INT78571

From wiki-pain
Revision as of 18:27, 24 September 2012 by Daniel (Talk | contribs)

(diff) ← Older revision | Latest revision (diff) | Newer revision → (diff)
Jump to: navigation, search
Context Info
Confidence 0.69
First Reported 1998
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 35
Total Number 35
Disease Relevance 11.81
Pain Relevance 22.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Grm5) cytoplasm (Grm5) signal transducer activity (Grm5)
Anatomy Link Frequency
spinal cord 5
neurons 5
spinal 2
spinal nerve 1
spike 1
Grm5 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Glutamate 137 100.00 Very High Very High Very High
Kinase C 75 100.00 Very High Very High Very High
Spinal cord 61 100.00 Very High Very High Very High
Glutamate receptor 57 100.00 Very High Very High Very High
dorsal root ganglion 1 100.00 Very High Very High Very High
amygdala 92 99.96 Very High Very High Very High
antinociception 12 99.92 Very High Very High Very High
Pyramidal cell 21 99.88 Very High Very High Very High
nMDA receptor 43 99.80 Very High Very High Very High
Endocannabinoid 6 99.80 Very High Very High Very High
Disease Link Frequency Relevance Heat
Ganglion Cysts 9 100.00 Very High Very High Very High
Diabetes Mellitus 8 99.84 Very High Very High Very High
Hypersensitivity 12 99.64 Very High Very High Very High
INFLAMMATION 17 99.40 Very High Very High Very High
Arthritis 67 99.18 Very High Very High Very High
Nociception 44 99.12 Very High Very High Very High
Nervous System Injury 6 98.96 Very High Very High Very High
Injury 12 98.72 Very High Very High Very High
Depression 10 98.52 Very High Very High Very High
Pain 90 97.72 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results demonstrate that the activation of mGluR5 and in turn triggering a PLC/PKC-dependent signaling cascade may contribute to the induction of LTP of primary afferent synaptic transmission in the superficial layer of trigeminal caudal nucleus of juvenile rats.
Positive_regulation (activation) of mGluR5 in juvenile associated with kinase c and long-term potentiation
1) Confidence 0.69 Published 2005 Journal Pain Section Abstract Doc Link 15777867 Disease Relevance 0.10 Pain Relevance 0.80
Activation of mGluR5 may mobilize the release of intracellular Ca(2+) and activate PKC, leading to morphine-induced antinociception suppression.
Positive_regulation (Activation) of mGluR5 associated with antinociception and morphine
2) Confidence 0.69 Published 2007 Journal Neurosci. Lett. Section Abstract Doc Link 17512115 Disease Relevance 0 Pain Relevance 1.99
As the activation of NMDA receptor after chronic morphine administration has been verified, we suppose there is an enhanced activation of mGluR5 during the development of tolerance to morphine-induced antinociception.
Positive_regulation (activation) of mGluR5 associated with antinociception, nmda receptor, tolerance and morphine
3) Confidence 0.69 Published 2007 Journal Neurosci. Lett. Section Abstract Doc Link 17512115 Disease Relevance 0 Pain Relevance 1.99
Synaptic plasticity in the CeA was accompanied by increased presynaptic mGluR1 function and upregulation of mGluR1 and mGluR5.
Positive_regulation (upregulation) of mGluR5 in CeA associated with amygdala
4) Confidence 0.68 Published 2003 Journal J. Neurosci. Section Abstract Doc Link 12514201 Disease Relevance 0.97 Pain Relevance 1.32
A selective mGluR1 antagonist reduced transmission in CeA neurons from arthritic animals but not in control neurons, and increased levels of mGluR1 and mGluR5 protein were measured in the CeA of arthritic rats compared with controls.
Positive_regulation (increased) of mGluR5 protein in neurons associated with antagonist, amygdala and arthritis
5) Confidence 0.68 Published 2003 Journal J. Neurosci. Section Abstract Doc Link 12514201 Disease Relevance 0.84 Pain Relevance 1.16
These findings support the idea that the increased levels of mGluR5 in the spinal cord may be, at least in part, involved in the induction of ethanol-dependent neuropathic pain-like state.
Positive_regulation (increased) of mGluR5 in spinal cord associated with neuropathic pain and spinal cord
6) Confidence 0.67 Published 2006 Journal Neurosci. Lett. Section Abstract Doc Link 17081689 Disease Relevance 0.39 Pain Relevance 0.54
Furthermore, immunoblot analysis revealed that the protein level of mGluR5 was clearly increased following chronic ethanol consumption.
Positive_regulation (increased) of mGluR5
7) Confidence 0.67 Published 2006 Journal Neurosci. Lett. Section Abstract Doc Link 17081689 Disease Relevance 0.31 Pain Relevance 0.54
Under these conditions, an immunohistochemical study showed an increase in metabotropic glutamate receptor 5 (mGluR5) immunoreactivity in the superficial spinal dorsal horn of chronic ethanol-fed rats.
Positive_regulation (increase) of mGluR5 in dorsal horn associated with spinal dorsal horn and glutamate receptor
8) Confidence 0.67 Published 2006 Journal Neurosci. Lett. Section Abstract Doc Link 17081689 Disease Relevance 0.33 Pain Relevance 0.55
We hypothesize that activation of mGluR5 and NMDA receptors occurs after the appearance of antinociceptive tolerance to morphine.
Positive_regulation (activation) of mGluR5 associated with nmda receptor, tolerance, antinociceptive and morphine
9) Confidence 0.67 Published 2008 Journal Neurosci. Lett. Section Abstract Doc Link 18395342 Disease Relevance 0 Pain Relevance 1.48
Compared to untreated rats, CFA-treated rats had a significant increase in the number of plasma membrane-associated mGluR5 immunogold-labeled particles in lamina I-II neurons of the spinal cord.
Positive_regulation (increase) of mGluR5 in neurons associated with spinal cord
10) Confidence 0.60 Published 2007 Journal J. Comp. Neurol. Section Abstract Doc Link 17912745 Disease Relevance 0.40 Pain Relevance 0.70
Moreover, activation of mGluR5 participates in the mediation of D(2) antagonist-induced PPE expression.
Positive_regulation (activation) of mGluR5 associated with antagonist
11) Confidence 0.55 Published 2003 Journal Synapse Section Abstract Doc Link 12539198 Disease Relevance 0 Pain Relevance 0.20
Metabotropic glutamate receptor 5 (mGlu5) negative allosteric modulators (NAMs) have previously been implicated in a number of pathophysiological conditions, based on preclinical, and to some extent clinical, proof of concept for migraine, gastroesophageal reflux disease, Parkinson's disease and anxiety.
Positive_regulation (Metabotropic) of mGlu5 associated with migraine, glutamate receptor, anxiety disorder, gastroesophageal reflux disease and disease
12) Confidence 0.50 Published 2010 Journal Expert Opin Ther Pat Section Abstract Doc Link 20180623 Disease Relevance 0.36 Pain Relevance 0.22
Electrophysiological and behavioral studies point to a role of group I metabotropic glutamate receptors (mGluR1 and mGluR5) in mediating spinal nociceptive responses in rats.
Positive_regulation (role) of mGluR5 in spinal associated with nociception and glutamate receptor
13) Confidence 0.49 Published 1998 Journal J. Neurosci. Section Abstract Doc Link 9822771 Disease Relevance 0.17 Pain Relevance 0.40
In layer 5 neocortical pyramidal neurons, the activation of type 5 metabotropic glutamate receptors (mGluR5) leads to a long-lasting reduction of the apamin-sensitive IAHP and the mAHP, resulting in the LTP of intrinsic excitability and increased spike timing precision [93].
Positive_regulation (activation) of mGluR5 in spike associated with glutamate receptor, pyramidal cell and long-term potentiation
14) Confidence 0.45 Published 2008 Journal Cell Mol Life Sci Section Body Doc Link PMC2798969 Disease Relevance 0.05 Pain Relevance 0.17
The results imply that responding for nicotine depends upon the stimulation of mGluR5 receptors within the brain, although higher doses of the drug also exert other effects which could be implicated in the psychopharmacological responses to MPEP.
Positive_regulation (stimulation) of mGluR5 in brain associated with nicotine
15) Confidence 0.45 Published 2010 Journal Psychopharmacology (Berl) Section Body Doc Link PMC2885299 Disease Relevance 0 Pain Relevance 0.20
If the hypothesis is true, it suggests that stimulation of mGluR5 receptors may also play a significant role in provoking drug-seeking behaviour evoked by exposure to contextual cues and, putatively, tobacco cravings in habitual smokers exposed to cues associated with their smoking habit.
Positive_regulation (stimulation) of mGluR5 associated with nicotine addiction
16) Confidence 0.45 Published 2010 Journal Psychopharmacology (Berl) Section Body Doc Link PMC2885299 Disease Relevance 0.33 Pain Relevance 0.41
Furthermore, there is a growing body of evidence that the role of glutamate in conditioned responding may depend to a significant degree upon the stimulation of mGluR5 receptors (Martin-Fardon et al. 2009; Bäckström and Hyytiä 2007).
Positive_regulation (stimulation) of mGluR5 in body associated with glutamate
17) Confidence 0.45 Published 2010 Journal Psychopharmacology (Berl) Section Body Doc Link PMC2885299 Disease Relevance 0.16 Pain Relevance 0.50
Metabotropic glutamate receptor 5 (mGlu5) negative allosteric modulators (NAMs) have previously been implicated in a number of pathophysiological conditions, based on preclinical, and to some extent clinical, proof of concept for migraine, gastroesophageal reflux disease, Parkinson's disease and anxiety.
Positive_regulation (Metabotropic) of glutamate receptor 5 associated with migraine, glutamate receptor, anxiety disorder, gastroesophageal reflux disease and disease
18) Confidence 0.44 Published 2010 Journal Expert Opin Ther Pat Section Abstract Doc Link 20180623 Disease Relevance 0.36 Pain Relevance 0.22
These results indicate that neuronal glutamate transporters limit mGluR5 activation and endocannabinoid signaling, but may be overwhelmed during conditions of elevated glutamate release.
Positive_regulation (activation) of mGluR5 in neuronal associated with endocannabinoid and glutamate
19) Confidence 0.42 Published 2008 Journal J. Neurosci. Section Abstract Doc Link 18216189 Disease Relevance 0.07 Pain Relevance 0.80
The level of mGluR5 protein was significantly up-regulated in TG 3 days after CFA-induced masseter inflammation.
Positive_regulation (up-regulated) of mGluR5 protein in masseter associated with inflammation
20) Confidence 0.41 Published 2007 Journal Neurosci. Lett. Section Abstract Doc Link 17560028 Disease Relevance 0.86 Pain Relevance 0.71

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox