INT789

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Context Info
Confidence 0.67
First Reported 1978
Last Reported 2010
Negated 3
Speculated 1
Reported most in Abstract
Documents 69
Total Number 72
Disease Relevance 14.07
Pain Relevance 47.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (YY1) chromosome organization (YY1) RNA binding (YY1)
plasma membrane (YY1) nucleus (YY1) intracellular (YY1)
Anatomy Link Frequency
nociceptor 4
spinal 2
SH-SY5Y 1
tail 1
brain 1
YY1 (Homo sapiens)
Pain Link Frequency Relevance Heat
opioid receptor 92 100.00 Very High Very High Very High
Pain 66 100.00 Very High Very High Very High
Enkephalin 62 100.00 Very High Very High Very High
Opioid 50 100.00 Very High Very High Very High
Delta opioid receptors 48 100.00 Very High Very High Very High
opiate 45 100.00 Very High Very High Very High
Cholecystokinin 35 100.00 Very High Very High Very High
nociceptor 33 100.00 Very High Very High Very High
Analgesic 26 100.00 Very High Very High Very High
Adelta 24 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 93 100.00 Very High Very High Very High
Injury 7 99.92 Very High Very High Very High
Porphyria 5 99.92 Very High Very High Very High
Ganglion Cysts 7 99.62 Very High Very High Very High
Hypoxia 32 99.60 Very High Very High Very High
Neuroblastoma 9 99.16 Very High Very High Very High
Disease 38 99.10 Very High Very High Very High
Hereditary Coproporphyria 1 98.96 Very High Very High Very High
Pain 85 98.56 Very High Very High Very High
Anxiety Disorder 7 98.12 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Together, these results suggest a functional significance for antagonist-induced mu and delta opiate receptor up-regulation.
Positive_regulation (up-regulation) of delta associated with antagonist and opiate
1) Confidence 0.67 Published 1985 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 2982011 Disease Relevance 0 Pain Relevance 0.81
It is suggested that this orthogonal orientation serves as an "address" to facilitate activation of delta receptors.
Positive_regulation (activation) of delta
2) Confidence 0.67 Published 1997 Journal J. Med. Chem. Section Abstract Doc Link 9301669 Disease Relevance 0 Pain Relevance 0.60
These data indicate that activation of delta-opioid receptors can reduce naloxone-induced LH release, suggesting a possible role of delta receptors in opioidergic modulation of LH secretion in women.
Positive_regulation (activation) of delta associated with narcan and delta opioid receptors
3) Confidence 0.67 Published 1998 Journal Hum. Reprod. Section Abstract Doc Link 9647539 Disease Relevance 0 Pain Relevance 0.57
Hence, low-frequency and high-frequency TENS produces antihyperalgesia by activation of mu- and delta-opioid receptors, respectively, in the RVM.
Positive_regulation (activation) of delta in RVM associated with medulla, delta opioid receptors and transcutaneous nerve stimulation
4) Confidence 0.67 Published 2001 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 11408550 Disease Relevance 0.11 Pain Relevance 1.50
Activation of delta- and kappa-opioid receptors had no effect on endogenous norepinephrine release.
Positive_regulation (Activation) of delta associated with kappa opioid receptor
5) Confidence 0.67 Published 1997 Journal Brain Res. Bull. Section Abstract Doc Link 9288827 Disease Relevance 0 Pain Relevance 0.54
In ND8-47 cells, a neuroblastoma x dorsal root ganglion hybrid cell line, activation of delta-opioid receptors induced an increase in the intracellular free calcium concentration ([Ca2+]i) through dihydropyridine-sensitive calcium channels.
Positive_regulation (activation) of delta in dorsal root ganglion associated with ganglion cysts, dorsal root ganglion, neuroblastoma, calcium channel and delta opioid receptors
6) Confidence 0.67 Published 1995 Journal Mol. Pharmacol. Section Abstract Doc Link 7651350 Disease Relevance 0.43 Pain Relevance 0.26
The summarized results provide important cellular substrates for N-methyl-D-aspartate (NMDA)-mediated glutamatergic transmission and activation of either serotoninergic (5-HT2A), adrenergic (alpha 2A), or mu- or delta opioid receptors within the baroreceptor reflex circuit.
Positive_regulation (activation) of delta associated with delta opioid receptors
7) Confidence 0.67 Published 2003 Journal Cell. Mol. Neurobiol. Section Abstract Doc Link 14514029 Disease Relevance 0 Pain Relevance 0.32
This result indicates that a functional supersensitivity occurs as a result of the selective up-regulation of mu and delta receptors.
Positive_regulation (up-regulation) of delta
8) Confidence 0.67 Published 1985 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 2982011 Disease Relevance 0 Pain Relevance 0.91
We hypothesized that an activation of mu and delta receptors and/or inactivation of kappa receptors on striatal spiny cells might alleviate parkinsonian symptoms and recover locomotor activity.
Positive_regulation (activation) of delta associated with parkinson's disease and eae
9) Confidence 0.67 Published 2003 Journal Usp Fiziol Nauk Section Abstract Doc Link 14658303 Disease Relevance 0.10 Pain Relevance 0.48
Delta opiate receptors are increased in the caudate and mu binding is reduced in the striatum.
Positive_regulation (increased) of Delta in striatum associated with opiate
10) Confidence 0.67 Published 1987 Journal Can J Neurol Sci Section Abstract Doc Link 2824009 Disease Relevance 0.39 Pain Relevance 1.43
In addition, isoflurane directly activated alpha(4)beta(2)delta GABA(A)-Rs expressed in human embryonic kidney 293 cells, and it was more potent at alpha(4)beta(2)delta than at alpha(1)beta(2)gamma(2) receptors (the presumptive extrasynaptic and synaptic GABA(A)-R subtypes in VB neurons).
Positive_regulation (activated) of delta in embryonic kidney associated with gaba and isoflurane
11) Confidence 0.67 Published 2008 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 18094320 Disease Relevance 0.44 Pain Relevance 1.00
Activation of cloned delta-opioid receptors stably expressed in GH(3) cells inhibits both spontaneous Ca(2+) signaling and basal prolactin release.
Positive_regulation (Activation) of delta associated with delta opioid receptors
12) Confidence 0.49 Published 2000 Journal J. Neurophysiol. Section Abstract Doc Link 10805669 Disease Relevance 0 Pain Relevance 0.32
Opioid receptor agonists produce analgesia through multiple systems activated by stimulation of mu(1), mu(2), delta(1), delta(2) and kappa(1) opioid receptors.
Positive_regulation (stimulation) of delta associated with agonist, opioid receptor and analgesia
13) Confidence 0.49 Published 2000 Journal Eur. J. Pharmacol. Section Abstract Doc Link 10688982 Disease Relevance 0 Pain Relevance 1.10
Mu- and delta-opioid receptors have been found to be increased in temporal neocortex overlying mesial temporal epileptic foci, but with different patterns of increase.
Positive_regulation (increased) of delta in neocortex associated with epilepsy and delta opioid receptors
14) Confidence 0.49 Published 1999 Journal Rev. Neurol. (Paris) Section Abstract Doc Link 10472664 Disease Relevance 0.90 Pain Relevance 0.32
In N18TG2 neuroblastoma cells, the opioid agonist etorphine and the cannabinoid agonist CP-55940 induced the phosphorylation of ERK by a similar mechanism that involved activation of delta-opioid receptors or CB1 cannabinoid receptors coupled to Gi/Go proteins, matrix metalloproteases, vascular endothelial growth factor (VEGF) receptors and MAPK/ERK kinase (MEK).
Positive_regulation (activation) of delta in N18TG2 associated with neuroblastoma, mu agonist, cannabinoid receptor, cannabinoid, agonist, delta opioid receptors and immobilon
15) Confidence 0.49 Published 2008 Journal Brain Res. Section Abstract Doc Link 18068691 Disease Relevance 0.10 Pain Relevance 0.73
In area CA1 of the hippocampus, the activation of mu- and delta-opioid receptors inhibits these interneurons, thereby increasing the excitability of the pyramidal cells.
Positive_regulation (activation) of delta in pyramidal cells associated with pyramidal cell, delta opioid receptors and hippocampus
16) Confidence 0.49 Published 1999 Journal J. Neurosci. Section Abstract Doc Link 9870941 Disease Relevance 0 Pain Relevance 0.44
Furthermore, activation of mu opioid receptors in the ventral tegmental area, or of mu and delta opioid receptors in the nucleus accumbens enhances the extracellular concentration of dopamine in the nucleus accumbens.
Positive_regulation (activation) of delta in ventral associated with nucleus accumbens, ventral tegmentum, dopamine, mu opioid receptor and delta opioid receptors
17) Confidence 0.49 Published 2009 Journal Curr Top Med Chem Section Abstract Doc Link 19747123 Disease Relevance 0.06 Pain Relevance 1.52
Unlike the p-haloPhe4 analogues of DPDPE and the deltorphins, similar analogues of DPADPE with electron-withdrawing groups substituted at the para-position of the Phe4 aromatic ring did not all have increased potency and selectivity for delta opioid receptors, but all retained high potency and selectivity for delta opioid receptors greater than DPDPE.
Neg (not) Positive_regulation (increased) of delta associated with delta opioid receptors and potency
18) Confidence 0.49 Published 1997 Journal J. Pept. Res. Section Abstract Doc Link 9309580 Disease Relevance 0 Pain Relevance 0.28
Amoxapine also activated delta-opioid receptors in rat dorsal striatum and nucleus accumbens and human frontal cortex.
Positive_regulation (activated) of delta in dorsal associated with nucleus accumbens, urological neuroanatomy and delta opioid receptors
19) Confidence 0.49 Published 2010 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 19828880 Disease Relevance 0.16 Pain Relevance 1.01
Low (4 Hz) and high (100 Hz) frequency TENS activate mu- and delta-opioid receptors, respectively, It is thus possible that TENS would be less effective in morphine-tolerant subjects.
Positive_regulation (activate) of delta associated with delta opioid receptors, transcutaneous nerve stimulation and morphine
20) Confidence 0.49 Published 2000 Journal Eur J Pain Section Abstract Doc Link 10957699 Disease Relevance 0.53 Pain Relevance 1.85

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