytocin receptor associated with cytokine
12) Confidence 0.10 Published 2004 Journal Seminars in fetal & neonatal medicine Section Abstract Doc Link 15691781 Disease Relevance 0.22 Pain Relevance 0.23
Both OTR and TRPV1 immunoreactivity were positively correlated with the severity of dysmenorrhea and found to be significant predicators for dysmenorrhea severity.
Regulation (immunoreactivity) of OTR
13) Confidence 0.07 Published 2010 Journal Am. J. Obstet. Gynecol. Section Body Doc Link 20096818 Disease Relevance 0.08 Pain Relevance 0

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