INT7845

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Context Info
Confidence 0.62
First Reported 1982
Last Reported 2010
Negated 4
Speculated 9
Reported most in Abstract
Documents 44
Total Number 52
Disease Relevance 4.54
Pain Relevance 30.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (OPRK1) signal transducer activity (OPRK1)
Anatomy Link Frequency
brain 6
embryonic kidney 3
ileum 1
plasma 1
colon 1
OPRK1 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 139 100.00 Very High Very High Very High
Kappa opioid receptor 125 100.00 Very High Very High Very High
Opioid 57 100.00 Very High Very High Very High
antagonist 49 100.00 Very High Very High Very High
opioid receptor 49 100.00 Very High Very High Very High
narcan 37 100.00 Very High Very High Very High
Dynorphin 34 100.00 Very High Very High Very High
Enkephalin 30 100.00 Very High Very High Very High
Analgesic 21 100.00 Very High Very High Very High
opiate 20 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Opiate Addiction 6 99.58 Very High Very High Very High
Alcohol Addiction 2 99.28 Very High Very High Very High
Overdose 5 98.92 Very High Very High Very High
Nociception 7 98.60 Very High Very High Very High
Epilepsy 2 98.28 Very High Very High Very High
Disease 6 97.80 Very High Very High Very High
Convulsion 4 97.60 Very High Very High Very High
Diuresis 2 97.32 Very High Very High Very High
Pain 3 97.28 Very High Very High Very High
Cognitive Disorder 3 96.40 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Effects of salvinorin A, a kappa-opioid hallucinogen, on a neuroendocrine biomarker assay in nonhuman primates with high kappa-receptor homology to humans.
Regulation (Effects) of kappa-opioid hallucinogen associated with opioid
1) Confidence 0.62 Published 2007 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 17060493 Disease Relevance 0 Pain Relevance 0.38
Ligand-induced regulation of the rat kappa-opioid receptor (rKOR) was investigated in human embryonic kidney 293 cells stably expressing the FLAG-tagged rKOR.
Regulation (regulation) of rKOR in embryonic kidney associated with kappa opioid receptor
2) Confidence 0.60 Published 2007 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 17720886 Disease Relevance 0 Pain Relevance 0.20
Naltrexone did not alter rKOR mRNA levels or translational efficiency, and rKOR up-regulation was not inhibited by cycloheximide.
Neg (not) Regulation (alter) of rKOR
3) Confidence 0.60 Published 2007 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 17720886 Disease Relevance 0 Pain Relevance 0.34
This study compares the regulation of basal signaling of MOR, delta-(DOR), and kappa-(KOR) opioid receptors after pretreatment with morphine or receptor-selective agonists, in transfected human embryonic kidney 293 cell membranes.
Regulation (regulation) of KOR in embryonic kidney associated with agonist, opioid receptor and morphine
4) Confidence 0.60 Published 2007 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 17267582 Disease Relevance 0 Pain Relevance 1.36
Ligand-induced regulation of the rat kappa-opioid receptor (rKOR) was investigated in human embryonic kidney 293 cells stably expressing the FLAG-tagged rKOR.
Regulation (regulation) of kappa-opioid receptor in embryonic kidney associated with kappa opioid receptor
5) Confidence 0.52 Published 2007 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 17720886 Disease Relevance 0 Pain Relevance 0.20
The results indicate that memory formation for one-trial peck-avoidance training may be modulated by kappa opioid receptor activity.
Regulation (modulated) of kappa opioid receptor associated with kappa opioid receptor
6) Confidence 0.44 Published 1992 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 1357708 Disease Relevance 0.19 Pain Relevance 0.35
Kappa opiate receptor agonists: effects on behavior and on brain function and structure in rhesus monkeys.
Regulation (effects) of Kappa opiate receptor in brain associated with narcan, agonist and opiate
7) Confidence 0.44 Published 1984 Journal Biol. Psychiatry Section Title Doc Link 6089918 Disease Relevance 0.27 Pain Relevance 0.32
Differential agonist regulation of the human kappa-opioid receptor.
Regulation (regulation) of kappa-opioid receptor associated with kappa opioid receptor and agonist
8) Confidence 0.44 Published 1997 Journal J. Neurochem. Section Title Doc Link 9109509 Disease Relevance 0.23 Pain Relevance 0.96
Taken together, these results demonstrate that the human kappa receptor is differentially regulated by selective and nonselective opioid agonists, with selective agonists able to desensitize the receptor.
Regulation (regulated) of kappa receptor associated with mu agonist and agonist
9) Confidence 0.44 Published 1997 Journal J. Neurochem. Section Abstract Doc Link 9109509 Disease Relevance 0.12 Pain Relevance 0.64
We examined the effect of micro, delta, and kappa opioid receptor agonists and antagonists on feeding, mass changes and activity in the cockroach, Periplaneta americana.
Spec (examined) Regulation (effect) of kappa opioid receptor associated with antagonist, agonist and kappa opioid receptor
10) Confidence 0.44 Published 2010 Journal Comp. Biochem. Physiol. C Toxicol. Pharmacol. Section Abstract Doc Link 20005975 Disease Relevance 0 Pain Relevance 0.54
Effect of the kappa-opioid receptor agonist, U69593, on reinstatement of extinguished amphetamine self-administration behavior.
Regulation (Effect) of kappa-opioid receptor associated with analgesic, agonist and kappa opioid receptor
11) Confidence 0.44 Published 2001 Journal Pharmacol. Biochem. Behav. Section Title Doc Link 11526958 Disease Relevance 0 Pain Relevance 0.63
Experiments determined the effects of two relatively selective kappa opioid receptor agonists, ICI 204 448 (ICI), which has limited ability to penetrate the blood-brain barrier, and spiradoline mesylate on: (1) in vivo parameters, intraocular pressure (IOP) and pupil diameter (PD); and (2) in vitro parameters, neurotransmitter release and cAMP accumulation, in the ciliary body.
Spec (determined) Regulation (effects) of kappa opioid receptor in brain associated with neurotransmitter, agonist, kappa opioid receptor and ocular hypertension
12) Confidence 0.43 Published 2001 Journal Exp. Eye Res. Section Abstract Doc Link 11446767 Disease Relevance 0.19 Pain Relevance 0.39
We have studied the effects of mu- and kappa-opioid receptor blockade on endogenous acetylcholine and noradrenaline overflow from the myenteric plexus of the guinea-pig isolated colon.
Regulation (effects) of kappa-opioid receptor in colon associated with noradrenaline and kappa opioid receptor
13) Confidence 0.38 Published 1995 Journal Neurosci. Lett. Section Abstract Doc Link 7478234 Disease Relevance 0 Pain Relevance 0.42
[Analgesic effect of kappa-opioid receptor agonist].
Regulation (effect) of kappa-opioid receptor associated with analgesic, agonist and kappa opioid receptor
14) Confidence 0.36 Published 2001 Journal Nippon Rinsho Section Title Doc Link 11554036 Disease Relevance 0.24 Pain Relevance 1.01
Effects of the kappa opioid agonist U50,488 and the kappa opioid antagonist nor-binaltorphimine on choice between cocaine and food in rhesus monkeys.
Regulation (Effects) of kappa opioid associated with mu agonist, antagonist, opioid and cocaine
15) Confidence 0.34 Published 2004 Journal Psychopharmacology (Berl.) Section Title Doc Link 15112031 Disease Relevance 0 Pain Relevance 0.49
Ligands regulate cell surface level of the human kappa opioid receptor by activation-induced down-regulation and pharmacological chaperone-mediated enhancement: differential effects of nonpeptide and peptide agonists.
Regulation (regulate) of kappa opioid receptor associated with narcan, agonist and kappa opioid receptor
16) Confidence 0.31 Published 2006 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 16882876 Disease Relevance 0 Pain Relevance 0.64
The effects of two general anesthetics, nitrous oxide and halothane, and oxygen on mu and kappa opioid receptor subtypes from guinea-pig brain were investigated. mu receptor binding was defined using [3H]dihydromorphine as the ligand.
Regulation (effects) of kappa opioid receptor in brain associated with kappa opioid receptor and halothane
17) Confidence 0.30 Published 1989 Journal Anesthesiology Section Abstract Doc Link 2564264 Disease Relevance 0 Pain Relevance 0.27
We observed the same pattern of changes for prodynorphin, proenkephalin, and the kappa opioid receptor as after 72 h exposure to EtOH.
Regulation (changes) of kappa opioid receptor associated with kappa opioid receptor
18) Confidence 0.30 Published 2008 Journal FASEB J. Section Abstract Doc Link 17934066 Disease Relevance 0.15 Pain Relevance 0.57
A comparison of the affinities obtained in human cloned kappa-receptor with the correspondent one obtained in native guinea pig kappa-receptor suggests that the human cloned kappa-receptor is less effective in discriminating the substitution pattern than the native guinea pig kappa-receptor.
Regulation (effective) of kappa-receptor
19) Confidence 0.27 Published 2003 Journal J. Med. Chem. Section Abstract Doc Link 12930147 Disease Relevance 0 Pain Relevance 0.27
Dynorphin(1-13), U69,593 [(5alpha,7alpha,8beta)-(+)-N-methyl-N-(7-[1-pyrrolidinyl]-1-oxaspiro[4,5]dec-8-yl)benzeneacetamide], or salvinorin A [2S,4aR,6aR,7R,9S,10aS, 10bR)-9-(acetyloxy)-2-(3-furanyl)dodecahydro-6a,10b-dimethyl-4,10-dioxo-2H-naphtho[2,1c]pyran-7-carboxylic acid methyl ester] treatment did not alter the level of immunoreactive rKOR protein, whereas etorphine, cyclazocine, naloxone, and naloxone methiodide increased the 52-kDa and decreased the 42-kDa rKOR bands.
Neg (not) Regulation (alter) of rKOR protein in bands associated with dynorphin, narcan and immobilon
20) Confidence 0.26 Published 2007 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 17720886 Disease Relevance 0 Pain Relevance 0.34

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