INT78816

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Context Info
Confidence 0.68
First Reported 1998
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 9
Total Number 10
Disease Relevance 8.36
Pain Relevance 1.55

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (ICAM1) cell adhesion (ICAM1) plasma membrane (ICAM1)
Anatomy Link Frequency
endothelial cells 4
endothelium 4
skin 4
ICAM1 (Homo sapiens)
Pain Link Frequency Relevance Heat
qutenza 3 99.98 Very High Very High Very High
substance P 14 99.50 Very High Very High Very High
Neuropeptide 7 99.46 Very High Very High Very High
Inflammation 158 96.80 Very High Very High Very High
Inflammatory response 28 95.96 Very High Very High Very High
Pain 1 95.64 Very High Very High Very High
cINOD 1 60.32 Quite High
cytokine 18 37.04 Quite Low
chemokine 14 35.92 Quite Low
dexamethasone 4 26.20 Quite Low
Disease Link Frequency Relevance Heat
Adhesions 387 100.00 Very High Very High Very High
Nicotine Addiction 780 99.98 Very High Very High Very High
Pulmonary Disease 99 99.84 Very High Very High Very High
Pneumonia 1 96.80 Very High Very High Very High
INFLAMMATION 194 96.76 Very High Very High Very High
Pain 1 95.64 Very High Very High Very High
Disease 118 95.24 Very High Very High Very High
Peripheral Arterial Disease 7 94.40 High High
Stress 18 85.72 High High
Periodontal Disease 44 81.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Smoking directly causes an increase in soluble ICAM-1 and specific CD44 variant concentrations in the systemic circulation, diluting several previous diagnostic and prognostic attributions.
Positive_regulation (causes) of Positive_regulation (increase) of ICAM-1 associated with nicotine addiction
1) Confidence 0.68 Published 2003 Journal Tob Induc Dis Section Body Doc Link PMC2671531 Disease Relevance 1.39 Pain Relevance 0
Smoking directly causes an increase in soluble ICAM-1 and specific CD44 variant concentrations in the systemic circulation, diluting several previous diagnostic and prognostic attributions.
Positive_regulation (causes) of Positive_regulation (increase) of ICAM-1 associated with nicotine addiction
2) Confidence 0.68 Published 2003 Journal Tob Induc Dis Section Body Doc Link PMC2669563 Disease Relevance 1.39 Pain Relevance 0
In conclusion, trypsinated serum induces the upregulation of both membrane-bound ICAM-1 on endothelial cells and soluble ICAM-1.
Positive_regulation (induces) of Positive_regulation (upregulation) of ICAM-1 in endothelial cells
3) Confidence 0.67 Published 2004 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 15308472 Disease Relevance 0.19 Pain Relevance 0
In conclusion, trypsinated serum induces the upregulation of both membrane-bound ICAM-1 on endothelial cells and soluble ICAM-1.
Positive_regulation (induces) of Positive_regulation (upregulation) of ICAM-1 in endothelial cells
4) Confidence 0.49 Published 2004 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 15308472 Disease Relevance 0.19 Pain Relevance 0
Our results indicate that the topical cutaneous application of the neuropeptide-releasing agent capsaicin resulted in increased ICAM-1 and VCAM-1 immunostaining of microvascular cells in the skin of human volunteers.
Positive_regulation (resulted) of Positive_regulation (increased) of ICAM-1 in skin associated with qutenza and neuropeptide
5) Confidence 0.47 Published 2000 Journal J. Investig. Dermatol. Symp. Proc. Section Abstract Doc Link 11147679 Disease Relevance 0.45 Pain Relevance 0.66
These results indicate that neuropeptides such as SP are capable of directly activating HDMEC to express increased levels of functional ICAM-1 and further support the role of the cutaneous neurological system in modulating inflammatory processes in the skin.
Positive_regulation (activating) of Positive_regulation (increased) of ICAM-1 in skin associated with inflammation, neuropeptide and substance p
6) Confidence 0.46 Published 1998 Journal Am. J. Physiol. Section Abstract Doc Link 9843720 Disease Relevance 0.22 Pain Relevance 0.51
Equally, there is a pressing need to understand the mechanisms by which components, or metabolites, of tobacco smoke induce the upregulation and shedding of sICAM-1 molecules from the endothelium, and other cellular sources.
Positive_regulation (induce) of Positive_regulation (upregulation) of sICAM-1 in endothelium associated with nicotine addiction
7) Confidence 0.40 Published 2003 Journal Tob Induc Dis Section Body Doc Link PMC2669563 Disease Relevance 0.98 Pain Relevance 0
Equally, there is a pressing need to understand the mechanisms by which components, or metabolites, of tobacco smoke induce the upregulation and shedding of sICAM-1 molecules from the endothelium, and other cellular sources.
Positive_regulation (induce) of Positive_regulation (upregulation) of sICAM-1 in endothelium associated with nicotine addiction
8) Confidence 0.40 Published 2003 Journal Tob Induc Dis Section Body Doc Link PMC2671531 Disease Relevance 0.98 Pain Relevance 0
Serum levels of E-selectin, P-selectin, L-selectin, intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-I (VCAM-1) were measured at rest and after the performance of a treadmill walking test (treadmill speed 3.5 km h(-1), inclination 12%) in the untreated condition, and again after treatment with LPC.
Positive_regulation (measured) of Positive_regulation (levels) of adhesion molecule-1 associated with adhesions
9) Confidence 0.02 Published 2001 Journal Pharmacol. Res. Section Abstract Doc Link 11592865 Disease Relevance 0.86 Pain Relevance 0.10
Increased levels of circulating intercellular adhesion molecule-1 (cICAM-1) and circulating E-selectin (c-E-selectin) in serum, and of cICAM-1 in BAL, were observed in COPD patients relative to controls.
Positive_regulation (observed) of Positive_regulation (Increased) of cICAM-1 associated with pulmonary disease and adhesions
10) Confidence 0.01 Published 2008 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2629979 Disease Relevance 1.72 Pain Relevance 0.28

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