INT7853

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Context Info
Confidence 0.42
First Reported 1990
Last Reported 2000
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 0.81
Pain Relevance 2.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Cck) extracellular region (Cck)
Anatomy Link Frequency
neurons 2
brain 2
ventral 2
Cck (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Cholecystokinin 22 100.00 Very High Very High Very High
antagonist 8 100.00 Very High Very High Very High
gABA 7 100.00 Very High Very High Very High
Pain 2 98.40 Very High Very High Very High
Chronic pancreatitis 2 97.32 Very High Very High Very High
Somatostatin 8 91.12 High High
tetrodotoxin 2 89.88 High High
Endogenous opioid 2 88.76 High High
Nucleus accumbens 3 88.56 High High
halothane 1 75.40 Quite High
Disease Link Frequency Relevance Heat
Pain 2 98.40 Very High Very High Very High
Pancreatitis 6 97.32 Very High Very High Very High
Stress 1 88.84 High High
Pancreatic Fistula 1 77.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Blockade of type A CCK receptors using the selective type A receptor antagonist MK-329 completely reversed the inhibitory effect produced by a maximal dose (4 nmol.kg-1.h-1) of CCK.
Negative_regulation (reversed) of Negative_regulation (Blockade) of CCK associated with antagonist and cholecystokinin
1) Confidence 0.42 Published 1992 Journal Am. J. Physiol. Section Abstract Doc Link 1357976 Disease Relevance 0 Pain Relevance 0.87
CCK8 blocked the liver DNA effect of beta-endorphin via actions within the brain, as subcutaneous administration of CCK8 was ineffective.
Negative_regulation (ineffective) of Negative_regulation (administration) of CCK8 in brain
2) Confidence 0.42 Published 1994 Journal Brain Res. Section Abstract Doc Link 7834370 Disease Relevance 0 Pain Relevance 0.31
This inhibitory effect is mediated via nonadrenergic, noncholinergic inhibitory neurons and is similar to the inhibitory effect of cholecystokinin on the sphincter of Oddi.
Negative_regulation (inhibitory) of Negative_regulation (effect) of cholecystokinin in neurons associated with cholecystokinin
3) Confidence 0.41 Published 1990 Journal Dig. Dis. Sci. Section Abstract Doc Link 2344805 Disease Relevance 0 Pain Relevance 0.14
The CCK-8S (1000 nM) induced decrease in ventral pallidal dialysate GABA levels was abolished when PD134308, TTX and bicuculline, but not L-364,718, were included into the perfusion medium of the accumbens probe.
Negative_regulation (abolished) of Negative_regulation (decrease) of CCK-8S in ventral associated with gaba
4) Confidence 0.37 Published 2000 Journal Life Sci. Section Abstract Doc Link 11197746 Disease Relevance 0 Pain Relevance 0.67
Because increased pancreatic stimulation due to loss of feedback inhibition of CCK has been proposed to contribute to the pain of some patients with chronic pancreatitis, CCK receptor antagonists could also be of benefit in this setting.
Negative_regulation (loss) of Negative_regulation (inhibition) of CCK associated with pain, antagonist, chronic pancreatitis and cholecystokinin
5) Confidence 0.08 Published 1992 Journal The Yale Journal of Biology and Medicine Section Abstract Doc Link PMC2589733 Disease Relevance 0.81 Pain Relevance 0.70

General Comments

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