INT78478

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Context Info
Confidence 0.21
First Reported 1996
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 1.75
Pain Relevance 0.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (TOP1) nuclear chromosome (TOP1) nucleolus (TOP1)
nucleus (TOP1) DNA binding (TOP1) cytoplasm (TOP1)
Anatomy Link Frequency
apoptotic cell 1
TOP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
palliative 1 63.48 Quite High
headache 1 25.00 Low Low
vincristine 48 6.88 Low Low
Central nervous system 1 5.00 Very Low Very Low Very Low
tetrodotoxin 1 5.00 Very Low Very Low Very Low
Lasting pain 1 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Ziconotide 1 5.00 Very Low Very Low Very Low
antagonist 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Death 11 99.12 Very High Very High Very High
Apoptosis 3 98.90 Very High Very High Very High
Disease 24 96.60 Very High Very High Very High
Cancer 15 96.52 Very High Very High Very High
Recurrence 17 95.72 Very High Very High Very High
Small Cell Lung Cancer 30 84.56 Quite High
Toxicity 7 69.68 Quite High
Lung Cancer 10 68.60 Quite High
Metastasis 11 67.72 Quite High
Solid Tumor 2 59.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Topotecan, a semisynthetic water-soluble analogue of camptothecin, inhibits human topoisomerase I (topo I).
Negative_regulation (inhibits) of topoisomerase I
1) Confidence 0.21 Published 1996 Journal Clin. Cancer Res. Section Abstract Doc Link 9816325 Disease Relevance 0.18 Pain Relevance 0
Topotecan (Hycamtin, GlaxoSmithKline) acts by inhibiting topoisomerase I, an enzyme that is required for DNA replication, leading to cell death.
Negative_regulation (inhibiting) of topoisomerase I associated with death
2) Confidence 0.12 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2931489 Disease Relevance 1.11 Pain Relevance 0.06
They induce apoptotic cell death through multi-target mechanisms, including inhibition of topoisomerase I, interaction with DNA and direct effects on mitochondria.
Negative_regulation (inhibition) of topoisomerase I in apoptotic cell associated with apoptosis and death
3) Confidence 0.02 Published 2008 Journal Mar Drugs Section Abstract Doc Link PMC2630805 Disease Relevance 0.45 Pain Relevance 0

General Comments

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