INT78678

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Context Info
Confidence 0.70
First Reported 1998
Last Reported 2009
Negated 0
Speculated 2
Reported most in Abstract
Documents 12
Total Number 15
Disease Relevance 2.13
Pain Relevance 7.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Dbi) transport (Dbi) mitochondrion (Dbi)
extracellular space (Dbi) plasma membrane (Dbi) nucleus (Dbi)
Anatomy Link Frequency
neurons 3
brain 3
cerebral cortex 2
Dbi (Mus musculus)
Pain Link Frequency Relevance Heat
Morphine 60 99.98 Very High Very High Very High
narcan 14 99.30 Very High Very High Very High
antagonist 26 99.14 Very High Very High Very High
cerebral cortex 6 99.08 Very High Very High Very High
Nicotine 24 99.06 Very High Very High Very High
withdrawal 8 99.04 Very High Very High Very High
opioid receptor 9 98.90 Very High Very High Very High
alcohol 12 98.86 Very High Very High Very High
addiction 12 97.76 Very High Very High Very High
Neuropeptide 2 93.48 High High
Disease Link Frequency Relevance Heat
Substance Withdrawal Syndrome 2 99.36 Very High Very High Very High
Drug Dependence 12 97.76 Very High Very High Very High
Repression 4 96.08 Very High Very High Very High
Anxiety Disorder 3 93.12 High High
Opiate Addiction 6 83.04 Quite High
Stress 29 82.60 Quite High
Pain 1 82.32 Quite High
Metabolic Syndrome 46 78.28 Quite High
Insulin Resistance 50 61.44 Quite High
Diabetes Mellitus 36 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Continuous treatment with morphine increases diazepam binding inhibitor mRNA in mouse brain.
Positive_regulation (increases) of diazepam binding inhibitor in brain associated with narcan and morphine
1) Confidence 0.70 Published 1998 Journal J. Neurochem. Section Title Doc Link 9832166 Disease Relevance 0 Pain Relevance 0.83
A significant increase in DBI mRNA was observed after sustained exposure to 0.3 microM morphine for 2 days, and the maximal expression occurred after 2 days of exposure, whereas transient exposure to 0.3 microM morphine for 15 min, 1 hr, and 3 hr produced no changes in the expression.
Positive_regulation (increase) of DBI mRNA associated with morphine
2) Confidence 0.70 Published 2007 Journal J. Neurosci. Res. Section Abstract Doc Link 17638297 Disease Relevance 0 Pain Relevance 0.69
We investigated the mechanisms underlying the increase in diazepam binding inhibitor (DBI) and its mRNA expression induced by nicotine (0.1 microM) exposure for 24 h using mouse cerebral cortical neurons in primary culture.
Spec (investigated) Positive_regulation (increase) of DBI in neurons associated with nicotine
3) Confidence 0.67 Published 2000 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 11038246 Disease Relevance 0 Pain Relevance 0.47
We investigated the mechanisms underlying the increase in diazepam binding inhibitor (DBI) and its mRNA expression induced by nicotine (0.1 microM) exposure for 24 h using mouse cerebral cortical neurons in primary culture.
Spec (investigated) Positive_regulation (increase) of diazepam binding inhibitor in neurons associated with nicotine
4) Confidence 0.67 Published 2000 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 11038246 Disease Relevance 0 Pain Relevance 0.47
In addition, both a calmodulin antagonist and a CaM II kinase inhibitor significantly suppressed the morphine-induced increase in DBI mRNA.
Positive_regulation (increase) of DBI mRNA associated with antagonist and morphine
5) Confidence 0.61 Published 2007 Journal J. Neurosci. Res. Section Abstract Doc Link 17638297 Disease Relevance 0 Pain Relevance 0.97
On the other hand, kappa- and delta-opioid receptor antagonists showed no effects on the morphine-induced increase in DBI mRNA.
Positive_regulation (increase) of DBI mRNA associated with antagonist, opioid receptor and morphine
6) Confidence 0.61 Published 2007 Journal J. Neurosci. Res. Section Abstract Doc Link 17638297 Disease Relevance 0 Pain Relevance 1.05
This study sought to elucidate the precise mechanisms of DBI mRNA up-regulation by long-term treatment with morphine using primary cultures of mouse cerebral cortical neurons.
Positive_regulation (up-regulation) of DBI mRNA in neurons associated with morphine
7) Confidence 0.61 Published 2007 Journal J. Neurosci. Res. Section Abstract Doc Link 17638297 Disease Relevance 0 Pain Relevance 0.62
The levels of DBI protein and its mRNA significantly increased in the brain derived from mice dependent on alcohol (ethanol), nicotine and morphine, and abrupt cessation of these drugs facilitated further increase in DBI expression.
Positive_regulation (increased) of DBI protein in brain associated with nicotine, morphine and alcohol
8) Confidence 0.47 Published 2001 Journal Nippon Yakurigaku Zasshi Section Abstract Doc Link 11288485 Disease Relevance 0.74 Pain Relevance 0.83
When we examined brain from mice dependent on alcohol, nicotine, and morphine, we observed that the levels of DBI protein and its mRNA significantly increased.
Positive_regulation (increased) of DBI protein in brain associated with nicotine, morphine and alcohol
9) Confidence 0.47 Published 2004 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 15542765 Disease Relevance 0.77 Pain Relevance 0.76
Furthermore, this enhanced emotional stress-induced antinociception might be attributable to an increase in the production and/or release of endogenous ligands for benzodiazepine receptors, such as diazepam binding inhibitor, which act as inverse benzodiazepine receptor agonists.


Positive_regulation (increase) of diazepam binding inhibitor
10) Confidence 0.45 Published 2000 Journal Psychopharmacology (Berl.) Section Body Doc Link 10867967 Disease Relevance 0 Pain Relevance 0
Our previous in vivo experiment demonstrates that chronic morphine treatment up-regulates diazepam binding inhibitor (DBI) transcripts in mouse cerebral cortex, although detailed mechanisms were unclear (Katsura et al. [1998] J.
Positive_regulation (up-regulates) of diazepam binding inhibitor in cerebral cortex associated with cerebral cortex and morphine
11) Confidence 0.41 Published 2007 Journal J. Neurosci. Res. Section Abstract Doc Link 17638297 Disease Relevance 0 Pain Relevance 0.47
Our previous in vivo experiment demonstrates that chronic morphine treatment up-regulates diazepam binding inhibitor (DBI) transcripts in mouse cerebral cortex, although detailed mechanisms were unclear (Katsura et al. [1998] J.
Positive_regulation (up-regulates) of DBI in cerebral cortex associated with cerebral cortex and morphine
12) Confidence 0.41 Published 2007 Journal J. Neurosci. Res. Section Abstract Doc Link 17638297 Disease Relevance 0 Pain Relevance 0.47
ACBP, responsible for transporting acyl-CoA esters intracellularly, is downregulated during fasting but induced by insulin through SREBP-1c, and fibrates through PPAR?
Positive_regulation (induced) of ACBP
13) Confidence 0.36 Published 2009 Journal PPAR Research Section Body Doc Link PMC2840373 Disease Relevance 0.23 Pain Relevance 0
Thus ACBP is a dual PPAR?
Positive_regulation (dual) of ACBP
14) Confidence 0.36 Published 2009 Journal PPAR Research Section Body Doc Link PMC2840373 Disease Relevance 0.22 Pain Relevance 0
The gel filtration analyses revealed that a higher molecular weight form of ir beta-EP, putative POMC, was increased in CRH KO, but the beta-EP peak level was small and similar between two groups.
Positive_regulation (increased) of EP
15) Confidence 0.14 Published 2004 Journal Neurosci. Lett. Section Abstract Doc Link 15331153 Disease Relevance 0.16 Pain Relevance 0.08

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