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Context Info
Confidence 0.78
First Reported 1998
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 16
Total Number 19
Disease Relevance 8.40
Pain Relevance 4.92

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Adm) extracellular region (Adm) response to stress (Adm)
cytoplasm (Adm)
Anatomy Link Frequency
dorsal root ganglion 3
eye 1
spinal cord 1
neurons 1
adipocyte 1
Adm (Mus musculus)
Pain Link Frequency Relevance Heat
Calcitonin gene-related peptide 18 99.84 Very High Very High Very High
Morphine 4 99.70 Very High Very High Very High
Spinal cord 7 99.56 Very High Very High Very High
intrathecal 3 99.26 Very High Very High Very High
spinal dorsal horn 2 98.48 Very High Very High Very High
headache 5 97.64 Very High Very High Very High
dorsal root ganglion 8 97.56 Very High Very High Very High
analgesia 1 97.56 Very High Very High Very High
Enkephalin 2 96.88 Very High Very High Very High
tolerance 4 96.36 Very High Very High Very High
Disease Link Frequency Relevance Heat
Targeted Disruption 7 99.88 Very High Very High Very High
Pneumonia 188 99.64 Very High Very High Very High
Natriuresis 28 98.80 Very High Very High Very High
Hypoxia 12 98.44 Very High Very High Very High
Vomiting 5 98.08 Very High Very High Very High
Headache 5 97.64 Very High Very High Very High
Hypotension 2 97.36 Very High Very High Very High
Ganglion Cysts 10 97.08 Very High Very High Very High
Lower Respiratory Tract Infection 120 96.84 Very High Very High Very High
Dizziness 4 96.40 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, the spinal cord of adm knockout mice expressed higher levels of the AM receptor components, suggesting a compensation attempt to deal with the lack of afferent AM signaling.
Gene_expression (expressed) of AM receptor in spinal cord associated with targeted disruption and spinal cord
1) Confidence 0.78 Published 2010 Journal Endocrinology Section Abstract Doc Link 20858768 Disease Relevance 0.68 Pain Relevance 0.88
Double immunofluorescence in wild-type (WT) animals shows that AM immunoreactivity is found in calcitonin gene-related peptide-positive neurons of the dorsal root ganglia but not in neurons that bind isolectin B4.
Neg (not) Gene_expression (found) of AM in neurons associated with calcitonin gene-related peptide
2) Confidence 0.59 Published 2010 Journal Endocrinology Section Abstract Doc Link 20858768 Disease Relevance 0.57 Pain Relevance 0.83
The AM-m/AM-T ratio decreased during CPB, suggesting that production of the intermediate form of AM, AM-glycine, is more than that of AM-m.
Gene_expression (production) of AM
3) Confidence 0.50 Published 2003 Journal Anesth. Analg. Section Abstract Doc Link 12933380 Disease Relevance 0 Pain Relevance 0.09
These data suggest that the hepatosplanchnic circulation is an important source of AM-m during CPB.
Gene_expression (source) of AM
4) Confidence 0.50 Published 2003 Journal Anesth. Analg. Section Abstract Doc Link 12933380 Disease Relevance 0 Pain Relevance 0.07
The AM-m/AM-T ratio decreased during CPB, suggesting that production of the intermediate form of AM, AM-glycine, is more than that of AM-m.
Gene_expression (production) of AM
5) Confidence 0.50 Published 2003 Journal Anesth. Analg. Section Abstract Doc Link 12933380 Disease Relevance 0 Pain Relevance 0.09
Key messages

• The simultaneous measurement of different prohormones each reflecting distinct pathophysiological pathways could enhance risk stratification in patients with CAP. • The precursor levels of adrenomedullin (ADM), endothelin-1 (ET1), atrial-natriuretic peptide (ANP), anti-diuretic hormone (copeptin), and procalcitonin (PCT) on admission and during follow up, showed all high prognostic accuracies for mortality and serious complications. • For the prediction of serious complications, ProADM and proET1 alone had stronger discriminatory power than the PSI or CURB65 score or any components of these risk scores.

Gene_expression (levels) of ADM associated with natriuresis and pneumonia
6) Confidence 0.46 Published 2010 Journal Crit Care Section Body Doc Link PMC2911752 Disease Relevance 0.70 Pain Relevance 0
Key messages

• The simultaneous measurement of different prohormones each reflecting distinct pathophysiological pathways could enhance risk stratification in patients with CAP. • The precursor levels of adrenomedullin (ADM), endothelin-1 (ET1), atrial-natriuretic peptide (ANP), anti-diuretic hormone (copeptin), and procalcitonin (PCT) on admission and during follow up, showed all high prognostic accuracies for mortality and serious complications. • For the prediction of serious complications, ProADM and proET1 alone had stronger discriminatory power than the PSI or CURB65 score or any components of these risk scores.

Gene_expression (levels) of adrenomedullin associated with natriuresis and pneumonia
7) Confidence 0.46 Published 2010 Journal Crit Care Section Body Doc Link PMC2911752 Disease Relevance 0.70 Pain Relevance 0
We assessed clinical parameters and five biomarkers, the precursor levels of adrenomedullin (ADM), endothelin-1 (ET1), atrial-natriuretic peptide (ANP), anti-diuretic hormone (copeptin), and procalcitonin in patients with LRTI and CAP enrolled in the multicenter ProHOSP study.
Gene_expression (levels) of adrenomedullin associated with natriuresis, pneumonia and lower respiratory tract infection
8) Confidence 0.46 Published 2010 Journal Crit Care Section Abstract Doc Link PMC2911752 Disease Relevance 1.12 Pain Relevance 0
We assessed clinical parameters and five biomarkers, the precursor levels of adrenomedullin (ADM), endothelin-1 (ET1), atrial-natriuretic peptide (ANP), anti-diuretic hormone (copeptin), and procalcitonin in patients with LRTI and CAP enrolled in the multicenter ProHOSP study.
Gene_expression (levels) of ADM associated with natriuresis, pneumonia and lower respiratory tract infection
9) Confidence 0.46 Published 2010 Journal Crit Care Section Abstract Doc Link PMC2911752 Disease Relevance 1.12 Pain Relevance 0
MEFs (Table S3) could also be found, through literature searches, to exhibit expression positively correlated with adipocyte differentiation, including Adm, Lpar1, Osmr, and Ptx3 [69],[71],[72].
Gene_expression (expression) of Adm in adipocyte
10) Confidence 0.44 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2730539 Disease Relevance 0.16 Pain Relevance 0.03
Our data show that AM expression regulation constitutes a cortical response to hypobaria, suggesting that AM modulation may provide new therapeutic avenues to prevent and/or treat the symptoms produced by hypobaria.
Gene_expression (expression) of AM
11) Confidence 0.12 Published 2008 Journal Brain Pathol. Section Abstract Doc Link 18371176 Disease Relevance 0.43 Pain Relevance 0.17
There were many AM-LI positive cells in the dorsal root ganglia, where AM mRNA was detected.
Gene_expression (detected) of AM mRNA in dorsal root ganglia
12) Confidence 0.11 Published 2004 Journal J. Pharmacol. Sci. Section Abstract Doc Link 15599094 Disease Relevance 0.15 Pain Relevance 0.39
Real-time PCR quantification of AM mRNA and Western blotting confirmed the up-regulation of AM expression following hypobaria.
Gene_expression (expression) of AM
13) Confidence 0.08 Published 2008 Journal Brain Pathol. Section Abstract Doc Link 18371176 Disease Relevance 0.46 Pain Relevance 0.18
Here we report the changes in adrenomedullin (AM) expression observed in rats exposed to hypobaric hypoxia and different times of reoxygenation.
Gene_expression (expression) of AM associated with hypoxia
14) Confidence 0.08 Published 2008 Journal Brain Pathol. Section Abstract Doc Link 18371176 Disease Relevance 0.66 Pain Relevance 0.22
In addition, hypobaria modulates alternative splicing of the AM gene resulting in a higher production of AM.
Gene_expression (production) of AM
15) Confidence 0.08 Published 2008 Journal Brain Pathol. Section Abstract Doc Link 18371176 Disease Relevance 0.43 Pain Relevance 0.17
Adrenomedullin (AM), a 52-amino acid smooth muscle-relaxing polypeptide, is produced in several tissues, including the eye [16].
Gene_expression (produced) of Adrenomedullin in eye
16) Confidence 0.07 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2773738 Disease Relevance 0 Pain Relevance 0
Intravenous injection of rat PAMP (rPAMP) (10, 20 and 50 nmol/kg) and rat AM (rAM) (0.3, 1.0 and 3.0 nmol/kg) similarly elicited dose-related hypotension accompanied by increases in HR and RSNA.
Gene_expression (injection) of AM associated with hypotension
17) Confidence 0.07 Published 1998 Journal Regul. Pept. Section Abstract Doc Link 9809809 Disease Relevance 0.18 Pain Relevance 0.09
Injection of CFA, but not of saline, in the unilateral hindpaw produced an increase in the expression of AM-like immunoreactivity (AM-IR) in laminae I-II of the spinal cord as well as in small- and medium-sized dorsal root ganglion (DRG) neurons at 48 h.
Gene_expression (expression) of AM in dorsal root ganglion associated with ganglion cysts, dorsal root ganglion and spinal cord
18) Confidence 0.01 Published 2009 Journal Pain Section Abstract Doc Link 19683388 Disease Relevance 0.64 Pain Relevance 0.58
Repetitive intrathecal injection of morphine increased the expression of AM-like immunoreactivity (AM-IR) in the spinal dorsal horn and dorsal root ganglion (DRG) neurons.
Gene_expression (expression) of AM in DRG associated with ganglion cysts, dorsal root ganglion, spinal dorsal horn, morphine and intrathecal
19) Confidence 0.01 Published 2010 Journal J. Neurosci. Section Abstract Doc Link 20844145 Disease Relevance 0.40 Pain Relevance 1.12

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